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- W3191965276 abstract "The hippocampus has previously been implicated in both cognitive and endocrine functions1–15. We simultaneously measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. Here we report that clusters of sharp wave-ripples recorded from the hippocampus reliably predicted a decrease in peripheral glucose concentrations within about 10 min. This correlation was not dependent on circadian, ultradian or meal-triggered fluctuations, could be mimicked with optogenetically induced ripples in the hippocampus (but not in the parietal cortex) and was attenuated to chance levels by pharmacogenetically suppressing activity of the lateral septum, which is the major conduit between the hippocampus and the hypothalamus. Our findings demonstrate that a function of the sharp wave-ripple is to modulate peripheral glucose homeostasis, and offer a mechanism for the link between sleep disruption and blood glucose dysregulation in type 2 diabetes16–18. Sharp wave-ripples from the hippocampus are shown to modulate peripheral glucose homeostasis in rats, offering insights into the mechanism that links sleep disruption and blood glucose regulation in type 2 diabetes." @default.
- W3191965276 created "2021-08-16" @default.
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- W3191965276 date "2021-08-11" @default.
- W3191965276 modified "2023-10-15" @default.
- W3191965276 title "A metabolic function of the hippocampal sharp wave-ripple" @default.
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- W3191965276 doi "https://doi.org/10.1038/s41586-021-03811-w" @default.
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