Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191569797> ?p ?o ?g. }
- W3191569797 endingPage "4126" @default.
- W3191569797 startingPage "4112" @default.
- W3191569797 abstract "Abstract Evi1 is a transcription factor essential for the development as well as progression of acute myeloid leukemia (AML) and high Evi1 AML is associated with extremely poor clinical outcome. Since targeting metabolic vulnerability is the emerging therapeutic strategy of cancer, we herein investigated a novel therapeutic target of Evi1 by analyzing transcriptomic, epigenetic, and metabolomic profiling of mouse high Evi1 leukemia cells. We revealed that Evi1 overexpression and Evi1‐driven leukemic transformation upregulate transcription of gluconeogenesis enzyme Fbp1 and other pentose phosphate enzymes with interaction between Evi1 and the enhancer region of these genes. Metabolome analysis using Evi1‐overexpressing leukemia cells uncovered pentose phosphate pathway upregulation by Evi1 overexpression. Suppression of Fbp1 as well as pentose phosphate pathway enzymes by shRNA‐mediated knockdown selectively decreased Evi1‐driven leukemogenesis in vitro. Moreover, pharmacological or shRNA‐mediated Fbp1 inhibition in secondarily transplanted Evi1‐overexpressing leukemia mouse significantly decreased leukemia cell burden. Collectively, targeting FBP1 is a promising therapeutic strategy of high Evi1 AML." @default.
- W3191569797 created "2021-08-16" @default.
- W3191569797 creator A5033542791 @default.
- W3191569797 creator A5066000610 @default.
- W3191569797 creator A5073327812 @default.
- W3191569797 creator A5085709435 @default.
- W3191569797 creator A5090849761 @default.
- W3191569797 date "2021-08-22" @default.
- W3191569797 modified "2023-10-17" @default.
- W3191569797 title "Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation" @default.
- W3191569797 cites W1481643702 @default.
- W3191569797 cites W1977129385 @default.
- W3191569797 cites W1978537489 @default.
- W3191569797 cites W1978902427 @default.
- W3191569797 cites W1991309446 @default.
- W3191569797 cites W2003336545 @default.
- W3191569797 cites W2004232360 @default.
- W3191569797 cites W2014677321 @default.
- W3191569797 cites W2017337160 @default.
- W3191569797 cites W2017746705 @default.
- W3191569797 cites W2018507034 @default.
- W3191569797 cites W2021341670 @default.
- W3191569797 cites W2039081870 @default.
- W3191569797 cites W2041418254 @default.
- W3191569797 cites W2057139407 @default.
- W3191569797 cites W2065552179 @default.
- W3191569797 cites W2067284696 @default.
- W3191569797 cites W2069663698 @default.
- W3191569797 cites W2074320863 @default.
- W3191569797 cites W2074426771 @default.
- W3191569797 cites W2077330278 @default.
- W3191569797 cites W2080678293 @default.
- W3191569797 cites W2081463586 @default.
- W3191569797 cites W2100883771 @default.
- W3191569797 cites W2105232554 @default.
- W3191569797 cites W2106194243 @default.
- W3191569797 cites W2110487370 @default.
- W3191569797 cites W2111163869 @default.
- W3191569797 cites W2125597344 @default.
- W3191569797 cites W2126663937 @default.
- W3191569797 cites W2154313451 @default.
- W3191569797 cites W2163179316 @default.
- W3191569797 cites W2170551349 @default.
- W3191569797 cites W2171808845 @default.
- W3191569797 cites W2322763157 @default.
- W3191569797 cites W2419140434 @default.
- W3191569797 cites W2557073162 @default.
- W3191569797 cites W2588498659 @default.
- W3191569797 cites W2592973432 @default.
- W3191569797 cites W2605757478 @default.
- W3191569797 cites W2640919312 @default.
- W3191569797 cites W2735063286 @default.
- W3191569797 cites W2746855242 @default.
- W3191569797 cites W2768765259 @default.
- W3191569797 cites W2772417176 @default.
- W3191569797 cites W2783667496 @default.
- W3191569797 cites W2786875007 @default.
- W3191569797 cites W2787422770 @default.
- W3191569797 cites W2789784588 @default.
- W3191569797 cites W2802555809 @default.
- W3191569797 cites W2809203760 @default.
- W3191569797 cites W2888829515 @default.
- W3191569797 cites W2896480326 @default.
- W3191569797 cites W2897184255 @default.
- W3191569797 cites W2900310474 @default.
- W3191569797 cites W2900616886 @default.
- W3191569797 cites W2979422509 @default.
- W3191569797 cites W2981560800 @default.
- W3191569797 cites W3045910546 @default.
- W3191569797 cites W4231346141 @default.
- W3191569797 doi "https://doi.org/10.1111/cas.15098" @default.
- W3191569797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8486204" @default.
- W3191569797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34363719" @default.
- W3191569797 hasPublicationYear "2021" @default.
- W3191569797 type Work @default.
- W3191569797 sameAs 3191569797 @default.
- W3191569797 citedByCount "3" @default.
- W3191569797 countsByYear W31915697972022 @default.
- W3191569797 countsByYear W31915697972023 @default.
- W3191569797 crossrefType "journal-article" @default.
- W3191569797 hasAuthorship W3191569797A5033542791 @default.
- W3191569797 hasAuthorship W3191569797A5066000610 @default.
- W3191569797 hasAuthorship W3191569797A5073327812 @default.
- W3191569797 hasAuthorship W3191569797A5085709435 @default.
- W3191569797 hasAuthorship W3191569797A5090849761 @default.
- W3191569797 hasBestOaLocation W31915697971 @default.
- W3191569797 hasConcept C104317684 @default.
- W3191569797 hasConcept C127561419 @default.
- W3191569797 hasConcept C173396325 @default.
- W3191569797 hasConcept C181199279 @default.
- W3191569797 hasConcept C190232843 @default.
- W3191569797 hasConcept C190283241 @default.
- W3191569797 hasConcept C20251656 @default.
- W3191569797 hasConcept C203014093 @default.
- W3191569797 hasConcept C2778461978 @default.
- W3191569797 hasConcept C2778729363 @default.
- W3191569797 hasConcept C2781021840 @default.
- W3191569797 hasConcept C2910954276 @default.