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- W3192152028 abstract "Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential for cell differentiation and polarized morphogenesis. However, their functions in plant pathogenic fungi are not well understood. Here, we characterized the NDR kinase FgCot1 and its activator FgMob2 in Fusarium graminearum, a major pathogen causing Fusarium head blight (FHB) in wheat. FgCot1 and FgMob2 formed a NDR kinase-MOB protein complex. Localization assays using FgCot1-GFP or FgMob2-RFP constructs showed diverse subcellular localizations, including cytoplasm, septum, nucleus and hyphal tip. ΔFgcot1 and ΔFgmob2 exhibited serious defects in hyphal growth, polarity, fungal development and cell wall integrity as well as reduced virulence in planta. In contrast, lipid droplet accumulation was significantly increased in these two mutants. Phosphorylation of FgCot1 at two highly conserved residues (S462 and T630) as well as five new sites synergistically contributed its role in various cellular processes. In addition, non-synonymous mutations in two MAPK (mitogen-activated protein kinase) proteins, FgSte11 and FgGpmk1, partially rescued the growth defect of ΔFgmob2, indicating a functional link between the FgCot1-Mob2 complex and the FgGpmk1 signalling pathway in regulating filamentous fungal growth. These results indicated that the FgCot1-Mob2 complex is critical for polarity, fungal development, cell wall organization, lipid metabolism and virulence in F. graminearum." @default.
- W3192152028 created "2021-08-16" @default.
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- W3192152028 date "2021-08-09" @default.
- W3192152028 modified "2023-09-25" @default.
- W3192152028 title "The <scp>NDR kinase–MOB</scp> complex <scp>FgCot1‐Mob2</scp> regulates polarity and lipid metabolism in <i>Fusarium graminearum</i>" @default.
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- W3192152028 cites W1635224287 @default.
- W3192152028 cites W1792835221 @default.
- W3192152028 cites W1819527132 @default.
- W3192152028 cites W1943255417 @default.
- W3192152028 cites W1966338855 @default.
- W3192152028 cites W1969458927 @default.
- W3192152028 cites W1973444076 @default.
- W3192152028 cites W1977885289 @default.
- W3192152028 cites W1980959403 @default.
- W3192152028 cites W1985001103 @default.
- W3192152028 cites W1998793813 @default.
- W3192152028 cites W1998920538 @default.
- W3192152028 cites W1999600672 @default.
- W3192152028 cites W1999770018 @default.
- W3192152028 cites W2008054941 @default.
- W3192152028 cites W2009772827 @default.
- W3192152028 cites W2012698880 @default.
- W3192152028 cites W2026273381 @default.
- W3192152028 cites W2027942595 @default.
- W3192152028 cites W2028789015 @default.
- W3192152028 cites W2028811350 @default.
- W3192152028 cites W2044994826 @default.
- W3192152028 cites W2045073554 @default.
- W3192152028 cites W2047791387 @default.
- W3192152028 cites W2048899019 @default.
- W3192152028 cites W2052560000 @default.
- W3192152028 cites W2070517400 @default.
- W3192152028 cites W2070916151 @default.
- W3192152028 cites W2072090665 @default.
- W3192152028 cites W2073240722 @default.
- W3192152028 cites W2082143788 @default.
- W3192152028 cites W2082692750 @default.
- W3192152028 cites W2084250853 @default.
- W3192152028 cites W2086088421 @default.
- W3192152028 cites W2088040222 @default.
- W3192152028 cites W2088148959 @default.
- W3192152028 cites W2103775801 @default.
- W3192152028 cites W2105793900 @default.
- W3192152028 cites W2106013763 @default.
- W3192152028 cites W2111756560 @default.
- W3192152028 cites W2119228206 @default.
- W3192152028 cites W2120767133 @default.
- W3192152028 cites W2127464671 @default.
- W3192152028 cites W2131372853 @default.
- W3192152028 cites W2131428557 @default.
- W3192152028 cites W2132518731 @default.
- W3192152028 cites W2133688401 @default.
- W3192152028 cites W2136625993 @default.
- W3192152028 cites W2140816330 @default.
- W3192152028 cites W2141573544 @default.
- W3192152028 cites W2145538587 @default.
- W3192152028 cites W2150819706 @default.
- W3192152028 cites W2155290094 @default.
- W3192152028 cites W2155821939 @default.
- W3192152028 cites W2158047771 @default.
- W3192152028 cites W2158688606 @default.
- W3192152028 cites W2159891542 @default.
- W3192152028 cites W2160130378 @default.
- W3192152028 cites W2160795918 @default.
- W3192152028 cites W2166193187 @default.
- W3192152028 cites W2166356970 @default.
- W3192152028 cites W2167039031 @default.
- W3192152028 cites W2167502710 @default.
- W3192152028 cites W2167899780 @default.
- W3192152028 cites W2168868473 @default.
- W3192152028 cites W2333761520 @default.
- W3192152028 cites W2577240095 @default.
- W3192152028 cites W2584842235 @default.
- W3192152028 cites W2914224925 @default.
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- W3192152028 doi "https://doi.org/10.1111/1462-2920.15698" @default.
- W3192152028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34347361" @default.
- W3192152028 hasPublicationYear "2021" @default.
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