FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191822012> ?p ?o ?g. }

• W3191822012 endingPage "3088" @default.
• W3191822012 startingPage "3078" @default.
• W3191822012 abstract "Abstract Interictal epileptiform discharges (IEDs) are a widely used biomarker in patients with epilepsy but lack specificity. It has been proposed that there are truly epileptogenic and less pathological or even protective IEDs. Recent studies suggest that highly pathological IEDs are characterized by high-frequency oscillations (HFOs). Here, we aimed to dissect these ‘HFO-IEDs’ at the single-neuron level, hypothesizing that the underlying mechanisms are distinct from ‘non-HFO-IEDs’. Analysing hybrid depth electrode recordings from patients with temporal lobe epilepsy, we found that single-unit firing rates were higher in HFO- than in non-HFO-IEDs. HFO-IEDs were characterized by a pronounced pre-peak increase in firing, which coincided with the preferential occurrence of HFOs, whereas in non-HFO-IEDs, there was only a mild pre-peak increase followed by a post-peak suppression. Comparing each unit’s firing during HFO-IEDs to its baseline activity, we found many neurons with a significant increase during the HFO component or ascending part, but almost none with a decrease. No such imbalance was observed during non-HFO-IEDs. Finally, comparing each unit’s firing directly between HFO- and non-HFO-IEDs, we found that most cells had higher rates during HFO-IEDs and, moreover, identified a distinct subset of neurons with a significant preference for this IED subtype. In summary, our study reveals that HFO- and non-HFO-IEDs have different single-unit correlates. In HFO-IEDs, many neurons are moderately activated, and some participate selectively, suggesting that both types of increased firing contribute to highly pathological IEDs." @default.
• W3191822012 created "2021-08-16" @default.
• W3191822012 creator A5001848078 @default.
• W3191822012 creator A5017999042 @default.
• W3191822012 creator A5024264979 @default.
• W3191822012 creator A5050713137 @default.
• W3191822012 creator A5061305446 @default.
• W3191822012 creator A5077327102 @default.
• W3191822012 creator A5083765806 @default.
• W3191822012 creator A5085253413 @default.
• W3191822012 creator A5086796260 @default.
• W3191822012 date "2021-08-03" @default.
• W3191822012 modified "2023-10-14" @default.
• W3191822012 title "Interictal spikes with and without high-frequency oscillation have different single-neuron correlates" @default.
• W3191822012 cites W1519218320 @default.
• W3191822012 cites W1955575446 @default.
• W3191822012 cites W1964145653 @default.
• W3191822012 cites W1967695195 @default.
• W3191822012 cites W1970931021 @default.
• W3191822012 cites W1976799656 @default.
• W3191822012 cites W1986138125 @default.
• W3191822012 cites W1987336136 @default.
• W3191822012 cites W1990187402 @default.
• W3191822012 cites W1990627393 @default.
• W3191822012 cites W1996378566 @default.
• W3191822012 cites W1997629662 @default.
• W3191822012 cites W2006815061 @default.
• W3191822012 cites W2008027377 @default.
• W3191822012 cites W2012896667 @default.
• W3191822012 cites W2020272049 @default.
• W3191822012 cites W2026153752 @default.
• W3191822012 cites W2027045997 @default.
• W3191822012 cites W2037481045 @default.
• W3191822012 cites W2038887856 @default.
• W3191822012 cites W2050215995 @default.
• W3191822012 cites W2050990654 @default.
• W3191822012 cites W2052104833 @default.
• W3191822012 cites W2052806196 @default.
• W3191822012 cites W2055249567 @default.
• W3191822012 cites W2056189505 @default.
• W3191822012 cites W2062292540 @default.
• W3191822012 cites W2063251658 @default.
• W3191822012 cites W2074069661 @default.
• W3191822012 cites W2083547018 @default.
• W3191822012 cites W2090415723 @default.
• W3191822012 cites W2115107366 @default.
• W3191822012 cites W2117133446 @default.
• W3191822012 cites W2122300627 @default.
• W3191822012 cites W2122755930 @default.
• W3191822012 cites W2126693856 @default.
• W3191822012 cites W2135266824 @default.
• W3191822012 cites W2141554976 @default.
• W3191822012 cites W2146282734 @default.
• W3191822012 cites W2152991135 @default.
• W3191822012 cites W2161367071 @default.
• W3191822012 cites W2166073443 @default.
• W3191822012 cites W2166543843 @default.
• W3191822012 cites W2218418953 @default.
• W3191822012 cites W2288238997 @default.
• W3191822012 cites W2321531002 @default.
• W3191822012 cites W2344566456 @default.
• W3191822012 cites W2349488931 @default.
• W3191822012 cites W2409571996 @default.
• W3191822012 cites W2606956957 @default.
• W3191822012 cites W2727532106 @default.
• W3191822012 cites W2788998765 @default.
• W3191822012 cites W2875003334 @default.
• W3191822012 cites W2885247192 @default.
• W3191822012 cites W2891111388 @default.
• W3191822012 cites W2923791042 @default.
• W3191822012 cites W2943251004 @default.
• W3191822012 cites W2946209108 @default.
• W3191822012 cites W2973520873 @default.
• W3191822012 cites W2989945266 @default.
• W3191822012 cites W3009744230 @default.
• W3191822012 cites W771024754 @default.
• W3191822012 doi "https://doi.org/10.1093/brain/awab288" @default.
• W3191822012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8634126" @default.
• W3191822012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34343264" @default.
• W3191822012 hasPublicationYear "2021" @default.
• W3191822012 type Work @default.
• W3191822012 sameAs 3191822012 @default.
• W3191822012 citedByCount "25" @default.
• W3191822012 countsByYear W31918220122021 @default.
• W3191822012 countsByYear W31918220122022 @default.
• W3191822012 countsByYear W31918220122023 @default.
• W3191822012 crossrefType "journal-article" @default.
• W3191822012 hasAuthorship W3191822012A5001848078 @default.
• W3191822012 hasAuthorship W3191822012A5017999042 @default.
• W3191822012 hasAuthorship W3191822012A5024264979 @default.
• W3191822012 hasAuthorship W3191822012A5050713137 @default.
• W3191822012 hasAuthorship W3191822012A5061305446 @default.
• W3191822012 hasAuthorship W3191822012A5077327102 @default.
• W3191822012 hasAuthorship W3191822012A5083765806 @default.
• W3191822012 hasAuthorship W3191822012A5085253413 @default.
• W3191822012 hasAuthorship W3191822012A5086796260 @default.
• W3191822012 hasBestOaLocation W31918220121 @default.
• W3191822012 hasConcept C117838684 @default.

• next