Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192049498> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3192049498 endingPage "849" @default.
- W3192049498 startingPage "849" @default.
- W3192049498 abstract "Porcine reproductive and respiratory syndrome (PRRS) is a globally spread, highly infectious viral disease. Live, attenuated vaccines against PRRS virus (PRRSV) decrease virus excretion and evoke protective immunity reducing the economic damage caused by the disease. In a longitudinal molecular epidemiological study accompanying ongoing national eradication programme we evaluated the suitability of PRRSV ORF5 and ORF7 sequences to identify possible field strains of vaccine-origin. In total, 2342 ORF5 sequences and 478 ORF7 sequences were analysed. Vaccine strains were identified by sequence identity values and phylogenetic network analysis. Strains that shared greater than 98% nucleotide identity within ORF5 and/or ORF7 were considered to have originated from vaccine. A total of 882 (37.6%) ORF5 and 88 (18.4%) ORF7 sequences met these criteria. In detail, 618, 179 and 35 ORF5 and 51, 29 and 8 ORF7 sequences were related to Porcilis PRRS vaccine, Unistrain PRRS vaccine, and ReproCyc PRRS EU vaccine, respectively. Data showed that the Porcilis vaccine was genetically more stable. Whereas, the variability of the Unistrain and the ReproCyc strains was significantly higher. Given that ORF7 shares, in some instances, complete identity between a particular vaccine strain and some historic variants of field PRRSV strains, care must be taken when evaluating vaccine relatedness of a field isolate based on the ORF7. On the contrary, ORF5 sequences were more suitable to predict the vaccine origin making a distinction more robustly between field and vaccine strains. We conclude that ORF5 based molecular epidemiological studies support more efficiently the ongoing PRRS eradication programmes. The conclusions presented in this large-scale PRRS molecular epidemiological study provides a framework for future eradication programmes planned in other countries." @default.
- W3192049498 created "2021-08-16" @default.
- W3192049498 creator A5000533053 @default.
- W3192049498 creator A5007486351 @default.
- W3192049498 creator A5021248984 @default.
- W3192049498 creator A5031577099 @default.
- W3192049498 creator A5069681133 @default.
- W3192049498 creator A5074401641 @default.
- W3192049498 creator A5079611560 @default.
- W3192049498 creator A5082236738 @default.
- W3192049498 creator A5084787744 @default.
- W3192049498 creator A5085376268 @default.
- W3192049498 creator A5090983796 @default.
- W3192049498 date "2021-08-03" @default.
- W3192049498 modified "2023-10-18" @default.
- W3192049498 title "Genetic Variability of PRRSV Vaccine Strains Used in the National Eradication Programme, Hungary" @default.
- W3192049498 cites W1966793459 @default.
- W3192049498 cites W1992489909 @default.
- W3192049498 cites W2000742077 @default.
- W3192049498 cites W2005514695 @default.
- W3192049498 cites W2005829501 @default.
- W3192049498 cites W2022506220 @default.
- W3192049498 cites W2033745025 @default.
- W3192049498 cites W2046274883 @default.
- W3192049498 cites W2071154020 @default.
- W3192049498 cites W2073857833 @default.
- W3192049498 cites W2118115302 @default.
- W3192049498 cites W2142467502 @default.
- W3192049498 cites W2153999413 @default.
- W3192049498 cites W2168254025 @default.
- W3192049498 cites W2238711257 @default.
- W3192049498 cites W2609505966 @default.
- W3192049498 cites W2800966807 @default.
- W3192049498 cites W2951515899 @default.
- W3192049498 cites W3097671409 @default.
- W3192049498 cites W3102102732 @default.
- W3192049498 doi "https://doi.org/10.3390/vaccines9080849" @default.
- W3192049498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8402617" @default.
- W3192049498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34451974" @default.
- W3192049498 hasPublicationYear "2021" @default.
- W3192049498 type Work @default.
- W3192049498 sameAs 3192049498 @default.
- W3192049498 citedByCount "3" @default.
- W3192049498 countsByYear W31920494982022 @default.
- W3192049498 crossrefType "journal-article" @default.
- W3192049498 hasAuthorship W3192049498A5000533053 @default.
- W3192049498 hasAuthorship W3192049498A5007486351 @default.
- W3192049498 hasAuthorship W3192049498A5021248984 @default.
- W3192049498 hasAuthorship W3192049498A5031577099 @default.
- W3192049498 hasAuthorship W3192049498A5069681133 @default.
- W3192049498 hasAuthorship W3192049498A5074401641 @default.
- W3192049498 hasAuthorship W3192049498A5079611560 @default.
- W3192049498 hasAuthorship W3192049498A5082236738 @default.
- W3192049498 hasAuthorship W3192049498A5084787744 @default.
- W3192049498 hasAuthorship W3192049498A5085376268 @default.
- W3192049498 hasAuthorship W3192049498A5090983796 @default.
- W3192049498 hasBestOaLocation W31920494981 @default.
- W3192049498 hasConcept C104317684 @default.
- W3192049498 hasConcept C159047783 @default.
- W3192049498 hasConcept C193252679 @default.
- W3192049498 hasConcept C2522874641 @default.
- W3192049498 hasConcept C54355233 @default.
- W3192049498 hasConcept C54602769 @default.
- W3192049498 hasConcept C60987743 @default.
- W3192049498 hasConcept C86803240 @default.
- W3192049498 hasConceptScore W3192049498C104317684 @default.
- W3192049498 hasConceptScore W3192049498C159047783 @default.
- W3192049498 hasConceptScore W3192049498C193252679 @default.
- W3192049498 hasConceptScore W3192049498C2522874641 @default.
- W3192049498 hasConceptScore W3192049498C54355233 @default.
- W3192049498 hasConceptScore W3192049498C54602769 @default.
- W3192049498 hasConceptScore W3192049498C60987743 @default.
- W3192049498 hasConceptScore W3192049498C86803240 @default.
- W3192049498 hasIssue "8" @default.
- W3192049498 hasLocation W31920494981 @default.
- W3192049498 hasLocation W31920494982 @default.
- W3192049498 hasOpenAccess W3192049498 @default.
- W3192049498 hasPrimaryLocation W31920494981 @default.
- W3192049498 hasRelatedWork W1874513932 @default.
- W3192049498 hasRelatedWork W2016551366 @default.
- W3192049498 hasRelatedWork W2094230406 @default.
- W3192049498 hasRelatedWork W2099377822 @default.
- W3192049498 hasRelatedWork W2111970140 @default.
- W3192049498 hasRelatedWork W2123163123 @default.
- W3192049498 hasRelatedWork W2138564085 @default.
- W3192049498 hasRelatedWork W2147145791 @default.
- W3192049498 hasRelatedWork W2188759708 @default.
- W3192049498 hasRelatedWork W4386371748 @default.
- W3192049498 hasVolume "9" @default.
- W3192049498 isParatext "false" @default.
- W3192049498 isRetracted "false" @default.
- W3192049498 magId "3192049498" @default.
- W3192049498 workType "article" @default.