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- W3192271892 abstract "Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments." @default.
- W3192271892 created "2021-08-16" @default.
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- W3192271892 date "2021-12-01" @default.
- W3192271892 modified "2023-10-03" @default.
- W3192271892 title "5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment" @default.
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- W3192271892 doi "https://doi.org/10.1016/j.carbpol.2021.118523" @default.
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