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• W3191834672 abstract "Complex machinery is required to drive secretory cargo export from the endoplasmic reticulum (ER), which is an essential process in eukaryotic cells. In vertebrates, the MIA3 gene encodes two major forms of transport and Golgi organization protein 1 (TANGO1S and TANGO1L), which have previously been implicated in selective trafficking of procollagen. Using genome engineering of human cells, light microscopy, secretion assays, genomics and proteomics, we show that disruption of the longer form, TANGO1L, results in relatively minor defects in secretory pathway organization and function, including having limited impacts on procollagen secretion. In contrast, loss of both long and short forms results in major defects in cell organization and secretion. These include a failure to maintain the localization of ERGIC53 (also known as LMAN1) and SURF4 to the ER-Golgi intermediate compartment and dramatic changes to the ultrastructure of the ER-Golgi interface. Disruption of TANGO1 causes significant changes in early secretory pathway gene and protein expression, and impairs secretion not only of large proteins, but of all types of secretory cargo, including small soluble proteins. Our data support a general role for MIA3/TANGO1 in maintaining secretory pathway structure and function in vertebrate cells." @default.
• W3191834672 created "2021-08-16" @default.
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• W3191834672 date "2021-09-01" @default.
• W3191834672 modified "2023-10-15" @default.
• W3191834672 title "A general role for TANGO1, encoded by <i>MIA3</i>, in secretory pathway organization and function" @default.
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• W3191834672 doi "https://doi.org/10.1242/jcs.259075" @default.
• W3191834672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8524724" @default.
• W3191834672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34350936" @default.
• W3191834672 hasPublicationYear "2021" @default.
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