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• W3191857984 abstract "Disease especially caused by White spot syndrome virus (WSSV) has a huge impact on the shrimp production industry. An understanding of shrimp-WSSV interaction could lead to an effective approach to control WSSV infection. MicroRNA (miRNA) is a short small RNA which functions in post-transcriptional gene regulation and is involved in the WSSV infection. Previously, WSSV-encoded miRNAs were identified from infected P. monodon. We investigated wsv-miR-9 which showed the highest expression in WSSV-infected gill tissue. The expression of wsv-miR-9 was up-regulated upon WSSV infection and reduced in moribund shrimp. Antisense inhibition using anti-miRNA oligonucleotides (AMO) resulted in a complete inhibition of wsv-miR-9 expression. An in vitro functional study demonstrated that mimic of wsv-miR-9 could function in translational suppression by decreasing the reporter protein activity when compared to the mutant target. In shrimp, loss of wsv-miR-9 by AMO9 resulted in a delay of viral replication after 6–12 h post WSSV challenge. A reduction of WSSV early genes, ie1 and DNA polymerase mRNA expressions was observed within 6 h. These results reveal that wsv-miR-9 is important in maintaining early viral gene expression. • Inhibiting micro-RNA wsv-miR-9 of white spot syndrome virus (WSSV) reduces viral replication. • Inhibition of wsv-miR-9 beyond 6 h after viral infection does not reduce viral replication. • Inhibition is indirectly linked to reduced expression of the WSSV early genes, ie1 and DNA-polymerase. • Thus, wsv-miR-9 appears to function by promoting WSSV at the early stage of infection." @default.
• W3191857984 created "2021-08-16" @default.
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• W3191857984 date "2022-01-01" @default.
• W3191857984 modified "2023-09-26" @default.
• W3191857984 title "White spot syndrome virus-encoded microRNA promotes viral replication by maintaining viral early gene expression" @default.
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• W3191857984 doi "https://doi.org/10.1016/j.aquaculture.2021.737284" @default.
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