Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191570032> ?p ?o ?g. }
- W3191570032 endingPage "364" @default.
- W3191570032 startingPage "353" @default.
- W3191570032 abstract "Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO2-FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein's expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO2-FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO2-FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury." @default.
- W3191570032 created "2021-08-16" @default.
- W3191570032 creator A5021760409 @default.
- W3191570032 creator A5080481324 @default.
- W3191570032 date "2021-07-01" @default.
- W3191570032 modified "2023-10-17" @default.
- W3191570032 title "Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation" @default.
- W3191570032 cites W1506442914 @default.
- W3191570032 cites W1508323668 @default.
- W3191570032 cites W1586722842 @default.
- W3191570032 cites W1592393293 @default.
- W3191570032 cites W1633340712 @default.
- W3191570032 cites W1639924204 @default.
- W3191570032 cites W1643210644 @default.
- W3191570032 cites W1743854985 @default.
- W3191570032 cites W1878686232 @default.
- W3191570032 cites W1909650275 @default.
- W3191570032 cites W1926255205 @default.
- W3191570032 cites W1967677439 @default.
- W3191570032 cites W1968178474 @default.
- W3191570032 cites W1984981225 @default.
- W3191570032 cites W1988780457 @default.
- W3191570032 cites W1991594689 @default.
- W3191570032 cites W1993635466 @default.
- W3191570032 cites W1995468150 @default.
- W3191570032 cites W1995593745 @default.
- W3191570032 cites W1998457189 @default.
- W3191570032 cites W2002658398 @default.
- W3191570032 cites W2005674716 @default.
- W3191570032 cites W2006902800 @default.
- W3191570032 cites W2008479676 @default.
- W3191570032 cites W2008906556 @default.
- W3191570032 cites W2010571219 @default.
- W3191570032 cites W2011397271 @default.
- W3191570032 cites W2016750615 @default.
- W3191570032 cites W2017556004 @default.
- W3191570032 cites W2018764844 @default.
- W3191570032 cites W2019221616 @default.
- W3191570032 cites W2022716776 @default.
- W3191570032 cites W2031801552 @default.
- W3191570032 cites W2036285327 @default.
- W3191570032 cites W2037894162 @default.
- W3191570032 cites W2047852384 @default.
- W3191570032 cites W2049311375 @default.
- W3191570032 cites W2049659786 @default.
- W3191570032 cites W2051690606 @default.
- W3191570032 cites W2052233887 @default.
- W3191570032 cites W2055063197 @default.
- W3191570032 cites W2058502722 @default.
- W3191570032 cites W2060004514 @default.
- W3191570032 cites W2061714395 @default.
- W3191570032 cites W2064636293 @default.
- W3191570032 cites W2068854215 @default.
- W3191570032 cites W2073543023 @default.
- W3191570032 cites W2080156305 @default.
- W3191570032 cites W2083147016 @default.
- W3191570032 cites W2084837014 @default.
- W3191570032 cites W2085933778 @default.
- W3191570032 cites W2086816976 @default.
- W3191570032 cites W2088250547 @default.
- W3191570032 cites W2092637470 @default.
- W3191570032 cites W2092842004 @default.
- W3191570032 cites W2094356159 @default.
- W3191570032 cites W2097750604 @default.
- W3191570032 cites W2106877484 @default.
- W3191570032 cites W2109621677 @default.
- W3191570032 cites W2113743444 @default.
- W3191570032 cites W2115338196 @default.
- W3191570032 cites W2116926077 @default.
- W3191570032 cites W2119856479 @default.
- W3191570032 cites W2119860509 @default.
- W3191570032 cites W2120807382 @default.
- W3191570032 cites W2123950558 @default.
- W3191570032 cites W2123981503 @default.
- W3191570032 cites W2124568143 @default.
- W3191570032 cites W2126440278 @default.
- W3191570032 cites W2129205142 @default.
- W3191570032 cites W2130029858 @default.
- W3191570032 cites W2135919238 @default.
- W3191570032 cites W2138058962 @default.
- W3191570032 cites W2139181115 @default.
- W3191570032 cites W2140885918 @default.
- W3191570032 cites W2141314779 @default.
- W3191570032 cites W2143354656 @default.
- W3191570032 cites W2147596285 @default.
- W3191570032 cites W2148396744 @default.
- W3191570032 cites W2151417525 @default.
- W3191570032 cites W2151614363 @default.
- W3191570032 cites W2152081985 @default.
- W3191570032 cites W2154933226 @default.
- W3191570032 cites W2159979956 @default.
- W3191570032 cites W2161481261 @default.
- W3191570032 cites W2161982997 @default.
- W3191570032 cites W2164476520 @default.
- W3191570032 cites W2165643859 @default.
- W3191570032 cites W2170960160 @default.
- W3191570032 cites W2202703189 @default.
- W3191570032 cites W2234060878 @default.