Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191867154> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3191867154 endingPage "4804" @default.
- W3191867154 startingPage "4804" @default.
- W3191867154 abstract "Thymic stromal lymphopoietin (TSLP) plays an important role in the pathophysiology of various allergic diseases that are mediated by T helper cell type-2 (Th2) responses, including asthma and atopic dermatitis. The primary focus of this study was the identification of potent inhibitors of the TSLP signaling pathway for potential therapeutic use. The 80% methanol extract of Machilus thunbergii bark significantly inhibited the signal transducer and activator of transcription 5 (STAT5) phosphorylation in human mast cell (HMC)-1 cells. Through activity-guided isolation, three lignans (1–3) were obtained and identified as (+)-galbelgin (1), meso-dihydroguaiaretic acid (2), and machilin A (3). Among them, two lignans (1 and 2) significantly inhibited STAT5 phosphorylation and TSLP/TSLPR interaction, as determined by ELISA. Our results indicated that lignans isolated from M. thunbergii are a promising resource for the treatment of allergic diseases." @default.
- W3191867154 created "2021-08-16" @default.
- W3191867154 creator A5013752525 @default.
- W3191867154 creator A5045669948 @default.
- W3191867154 creator A5053445608 @default.
- W3191867154 creator A5074209511 @default.
- W3191867154 creator A5078463338 @default.
- W3191867154 date "2021-08-08" @default.
- W3191867154 modified "2023-09-25" @default.
- W3191867154 title "Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors" @default.
- W3191867154 cites W1483479982 @default.
- W3191867154 cites W1507483434 @default.
- W3191867154 cites W1510034351 @default.
- W3191867154 cites W1966056133 @default.
- W3191867154 cites W1991760919 @default.
- W3191867154 cites W2001780547 @default.
- W3191867154 cites W2002641543 @default.
- W3191867154 cites W2006493717 @default.
- W3191867154 cites W2013736574 @default.
- W3191867154 cites W2014175964 @default.
- W3191867154 cites W2015840641 @default.
- W3191867154 cites W2017557392 @default.
- W3191867154 cites W2042588031 @default.
- W3191867154 cites W2044728977 @default.
- W3191867154 cites W2056225527 @default.
- W3191867154 cites W2059473154 @default.
- W3191867154 cites W2077990797 @default.
- W3191867154 cites W2093631772 @default.
- W3191867154 cites W2100766832 @default.
- W3191867154 cites W2138775578 @default.
- W3191867154 cites W2138794826 @default.
- W3191867154 cites W2235089757 @default.
- W3191867154 cites W2605666066 @default.
- W3191867154 cites W2797787555 @default.
- W3191867154 cites W2950738412 @default.
- W3191867154 cites W2980572009 @default.
- W3191867154 cites W3009881297 @default.
- W3191867154 cites W4255915349 @default.
- W3191867154 cites W2039467243 @default.
- W3191867154 doi "https://doi.org/10.3390/molecules26164804" @default.
- W3191867154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8398558" @default.
- W3191867154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34443392" @default.
- W3191867154 hasPublicationYear "2021" @default.
- W3191867154 type Work @default.
- W3191867154 sameAs 3191867154 @default.
- W3191867154 citedByCount "0" @default.
- W3191867154 crossrefType "journal-article" @default.
- W3191867154 hasAuthorship W3191867154A5013752525 @default.
- W3191867154 hasAuthorship W3191867154A5045669948 @default.
- W3191867154 hasAuthorship W3191867154A5053445608 @default.
- W3191867154 hasAuthorship W3191867154A5074209511 @default.
- W3191867154 hasAuthorship W3191867154A5078463338 @default.
- W3191867154 hasBestOaLocation W31918671541 @default.
- W3191867154 hasConcept C11960822 @default.
- W3191867154 hasConcept C171958077 @default.
- W3191867154 hasConcept C185592680 @default.
- W3191867154 hasConcept C203014093 @default.
- W3191867154 hasConcept C2778070265 @default.
- W3191867154 hasConcept C2778329239 @default.
- W3191867154 hasConcept C2778923194 @default.
- W3191867154 hasConcept C2779391668 @default.
- W3191867154 hasConcept C55493867 @default.
- W3191867154 hasConcept C62478195 @default.
- W3191867154 hasConcept C86803240 @default.
- W3191867154 hasConcept C98274493 @default.
- W3191867154 hasConceptScore W3191867154C11960822 @default.
- W3191867154 hasConceptScore W3191867154C171958077 @default.
- W3191867154 hasConceptScore W3191867154C185592680 @default.
- W3191867154 hasConceptScore W3191867154C203014093 @default.
- W3191867154 hasConceptScore W3191867154C2778070265 @default.
- W3191867154 hasConceptScore W3191867154C2778329239 @default.
- W3191867154 hasConceptScore W3191867154C2778923194 @default.
- W3191867154 hasConceptScore W3191867154C2779391668 @default.
- W3191867154 hasConceptScore W3191867154C55493867 @default.
- W3191867154 hasConceptScore W3191867154C62478195 @default.
- W3191867154 hasConceptScore W3191867154C86803240 @default.
- W3191867154 hasConceptScore W3191867154C98274493 @default.
- W3191867154 hasIssue "16" @default.
- W3191867154 hasLocation W31918671541 @default.
- W3191867154 hasLocation W31918671542 @default.
- W3191867154 hasOpenAccess W3191867154 @default.
- W3191867154 hasPrimaryLocation W31918671541 @default.
- W3191867154 hasRelatedWork W1956528967 @default.
- W3191867154 hasRelatedWork W1968968766 @default.
- W3191867154 hasRelatedWork W2027810463 @default.
- W3191867154 hasRelatedWork W2056225527 @default.
- W3191867154 hasRelatedWork W2071274119 @default.
- W3191867154 hasRelatedWork W2091742535 @default.
- W3191867154 hasRelatedWork W2111074547 @default.
- W3191867154 hasRelatedWork W3191867154 @default.
- W3191867154 hasRelatedWork W4376595676 @default.
- W3191867154 hasRelatedWork W2140751959 @default.
- W3191867154 hasVolume "26" @default.
- W3191867154 isParatext "false" @default.
- W3191867154 isRetracted "false" @default.
- W3191867154 magId "3191867154" @default.
- W3191867154 workType "article" @default.