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• W3191647181 endingPage "22042" @default.
• W3191647181 startingPage "22035" @default.
• W3191647181 abstract "Sulfonyl fluorides have widespread applications in many important fields, including ligation chemistry, chemical biology, and drug discovery. Therefore, new methods to increase the synthetic efficiency and expand the available structures of sulfonyl fluorides are highly in demand. Here, we introduce a new and powerful class of sulfonyl fluoride hubs, β-chloro alkenylsulfonyl fluorides (BCASF), which can be constructed via radical chloro-fluorosulfonyl difunctionalization of alkynes under photoredox conditions. BCASF molecules exhibit versatile reactivities and well undergo a series of transformations at the chloride site while keeping the sulfonyl fluoride group intact, including reduction, Suzuki coupling, Sonogashira coupling, as well as nucleophilic substitution with various nitrogen, oxygen, and sulfur nucleophiles. By using BCASF as a synthetic hub, a wide range of sulfonyl fluorides becomes readily accessible, such as cis alkenylsulfonyl fluorides, dienylsulfonyl fluorides, and ynenylsulfonyl fluorides, which are challenging or even not possible to synthesize before with the known methods. Moreover, further application of BCASF to the late-stage modification of peptides and drugs is also demonstrated." @default.
• W3191647181 created "2021-08-16" @default.
• W3191647181 creator A5019400913 @default.
• W3191647181 creator A5061078231 @default.
• W3191647181 creator A5061117495 @default.
• W3191647181 creator A5063584514 @default.
• W3191647181 creator A5087827312 @default.
• W3191647181 creator A5014343645 @default.
• W3191647181 date "2021-08-25" @default.
• W3191647181 modified "2023-09-26" @default.
• W3191647181 title "Introducing A New Class of Sulfonyl Fluoride Hubs via Radical Chloro‐Fluorosulfonylation of Alkynes" @default.
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