FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192052007> ?p ?o ?g. }

• W3192052007 abstract "Malaria caused by Plasmodium species and transmitted by Anopheles mosquitoes affects large human populations, while Ixodes ticks transmit Babesia species and cause babesiosis. Babesiosis in animals has been known as an economic drain, and human disease has also emerged as a serious healthcare problem in the last 20–30 years. There is limited literature available regarding pathogenesis, immunity, and disease caused by Babesia spp. with their genomes sequenced only in the last decade. Therefore, using previous studies on Plasmodium as the foundation, we have compared similarities and differences in the pathogenesis of Babesia and host immune responses. Sexual life cycles of these two hemoparasites in their respective vectors are quite similar. An adult Anopheles female can take blood meal several times in its life such that it can both acquire and transmit Plasmodia to hosts. Since each tick stage takes blood meal only once, transstadial horizontal transmission from larva to nymph or nymph to adult is essential for the release of Babesia into the host. The initiation of the asexual cycle of these parasites is different because Plasmodium sporozoites need to infect hepatocytes before egressed merozoites can infect erythrocytes, while Babesia sporozoites are known to enter the erythrocytic cycle directly. Plasmodium metabolism, as determined by its two- to threefold larger genome than different Babesia , is more complex. Plasmodium replication occurs in parasitophorous vacuole (PV) within the host cells, and a relatively large number of merozoites are released from each infected RBC after schizogony. The Babesia erythrocytic cycle lacks both PV and schizogony. Cytoadherence that allows the sequestration of Plasmodia, primarily P. falciparum in different organs facilitated by prominent adhesins, has not been documented for Babesia yet. Inflammatory immune responses contribute to the severity of malaria and babesiosis. Antibodies appear to play only a minor role in the resolution of these diseases; however, cellular and innate immunity are critical for the clearance of both pathogens. Inflammatory immune responses affect the severity of both diseases. Macrophages facilitate the resolution of both infections and also offer cross-protection against related protozoa. Although the immunosuppression of adaptive immune responses by these parasites does not seem to affect their own clearance, it significantly exacerbates diseases caused by coinfecting bacteria during coinfections." @default.
• W3192052007 created "2021-08-16" @default.
• W3192052007 creator A5036860065 @default.
• W3192052007 creator A5040643086 @default.
• W3192052007 creator A5072569683 @default.
• W3192052007 date "2021-08-03" @default.
• W3192052007 modified "2023-10-06" @default.
• W3192052007 title "Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites: Plasmodium and Babesia" @default.
• W3192052007 cites W1015915043 @default.
• W3192052007 cites W1488895268 @default.
• W3192052007 cites W1604886088 @default.
• W3192052007 cites W1824987593 @default.
• W3192052007 cites W1905006012 @default.
• W3192052007 cites W1908153401 @default.
• W3192052007 cites W1911382205 @default.
• W3192052007 cites W1940007737 @default.
• W3192052007 cites W1964629907 @default.
• W3192052007 cites W1966311101 @default.
• W3192052007 cites W1968656383 @default.
• W3192052007 cites W1975597087 @default.
• W3192052007 cites W1981409138 @default.
• W3192052007 cites W1986159395 @default.
• W3192052007 cites W1988170203 @default.
• W3192052007 cites W2013232647 @default.
• W3192052007 cites W2015738231 @default.
• W3192052007 cites W2019190423 @default.
• W3192052007 cites W2019851585 @default.
• W3192052007 cites W2030346122 @default.
• W3192052007 cites W2031927049 @default.
• W3192052007 cites W2036529104 @default.
• W3192052007 cites W2037166560 @default.
• W3192052007 cites W2042130302 @default.
• W3192052007 cites W2044423983 @default.
• W3192052007 cites W2044869144 @default.
• W3192052007 cites W2045151339 @default.
• W3192052007 cites W2047602978 @default.
• W3192052007 cites W2047725214 @default.
• W3192052007 cites W2047745831 @default.
• W3192052007 cites W2057652826 @default.
• W3192052007 cites W2057828586 @default.
• W3192052007 cites W2059193305 @default.
• W3192052007 cites W2059387693 @default.
• W3192052007 cites W2069312954 @default.
• W3192052007 cites W2070918113 @default.
• W3192052007 cites W2071583406 @default.
• W3192052007 cites W2073132533 @default.
• W3192052007 cites W2074576245 @default.
• W3192052007 cites W2076000327 @default.
• W3192052007 cites W2076639392 @default.
• W3192052007 cites W2078156674 @default.
• W3192052007 cites W2078513186 @default.
• W3192052007 cites W2088003485 @default.
• W3192052007 cites W2091018136 @default.
• W3192052007 cites W2091367903 @default.
• W3192052007 cites W2092487651 @default.
• W3192052007 cites W2092566465 @default.
• W3192052007 cites W2100083226 @default.
• W3192052007 cites W2101197060 @default.
• W3192052007 cites W2101595934 @default.
• W3192052007 cites W2106222778 @default.
• W3192052007 cites W2107004072 @default.
• W3192052007 cites W2107296838 @default.
• W3192052007 cites W2108124558 @default.
• W3192052007 cites W2109982683 @default.
• W3192052007 cites W2117137797 @default.
• W3192052007 cites W2122742309 @default.
• W3192052007 cites W2124282820 @default.
• W3192052007 cites W2136187101 @default.
• W3192052007 cites W2137510730 @default.
• W3192052007 cites W2142657250 @default.
• W3192052007 cites W2143408603 @default.
• W3192052007 cites W2147009216 @default.
• W3192052007 cites W2160891320 @default.
• W3192052007 cites W2162460181 @default.
• W3192052007 cites W2164889791 @default.
• W3192052007 cites W2165199797 @default.
• W3192052007 cites W2165594194 @default.
• W3192052007 cites W2167221432 @default.
• W3192052007 cites W2170032605 @default.
• W3192052007 cites W2172048366 @default.
• W3192052007 cites W2172258104 @default.
• W3192052007 cites W2176173130 @default.
• W3192052007 cites W2190571495 @default.
• W3192052007 cites W2191591303 @default.
• W3192052007 cites W2191815962 @default.
• W3192052007 cites W2244652912 @default.
• W3192052007 cites W2254654087 @default.
• W3192052007 cites W2286548552 @default.
• W3192052007 cites W2331917077 @default.
• W3192052007 cites W2344640479 @default.
• W3192052007 cites W2417903492 @default.
• W3192052007 cites W2466460457 @default.
• W3192052007 cites W2519004769 @default.
• W3192052007 cites W2528984428 @default.
• W3192052007 cites W2531001238 @default.
• W3192052007 cites W2560296531 @default.
• W3192052007 cites W2560808412 @default.
• W3192052007 cites W2577260027 @default.
• W3192052007 cites W2578730893 @default.
• W3192052007 cites W2588212781 @default.

• next