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- W3191786918 abstract "ABSTRACT Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes establish this pattern by selecting a cohort of axons for myelination; however, the distribution of myelin on distinct neurons and extent of internode replacement after demyelination remain to be defined. Here we show that myelination patterns of seven distinct neuron subtypes in somatosensory cortex are influenced by both axon diameter and neuronal identity. Preference for myelination of parvalbumin interneurons was preserved between cortical areas with varying myelin density, suggesting that regional differences in myelin abundance arises through local control of oligodendrogenesis. By imaging loss and regeneration of myelin sheaths in vivo we show that myelin distribution on individual axons was altered but overall myelin content on distinct neuron subtypes was restored. Our findings suggest that local changes in myelination are tolerated, allowing regenerated oligodendrocytes to restore myelin content on distinct neurons through opportunistic selection of axons." @default.
- W3191786918 created "2021-08-16" @default.
- W3191786918 creator A5045821378 @default.
- W3191786918 creator A5046088530 @default.
- W3191786918 date "2021-08-06" @default.
- W3191786918 modified "2023-10-16" @default.
- W3191786918 title "Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination" @default.
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- W3191786918 doi "https://doi.org/10.1038/s41467-021-25035-2" @default.
- W3191786918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8346564" @default.
- W3191786918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34362912" @default.
- W3191786918 hasPublicationYear "2021" @default.
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