FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192170398> ?p ?o ?g. }

• W3192170398 abstract "ABSTRACT Segmented RNA viruses are a taxonomically diverse group of 11 families that can infect plant, wildlife, livestock and human hosts. A shared feature of these viruses is the ability to exchange genome segments during co-infection of a host by a process termed ‘reassortment’. Reassortment enables rapid evolutionary change, but in the case of segmented RNA viruses utilising an arthropod vector is set against the constraint of purifying selection and genetic bottlenecks imposed by replication in two evolutionarily distant hosts. In this study, we use an in vivo host: arbovirus: vector model to investigate the impact of reassortment on two phenotypic traits: vector competence and virulence in the host. Bluetongue virus (BTV) ( Reoviridae ) is the causative agent of bluetongue (BT), an economically important disease of domestic and wild ruminants and deer. The genome of BTV is comprised of 10 linear segments of dsRNA and the virus is transmitted between ruminants by Culicoides biting midges (Diptera: Ceratopogonidae). Five strains of BTV representing three serotypes (BTV-1, BTV-4 and BTV-8) were isolated from naturally infected ruminants in Europe and parental/reassortant lineage status assigned through full genome sequencing. Each strain was then assessed in parallel for the ability to infect Culicoides and to cause BT in sheep. Our results demonstrate that two reassortment strains, which themselves became established in the field, had obtained high replication ability in C. sonorensis from one of the parental virus strains which allowed inferences of the genome segments conferring this phenotypic trait. IMPORTANCE Reassortment between strains can lead to major shifts in the transmission parameters and virulence of segmented RNA viruses with consequences for spread, persistence and impact. The ability of these pathogens to change their phenotypes rapidly in response to selection pressure in new environments presents a major challenge in understanding factors driving emergence. Utilising a natural mammalian host-insect vector infection and transmission model, we demonstrated for the first time the genetic basis for a phenotypic trait of BTV within strains directly isolated from the field and, hence, selected and relevant for natural transmission." @default.
• W3192170398 created "2021-08-16" @default.
• W3192170398 creator A5000032892 @default.
• W3192170398 creator A5019661133 @default.
• W3192170398 creator A5033878605 @default.
• W3192170398 creator A5036978602 @default.
• W3192170398 creator A5043184761 @default.
• W3192170398 creator A5045977099 @default.
• W3192170398 creator A5057473582 @default.
• W3192170398 creator A5071022972 @default.
• W3192170398 date "2021-08-11" @default.
• W3192170398 modified "2023-10-16" @default.
• W3192170398 title "Natural reassortment of a segmented RNA arbovirus illustrates plasticity of phenotype in the arthropod vector and mammalian host<i>in vivo</i>" @default.
• W3192170398 cites W1506043252 @default.
• W3192170398 cites W1567607985 @default.
• W3192170398 cites W1574951703 @default.
• W3192170398 cites W1890318152 @default.
• W3192170398 cites W1979864969 @default.
• W3192170398 cites W1983504528 @default.
• W3192170398 cites W1988693758 @default.
• W3192170398 cites W1992351854 @default.
• W3192170398 cites W1996028819 @default.
• W3192170398 cites W2003514118 @default.
• W3192170398 cites W2016433895 @default.
• W3192170398 cites W2050651691 @default.
• W3192170398 cites W2051348515 @default.
• W3192170398 cites W2067343287 @default.
• W3192170398 cites W2067567828 @default.
• W3192170398 cites W2068454136 @default.
• W3192170398 cites W2068687644 @default.
• W3192170398 cites W2070768817 @default.
• W3192170398 cites W2074353291 @default.
• W3192170398 cites W2074760274 @default.
• W3192170398 cites W2075191596 @default.
• W3192170398 cites W2079017249 @default.
• W3192170398 cites W2079656551 @default.
• W3192170398 cites W2092608029 @default.
• W3192170398 cites W2092817296 @default.
• W3192170398 cites W2103441770 @default.
• W3192170398 cites W2106111071 @default.
• W3192170398 cites W2127159837 @default.
• W3192170398 cites W2128264186 @default.
• W3192170398 cites W2131473084 @default.
• W3192170398 cites W2133445196 @default.
• W3192170398 cites W2136957030 @default.
• W3192170398 cites W2145691034 @default.
• W3192170398 cites W2152207030 @default.
• W3192170398 cites W2166494052 @default.
• W3192170398 cites W2166672798 @default.
• W3192170398 cites W2171276551 @default.
• W3192170398 cites W2171678244 @default.
• W3192170398 cites W2274420474 @default.
• W3192170398 cites W2400661548 @default.
• W3192170398 cites W2408328645 @default.
• W3192170398 cites W2409483844 @default.
• W3192170398 cites W2525650629 @default.
• W3192170398 cites W2901175304 @default.
• W3192170398 cites W3162377453 @default.
• W3192170398 cites W39106355 @default.
• W3192170398 cites W4241047728 @default.
• W3192170398 doi "https://doi.org/10.1101/2021.08.09.455771" @default.
• W3192170398 hasPublicationYear "2021" @default.
• W3192170398 type Work @default.
• W3192170398 sameAs 3192170398 @default.
• W3192170398 citedByCount "0" @default.
• W3192170398 crossrefType "posted-content" @default.
• W3192170398 hasAuthorship W3192170398A5000032892 @default.
• W3192170398 hasAuthorship W3192170398A5019661133 @default.
• W3192170398 hasAuthorship W3192170398A5033878605 @default.
• W3192170398 hasAuthorship W3192170398A5036978602 @default.
• W3192170398 hasAuthorship W3192170398A5043184761 @default.
• W3192170398 hasAuthorship W3192170398A5045977099 @default.
• W3192170398 hasAuthorship W3192170398A5057473582 @default.
• W3192170398 hasAuthorship W3192170398A5071022972 @default.
• W3192170398 hasBestOaLocation W31921703981 @default.
• W3192170398 hasConcept C104317684 @default.
• W3192170398 hasConcept C141231307 @default.
• W3192170398 hasConcept C142724271 @default.
• W3192170398 hasConcept C159047783 @default.
• W3192170398 hasConcept C16154277 @default.
• W3192170398 hasConcept C2522874641 @default.
• W3192170398 hasConcept C2776914050 @default.
• W3192170398 hasConcept C2778116200 @default.
• W3192170398 hasConcept C2779134260 @default.
• W3192170398 hasConcept C3008058167 @default.
• W3192170398 hasConcept C524204448 @default.
• W3192170398 hasConcept C54355233 @default.
• W3192170398 hasConcept C71924100 @default.
• W3192170398 hasConcept C78458016 @default.
• W3192170398 hasConcept C86803240 @default.
• W3192170398 hasConceptScore W3192170398C104317684 @default.
• W3192170398 hasConceptScore W3192170398C141231307 @default.
• W3192170398 hasConceptScore W3192170398C142724271 @default.
• W3192170398 hasConceptScore W3192170398C159047783 @default.
• W3192170398 hasConceptScore W3192170398C16154277 @default.
• W3192170398 hasConceptScore W3192170398C2522874641 @default.
• W3192170398 hasConceptScore W3192170398C2776914050 @default.
• W3192170398 hasConceptScore W3192170398C2778116200 @default.
• W3192170398 hasConceptScore W3192170398C2779134260 @default.
• W3192170398 hasConceptScore W3192170398C3008058167 @default.

• next