FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192156601> ?p ?o ?g. }

• W3192156601 abstract "Abstract Study question Is there an impact of recombinant luteinizing-hormone (rLH) administration timing during controlled ovarian stimulation (COS) on ovarian response and intracytoplasmic sperm injection (ICSI) cycles outcomes? Summary answer rLH supplementation in patients with poor ovarian response (POR) improves laboratorial and clinical outcomes when started in the mid-follicular phase, in GnRH antagonist ICSI cycles. What is known already Meta-analyses demonstrated that the use of rLH combined with rFSH for COS may lead to more ongoing pregnancies than rFSH alone. However, there is limited evidence that the timing of rLH addition to rFSH may impact the ovarian response or the outcomes of ICSI, based on a limited casuistic, which demonstrated improved ovarian response, embryo quality and pregnancy rate with LH supplementation from GnRH antagonist administration day, in estimated POR patients. The objective of the present study was to further investigate this hypothesis in a larger population, and in subpopulations of patients stratified by age and response to COS. Study design, size, duration This historical cohort study included data obtained via chart review of 1278 ICSI cycles performed in 1278 patients between 2015 and 2018, in a private university-affiliated in vitro fertilization center. Post hoc power analysis was calculated, given α of 5%, sample size of 1278, and effect size for implantation rate. The achieved power was superior to 99%. Participants/materials, setting, methods Two groups were formed according to timing of LH administration: Group LH-start (n = 323), in which LH was started on day–1; and Group LH-mid (n = 955), in which LH was started with GnRH antagonist. Then, data were stratified according to female age (&lt;35 years-old, n = 283, and ≥35 years-old, n = 995) and response to COS (poor response (POR): ≤4 retrieved oocytes, n = 423, and normal response: &gt;5 retrieved oocytes, n = 855). Ovarian response and ICSI outcomes were compared among the groups. Main results and the role of chance In POR patients, significantly higher fertilization rate (68.3% ± 2.5 vs. 78.6% ± 3.7, p = 0.023), blastocyst development rate (22.5% ± 7.2 vs. 44.7% ± 6.2, p = 0.022) and implantation rate (17.6% ± 59.1 vs. 20.2% ± 43.2, p &lt; 0.001) were observed in Group LH-mid, even though the amount of LH used in these patients was not significant different from that used in Group LH-mid from patients with normal response to COS (1062.35 IU ± 54.33 vs. 925.81 IU ± 414.41, p: 0.431, respectively). For the general group and in patients aged ≥ 35 years, higher blastocyst development rates were observed in Group LH-mid compared to Group LH-start (33.0% ± 31.9 vs. 40.8% ± 32.6, p = 0.012, and 28.8% ± 30.4 vs 38.5% ± 32.3, p = 0.006, respectively). In patients aged &lt; 35 years and in those with normal response to COS, similar outcomes were obtained irrespective of timing of LH administration. Limitations, reasons for caution The limitations included the retrospective design and limited sample size in subpopulations. In addition, the reduced clinical outcomes related to POR patients may hamper the true estimation of the differences between the stimulation groups in terms of pregnancy and miscarriage rates. Wider implications of the findings: In POR patients, mid-follicular phase LH supplementation starting with 150 IU daily doses, may rescue the ongoing cycle by compensating an initial slow response, and balancing the deprivation of endogenous LH in GnRH antagonist cycles, with no need of expending more gonadotropin compared to patients with normal response to COS. Trial registration number Not applicable" @default.
• W3192156601 created "2021-08-16" @default.
• W3192156601 creator A5042875708 @default.
• W3192156601 creator A5047480490 @default.
• W3192156601 creator A5052144207 @default.
• W3192156601 creator A5090976681 @default.
• W3192156601 date "2021-07-01" @default.
• W3192156601 modified "2023-09-23" @default.
• W3192156601 title "P–594 Ovarian stimulation with luteinizing hormone supplementation: the impact of timing on ovarian response and ICSI outcomes" @default.
• W3192156601 doi "https://doi.org/10.1093/humrep/deab130.593" @default.
• W3192156601 hasPublicationYear "2021" @default.
• W3192156601 type Work @default.
