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- W3192108572 abstract "Objective: To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-13 (MMP-13) in bullous pemphigoid (BP) skin lesions. Methods: Immunohistochemical SP method was used to detect the expression of MMP-2 and MMP-13 in 32 BP skin lesions, and compared with 15 normal skin tissues. Results: The expression of MMP-2 in the case group was significantly increased (38.56 ± 10.06) compared to the normal control group (21.20 ± 5.98); the expression of MMP-13 in the case group was significantly augmented (18.62 ± 5.90) compared to the normal control group (11.47 ± 8.484). The expressions of MMP-2 and MMP-13 in the skin lesions of patients with bullous pemphigoid were statistically different from those of normal people (both P < 0.05). Compared with the expression of MMP-2 and MMP-13 in bullous pemphigoid, the expression of MMP-2 and MMP-13 was moderately correlated (correlation coefficient was 0.523). Conclusion: The expression of MMP-2 and MMP-13 is significantly increased in bullous pemphigoid skin lesions, suggesting that they may play an important role in the pathogenesis of BP. There is a certain correlation between the expression of MMP-2 and MMP-13, suggesting that the high expression of MMP-13 may play a role in the mechanism that further leads to the high expression of MMP-2." @default.
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- W3192108572 date "2019-12-20" @default.
- W3192108572 modified "2023-09-26" @default.
- W3192108572 title "Expression of MMP-2 and MMP-13 in Bullous Pemphigoid" @default.
- W3192108572 doi "https://doi.org/10.26689/jcnr.v4i1.987" @default.
- W3192108572 hasPublicationYear "2019" @default.
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