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- W3191878299 abstract "Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and neurodegenerative disease affecting the central nervous system (CNS), often characterized by the accumulation of irreversible clinical disability over time. During last years, there has been a dramatic evolution in several key concepts of immune pathophysiology of MS and in the treatment of this disease. The demonstration of the strong efficacy and good safety profile of selective B-cell-depleting therapies (such as anti-CD20 monoclonal antibodies) has significantly expanded the therapeutic scenario for both relapsing and progressive MS patients with the identification of a new therapeutic target. The key role of B cells in triggering MS disease has been also pointed out, determining a shift from the traditional view of MS activity as largely being 'T-cell mediated' to the notion that MS-related pathological processes involve bi-directional interactions between several immune cell types, including B cells, both in the periphery and in the CNS. This review provides an updated overview of the involvement of B cells in the immune pathophysiology and pathology of MS. We summarize the rationale regarding the use of anti-CD20 therapies and the results of the main randomized controlled trials and observational studies investigating the efficacy and safety profile of rituximab, ocrelizumab, ofatumumab and ublituximab. Suggestions regarding vaccinations and management of MS patients during COVID-19 pandemic with anti-CD20 therapies are also discussed. Finally, therapies under investigation and future perspectives of anti-CD20 therapies are taken into consideration." @default.
- W3191878299 created "2021-08-16" @default.
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- W3191878299 date "2021-08-11" @default.
- W3191878299 modified "2023-10-14" @default.
- W3191878299 title "Anti-CD20 therapies for multiple sclerosis: current status and future perspectives" @default.
- W3191878299 cites W1521119381 @default.
- W3191878299 cites W1816536644 @default.
- W3191878299 cites W1828576284 @default.
- W3191878299 cites W1970626055 @default.
- W3191878299 cites W1981621288 @default.
- W3191878299 cites W1993868490 @default.
- W3191878299 cites W2002444618 @default.
- W3191878299 cites W2013234597 @default.
- W3191878299 cites W2019182330 @default.
- W3191878299 cites W2020206181 @default.
- W3191878299 cites W2037979244 @default.
- W3191878299 cites W2048324178 @default.
- W3191878299 cites W2049872026 @default.
- W3191878299 cites W2082237468 @default.
- W3191878299 cites W2083565083 @default.
- W3191878299 cites W2086080135 @default.
- W3191878299 cites W2086450075 @default.
- W3191878299 cites W2088341378 @default.
- W3191878299 cites W2090095728 @default.
- W3191878299 cites W2099667986 @default.
- W3191878299 cites W2105167551 @default.
- W3191878299 cites W2107008240 @default.
- W3191878299 cites W2113948549 @default.
- W3191878299 cites W2117650131 @default.
- W3191878299 cites W2122542523 @default.
- W3191878299 cites W2130974415 @default.
- W3191878299 cites W2137350492 @default.
- W3191878299 cites W2141111992 @default.
- W3191878299 cites W2142577589 @default.
- W3191878299 cites W2147062889 @default.
- W3191878299 cites W2154132418 @default.
- W3191878299 cites W2160872052 @default.
- W3191878299 cites W2160920639 @default.
- W3191878299 cites W2161607126 @default.
- W3191878299 cites W2171925564 @default.
- W3191878299 cites W2230487266 @default.
- W3191878299 cites W2313484897 @default.
- W3191878299 cites W2436774897 @default.
- W3191878299 cites W2536452417 @default.
- W3191878299 cites W2556589230 @default.
- W3191878299 cites W2561881161 @default.
- W3191878299 cites W2565433170 @default.
- W3191878299 cites W2734442974 @default.
- W3191878299 cites W2769378959 @default.
- W3191878299 cites W2784268727 @default.
- W3191878299 cites W2788933778 @default.
- W3191878299 cites W2791441078 @default.
- W3191878299 cites W2791535469 @default.
- W3191878299 cites W2791833398 @default.
- W3191878299 cites W2792851064 @default.
- W3191878299 cites W2799307548 @default.
- W3191878299 cites W2802139618 @default.
- W3191878299 cites W2804050703 @default.
- W3191878299 cites W2804969367 @default.
- W3191878299 cites W2805197831 @default.
- W3191878299 cites W2807882529 @default.
- W3191878299 cites W2901272797 @default.
- W3191878299 cites W2908974689 @default.
- W3191878299 cites W2913489076 @default.
- W3191878299 cites W2919746350 @default.
- W3191878299 cites W2944582362 @default.
- W3191878299 cites W2954141460 @default.
- W3191878299 cites W2978140831 @default.
- W3191878299 cites W3006378145 @default.
- W3191878299 cites W3015781103 @default.
- W3191878299 cites W3022913130 @default.
- W3191878299 cites W3034725616 @default.
- W3191878299 cites W3045030255 @default.
- W3191878299 cites W3045825841 @default.
- W3191878299 cites W3047302551 @default.
- W3191878299 cites W3047603382 @default.
- W3191878299 cites W3047732285 @default.
- W3191878299 cites W3086814701 @default.
- W3191878299 cites W3096310943 @default.
- W3191878299 cites W3121831652 @default.
- W3191878299 cites W3137894405 @default.
- W3191878299 cites W3137944655 @default.
- W3191878299 cites W3139311115 @default.
- W3191878299 cites W3155816660 @default.
- W3191878299 cites W3165289570 @default.
- W3191878299 doi "https://doi.org/10.1007/s00415-021-10744-x" @default.
- W3191878299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8356891" @default.
- W3191878299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34382120" @default.
- W3191878299 hasPublicationYear "2021" @default.
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