FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192275320> ?p ?o ?g. }

• W3192275320 abstract "Abstract Discovery of a biomarker for patients at high risk of progression to severe Coronavirus Disease 2019 (COVID-19) is critical for clinical management, particularly in areas of the world where widespread vaccine distribution and herd immunity have yet to be achieved. Herein, we characterize peripheral blood from 218 COVID-19 patients with flow cytometry and provide evidence that megakaryocytes are a target for infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We demonstrate a positive correlation between infected megakaryocytes expressing the protein calprotectin (also called S100A8/A9), a known marker of COVID-19 severity. Additionally, we show that infected, calprotectin expressing megakaryocytes are correlated with COVID-19 severity and are a prognostic indicator of 30-day clinical outcomes including respiratory failure, thrombotic events, acute kidney injury (AKI), ICU admission, and mechanical ventilation. These findings represent a novel SARS-CoV-2 infection target with significant clinical implications as a biomarker for clinical outcomes associated with severe COVID-19." @default.
• W3192275320 created "2021-08-16" @default.
• W3192275320 creator A5009021961 @default.
• W3192275320 creator A5009206760 @default.
• W3192275320 creator A5015182732 @default.
• W3192275320 creator A5015978856 @default.
• W3192275320 creator A5020733847 @default.
• W3192275320 creator A5025852667 @default.
• W3192275320 creator A5035278948 @default.
• W3192275320 creator A5041300675 @default.
• W3192275320 creator A5044981782 @default.
• W3192275320 creator A5056830824 @default.
• W3192275320 creator A5057111554 @default.
• W3192275320 creator A5058833186 @default.
• W3192275320 creator A5061978478 @default.
• W3192275320 creator A5068242196 @default.
• W3192275320 creator A5083537513 @default.
• W3192275320 creator A5083595886 @default.
• W3192275320 creator A5086121459 @default.
• W3192275320 creator A5090790767 @default.
• W3192275320 date "2021-08-07" @default.
• W3192275320 modified "2023-09-27" @default.
• W3192275320 title "Megakaryocytes are a Novel SARS-CoV-2 Infection Target and Risk Factor for Mortality and Multi-Organ Failure" @default.
• W3192275320 cites W2289353175 @default.
• W3192275320 cites W2488349538 @default.
• W3192275320 cites W3009625308 @default.
• W3192275320 cites W3027630905 @default.
• W3192275320 cites W3033997257 @default.
• W3192275320 cites W3036681929 @default.
• W3192275320 cites W3037229948 @default.
• W3192275320 cites W3047168254 @default.
• W3192275320 cites W3047880178 @default.
• W3192275320 cites W3085715897 @default.
• W3192275320 cites W3087377819 @default.
• W3192275320 cites W3088800697 @default.
• W3192275320 cites W3093899914 @default.
• W3192275320 cites W3126452618 @default.
• W3192275320 cites W3128961456 @default.
• W3192275320 doi "https://doi.org/10.1101/2021.08.05.21261552" @default.
• W3192275320 hasPublicationYear "2021" @default.
• W3192275320 type Work @default.
• W3192275320 sameAs 3192275320 @default.
• W3192275320 citedByCount "2" @default.
• W3192275320 countsByYear W31922753202022 @default.
• W3192275320 crossrefType "posted-content" @default.
• W3192275320 hasAuthorship W3192275320A5009021961 @default.
• W3192275320 hasAuthorship W3192275320A5009206760 @default.
• W3192275320 hasAuthorship W3192275320A5015182732 @default.
• W3192275320 hasAuthorship W3192275320A5015978856 @default.
• W3192275320 hasAuthorship W3192275320A5020733847 @default.
• W3192275320 hasAuthorship W3192275320A5025852667 @default.
• W3192275320 hasAuthorship W3192275320A5035278948 @default.
• W3192275320 hasAuthorship W3192275320A5041300675 @default.
• W3192275320 hasAuthorship W3192275320A5044981782 @default.
• W3192275320 hasAuthorship W3192275320A5056830824 @default.
• W3192275320 hasAuthorship W3192275320A5057111554 @default.
• W3192275320 hasAuthorship W3192275320A5058833186 @default.
• W3192275320 hasAuthorship W3192275320A5061978478 @default.
• W3192275320 hasAuthorship W3192275320A5068242196 @default.
• W3192275320 hasAuthorship W3192275320A5083537513 @default.
• W3192275320 hasAuthorship W3192275320A5083595886 @default.
• W3192275320 hasAuthorship W3192275320A5086121459 @default.
• W3192275320 hasAuthorship W3192275320A5090790767 @default.
• W3192275320 hasBestOaLocation W31922753201 @default.
• W3192275320 hasConcept C126322002 @default.
• W3192275320 hasConcept C203014093 @default.
• W3192275320 hasConcept C2776888751 @default.
• W3192275320 hasConcept C2776914184 @default.
• W3192275320 hasConcept C2777648638 @default.
• W3192275320 hasConcept C2778260677 @default.
• W3192275320 hasConcept C2778292693 @default.
• W3192275320 hasConcept C2778557267 @default.
• W3192275320 hasConcept C2779134260 @default.
• W3192275320 hasConcept C2781197716 @default.
• W3192275320 hasConcept C30036603 @default.
• W3192275320 hasConcept C3008058167 @default.
• W3192275320 hasConcept C524204448 @default.
• W3192275320 hasConcept C55493867 @default.
• W3192275320 hasConcept C71924100 @default.
• W3192275320 hasConcept C86803240 @default.
• W3192275320 hasConceptScore W3192275320C126322002 @default.
• W3192275320 hasConceptScore W3192275320C203014093 @default.
• W3192275320 hasConceptScore W3192275320C2776888751 @default.
• W3192275320 hasConceptScore W3192275320C2776914184 @default.
• W3192275320 hasConceptScore W3192275320C2777648638 @default.
• W3192275320 hasConceptScore W3192275320C2778260677 @default.
• W3192275320 hasConceptScore W3192275320C2778292693 @default.
• W3192275320 hasConceptScore W3192275320C2778557267 @default.
• W3192275320 hasConceptScore W3192275320C2779134260 @default.
• W3192275320 hasConceptScore W3192275320C2781197716 @default.
• W3192275320 hasConceptScore W3192275320C30036603 @default.
• W3192275320 hasConceptScore W3192275320C3008058167 @default.
• W3192275320 hasConceptScore W3192275320C524204448 @default.
• W3192275320 hasConceptScore W3192275320C55493867 @default.
• W3192275320 hasConceptScore W3192275320C71924100 @default.
• W3192275320 hasConceptScore W3192275320C86803240 @default.
• W3192275320 hasLocation W31922753201 @default.
• W3192275320 hasOpenAccess W3192275320 @default.
• W3192275320 hasPrimaryLocation W31922753201 @default.
• W3192275320 hasRelatedWork W2528801841 @default.

• next