FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192000324> ?p ?o ?g. }

• W3192000324 abstract "Breast cancer manifests in diverse forms, with particular reference to various cell types harboring different mutations and gene expression profiles. To elucidate the clonal relationship between cancer cells in tumors composed of both ductal and lobular phenotypes, two combined lobular and ductal carcinoma (CLDC) cases were analyzed, including one mixed ductal‑lobular carcinoma (MDL) lesion, by direct sequencing of the mitochondrial DNA D‑loop, digital PCR targeting of chromosomes 1q and 16q, as well as next‑generation sequencing. DNA was extracted from formalin‑fixed paraffin‑embedded tissue sections of different histological types, including invasive ductal carcinoma, invasive lobular carcinoma, ductal carcinoma in situ, lobular carcinoma in situ, flat epithelial atypia, non‑neoplastic mammary gland and extramammary organs, using laser‑assisted microdissection. Mutations detected by the comprehensive cancer panel were validated by SYBR green allele‑specific quantitative PCR (RRM1, AKT1, PIK3CA, RALGDS, EGFR, TP53, IL21R, DPYD, SGK1, CDH1, TIMP3 and KMT2C). CLDC, which shared the basic genetic alterations of 1q gain or 16q loss, progresses to invasive lobular or ductual carcinoma with the accumulation of further mutations. Cancer cells contained in an MDL lesion shared closely related genetic alterations, suggesting that these cells have the same origin, despite different histological features, namely 'lobular' or 'ductal'. By contrast, multiple lesions located away from the main tumor, diagnosed as CLDC (excluding an MDL lesion) were not always identical with different genetic alterations, despite being diagnosed as ductal carcinoma in situ. Thus, MDL should be defined as a distinct category separate from CLDC, whose components of 'lobular' and 'ductal' may have the same cellular origin." @default.
• W3192000324 created "2021-08-16" @default.
• W3192000324 creator A5001665110 @default.
• W3192000324 creator A5006288077 @default.
• W3192000324 creator A5011487286 @default.
• W3192000324 creator A5012770535 @default.
• W3192000324 creator A5065037266 @default.
• W3192000324 date "2021-08-10" @default.
• W3192000324 modified "2023-10-16" @default.
• W3192000324 title "Phylogenetic analysis of combined lobular and ductal carcinoma of the breast" @default.
• W3192000324 cites W1518489189 @default.
• W3192000324 cites W1526705543 @default.
• W3192000324 cites W1921074952 @default.
• W3192000324 cites W1998728654 @default.
• W3192000324 cites W2004425251 @default.
• W3192000324 cites W2021456586 @default.
• W3192000324 cites W2023560061 @default.
• W3192000324 cites W2027181440 @default.
• W3192000324 cites W2029146706 @default.
• W3192000324 cites W2048646241 @default.
• W3192000324 cites W2050276844 @default.
• W3192000324 cites W2052532932 @default.
• W3192000324 cites W2060965437 @default.
• W3192000324 cites W2066710246 @default.
• W3192000324 cites W2066726027 @default.
• W3192000324 cites W2075973896 @default.
• W3192000324 cites W2076173229 @default.
• W3192000324 cites W2081538075 @default.
• W3192000324 cites W2096283457 @default.
• W3192000324 cites W2097255042 @default.
• W3192000324 cites W2106314624 @default.
• W3192000324 cites W2109991075 @default.
• W3192000324 cites W2110578052 @default.
• W3192000324 cites W2114570899 @default.
• W3192000324 cites W2118728607 @default.
• W3192000324 cites W2122197597 @default.
• W3192000324 cites W2125401785 @default.
• W3192000324 cites W2131994307 @default.
• W3192000324 cites W2141393790 @default.
• W3192000324 cites W2159459001 @default.
• W3192000324 cites W2293032062 @default.
• W3192000324 cites W2613808212 @default.
• W3192000324 cites W2793538361 @default.
• W3192000324 cites W2891700678 @default.
• W3192000324 cites W2912993657 @default.
• W3192000324 cites W2965857754 @default.
• W3192000324 cites W3184020198 @default.
• W3192000324 cites W3217485783 @default.
• W3192000324 doi "https://doi.org/10.3892/mmr.2021.12357" @default.
• W3192000324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8383046" @default.
• W3192000324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34396426" @default.
• W3192000324 hasPublicationYear "2021" @default.
• W3192000324 type Work @default.
• W3192000324 sameAs 3192000324 @default.
• W3192000324 citedByCount "1" @default.
• W3192000324 countsByYear W31920003242023 @default.
• W3192000324 crossrefType "journal-article" @default.
• W3192000324 hasAuthorship W3192000324A5001665110 @default.
• W3192000324 hasAuthorship W3192000324A5006288077 @default.
• W3192000324 hasAuthorship W3192000324A5011487286 @default.
• W3192000324 hasAuthorship W3192000324A5012770535 @default.
• W3192000324 hasAuthorship W3192000324A5065037266 @default.
• W3192000324 hasBestOaLocation W31920003241 @default.
• W3192000324 hasConcept C104317684 @default.
• W3192000324 hasConcept C11242284 @default.
• W3192000324 hasConcept C121608353 @default.
• W3192000324 hasConcept C125965507 @default.
• W3192000324 hasConcept C142724271 @default.
• W3192000324 hasConcept C150194340 @default.
• W3192000324 hasConcept C2776372563 @default.
• W3192000324 hasConcept C2777546739 @default.
• W3192000324 hasConcept C2779296616 @default.
• W3192000324 hasConcept C2780862961 @default.
• W3192000324 hasConcept C3020375857 @default.
• W3192000324 hasConcept C502942594 @default.
• W3192000324 hasConcept C530470458 @default.
• W3192000324 hasConcept C54355233 @default.
• W3192000324 hasConcept C71924100 @default.
• W3192000324 hasConcept C86803240 @default.
• W3192000324 hasConceptScore W3192000324C104317684 @default.
• W3192000324 hasConceptScore W3192000324C11242284 @default.
• W3192000324 hasConceptScore W3192000324C121608353 @default.
• W3192000324 hasConceptScore W3192000324C125965507 @default.
• W3192000324 hasConceptScore W3192000324C142724271 @default.
• W3192000324 hasConceptScore W3192000324C150194340 @default.
• W3192000324 hasConceptScore W3192000324C2776372563 @default.
• W3192000324 hasConceptScore W3192000324C2777546739 @default.
• W3192000324 hasConceptScore W3192000324C2779296616 @default.
• W3192000324 hasConceptScore W3192000324C2780862961 @default.
• W3192000324 hasConceptScore W3192000324C3020375857 @default.
• W3192000324 hasConceptScore W3192000324C502942594 @default.
• W3192000324 hasConceptScore W3192000324C530470458 @default.
• W3192000324 hasConceptScore W3192000324C54355233 @default.
• W3192000324 hasConceptScore W3192000324C71924100 @default.
• W3192000324 hasConceptScore W3192000324C86803240 @default.
• W3192000324 hasIssue "4" @default.
• W3192000324 hasLocation W31920003241 @default.
• W3192000324 hasLocation W31920003242 @default.
• W3192000324 hasLocation W31920003243 @default.
• W3192000324 hasOpenAccess W3192000324 @default.

• next