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- W3191700846 abstract "Abstract Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients suffering from respiratory or cardiac failure. The ECMO-associated morbidity and mortality depends to a large extent on the underlying disease and is often related to systemic inflammation, consecutive immune paralysis and sepsis. Here we tested the hypothesis that human α1-antitrypsin (SERPINA1) due to its anti-protease and anti-inflammatory functions may attenuate ECMO-induced inflammation. We specifically aimed to test whether intravenous treatment with α1-antitrypsin reduces the release of cytokines in response to 2 h of experimental ECMO. Adult rats were intravenously infused with α1-antitrypsin immediately before starting veno-arterial ECMO. We measured selected pro- and anti-inflammatory cytokines and found, that systemic levels of tumor necrosis factor-α, interleukin-6 and interleukin-10 increase during experimental ECMO. As tachycardia and hypertension developed in response to α1-antitrypsin, a single additional bolus of fentanyl and midazolam was given. Treatment with α1-antitrypsin and higher sedative doses reduced all cytokine levels investigated. We suggest that α1-antitrypsin might have the potential to protect against both ECMO-induced systemic inflammation and immune paralysis. More studies are needed to corroborate our findings, to clarify the mechanisms by which α1-antitrypsin inhibits cytokine release in vivo and to explore the potential application of α1-antitrypsin in clinical ECMO." @default.
- W3191700846 created "2021-08-16" @default.
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- W3191700846 date "2021-08-04" @default.
- W3191700846 modified "2023-09-25" @default.
- W3191700846 title "Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation" @default.
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- W3191700846 doi "https://doi.org/10.1038/s41598-021-95119-y" @default.
- W3191700846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8339069" @default.
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- W3191700846 hasPublicationYear "2021" @default.
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