• W3192156601 sameAs 3192156601 @default.
• W3192156601 citedByCount "0" @default.
• W3192156601 crossrefType "journal-article" @default.
• W3192156601 hasAuthorship W3192156601A5042875708 @default.
• W3192156601 hasAuthorship W3192156601A5047480490 @default.
• W3192156601 hasAuthorship W3192156601A5052144207 @default.
• W3192156601 hasAuthorship W3192156601A5090976681 @default.
• W3192156601 hasConcept C126322002 @default.
• W3192156601 hasConcept C16685009 @default.
• W3192156601 hasConcept C187785154 @default.
• W3192156601 hasConcept C2776600139 @default.
• W3192156601 hasConcept C2777688143 @default.
• W3192156601 hasConcept C2777886879 @default.
• W3192156601 hasConcept C2778278907 @default.
• W3192156601 hasConcept C2778279030 @default.
• W3192156601 hasConcept C2778575703 @default.
• W3192156601 hasConcept C2778894405 @default.
• W3192156601 hasConcept C2779192864 @default.
• W3192156601 hasConcept C2779234561 @default.
• W3192156601 hasConcept C2908647359 @default.
• W3192156601 hasConcept C29456083 @default.
• W3192156601 hasConcept C46699223 @default.
• W3192156601 hasConcept C512716672 @default.
• W3192156601 hasConcept C54355233 @default.
• W3192156601 hasConcept C71315377 @default.
• W3192156601 hasConcept C71924100 @default.
• W3192156601 hasConcept C86803240 @default.
• W3192156601 hasConcept C99454951 @default.
• W3192156601 hasConceptScore W3192156601C126322002 @default.
• W3192156601 hasConceptScore W3192156601C16685009 @default.
• W3192156601 hasConceptScore W3192156601C187785154 @default.
• W3192156601 hasConceptScore W3192156601C2776600139 @default.
• W3192156601 hasConceptScore W3192156601C2777688143 @default.
• W3192156601 hasConceptScore W3192156601C2777886879 @default.
• W3192156601 hasConceptScore W3192156601C2778278907 @default.
• W3192156601 hasConceptScore W3192156601C2778279030 @default.
• W3192156601 hasConceptScore W3192156601C2778575703 @default.
• W3192156601 hasConceptScore W3192156601C2778894405 @default.
• W3192156601 hasConceptScore W3192156601C2779192864 @default.
• W3192156601 hasConceptScore W3192156601C2779234561 @default.
• W3192156601 hasConceptScore W3192156601C2908647359 @default.
• W3192156601 hasConceptScore W3192156601C29456083 @default.
• W3192156601 hasConceptScore W3192156601C46699223 @default.
• W3192156601 hasConceptScore W3192156601C512716672 @default.
• W3192156601 hasConceptScore W3192156601C54355233 @default.
• W3192156601 hasConceptScore W3192156601C71315377 @default.
• W3192156601 hasConceptScore W3192156601C71924100 @default.
• W3192156601 hasConceptScore W3192156601C86803240 @default.
• W3192156601 hasConceptScore W3192156601C99454951 @default.
• W3192156601 hasIssue "Supplement_1" @default.
• W3192156601 hasLocation W31921566011 @default.
• W3192156601 hasOpenAccess W3192156601 @default.
• W3192156601 hasPrimaryLocation W31921566011 @default.
• W3192156601 hasRelatedWork W12603312 @default.
• W3192156601 hasRelatedWork W1632192 @default.
• W3192156601 hasRelatedWork W1805437 @default.
• W3192156601 hasRelatedWork W18394881 @default.
• W3192156601 hasRelatedWork W18698962 @default.
• W3192156601 hasRelatedWork W19961564 @default.
• W3192156601 hasRelatedWork W7157856 @default.
• W3192156601 hasRelatedWork W17724922 @default.
• W3192156601 hasRelatedWork W18320281 @default.
• W3192156601 hasRelatedWork W20960591 @default.
• W3192156601 hasVolume "36" @default.
• W3192156601 isParatext "false" @default.
• W3192156601 isRetracted "false" @default.
• W3192156601 magId "3192156601" @default.
• W3192156601 workType "article" @default.