FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192282135> ?p ?o ?g. }

• W3192282135 endingPage "10213" @default.
• W3192282135 startingPage "10200" @default.
• W3192282135 abstract "Self-emulsifying drug-delivery systems (SEDDS) have been extensively shown to increase oral absorption of solvation-limited compounds. However, there has been little clinical and commercial use of these formulations, in large part because the demonstrated advantages of SEDDS have been outweighed by our inability to precisely predict drug absorption from SEDDS using current in vitro assays. To overcome this limitation and increase the biological relevancy of in vitro assays, an absorption function can be incorporated using biomimetic membranes. However, the effects that SEDDS have on the integrity of a biomimetic membrane are not known. In this study, a quartz crystal microbalance with dissipation monitoring and total internal reflection fluorescence microscopy were employed as complementary methods to in vitro lipolysis-permeation assays to characterize the interaction of various actively digested SEDDS with a liquescent artificial membrane comprising lecithin in dodecane (LiDo). Observations from surface analysis showed that interactions between the digesting SEDDS and LiDo membrane coincided with inflection points in the digestion profiles. Importantly, no indications of membrane damage could be observed, which was supported by flux profiles of the lipophilic model drug felodipine (FEL) and impermeable marker Lucifer yellow on the basal side of the membrane. There was a correlation between the digestion kinetics of the SEDDS and the flux of FEL, but no clear correlation between solubilization and absorption profiles. Membrane interactions were dependent on the composition of lipids within each SEDDS, with the more digestible lipids leading to more pronounced interactions, but in all cases, the integrity of the membrane was maintained. These insights demonstrate that LiDo membranes are compatible with in vitro lipolysis assays for improving predictions of drug absorption from lipid-based formulations." @default.
• W3192282135 created "2021-08-16" @default.
• W3192282135 creator A5049446489 @default.
• W3192282135 creator A5050086795 @default.
• W3192282135 creator A5064646804 @default.
• W3192282135 creator A5071908671 @default.
• W3192282135 date "2021-08-11" @default.
• W3192282135 modified "2023-10-18" @default.
• W3192282135 title "Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine" @default.
• W3192282135 cites W1832477011 @default.
• W3192282135 cites W1970004609 @default.
• W3192282135 cites W1983076714 @default.
• W3192282135 cites W1995529190 @default.
• W3192282135 cites W2005101090 @default.
• W3192282135 cites W2005844949 @default.
• W3192282135 cites W2012536715 @default.
• W3192282135 cites W2025187639 @default.
• W3192282135 cites W2032716251 @default.
• W3192282135 cites W2042127972 @default.
• W3192282135 cites W2050893597 @default.
• W3192282135 cites W2051311750 @default.
• W3192282135 cites W2056847422 @default.
• W3192282135 cites W2056995570 @default.
• W3192282135 cites W2066927092 @default.
• W3192282135 cites W2067519806 @default.
• W3192282135 cites W2088720601 @default.
• W3192282135 cites W2104016565 @default.
• W3192282135 cites W2111444379 @default.
• W3192282135 cites W2129258640 @default.
• W3192282135 cites W2131294006 @default.
• W3192282135 cites W2144262303 @default.
• W3192282135 cites W2172610030 @default.
• W3192282135 cites W2313724273 @default.
• W3192282135 cites W2339540179 @default.
• W3192282135 cites W2339649458 @default.
• W3192282135 cites W2519901267 @default.
• W3192282135 cites W2550985100 @default.
• W3192282135 cites W2588926362 @default.
• W3192282135 cites W2739425417 @default.
• W3192282135 cites W2747171438 @default.
• W3192282135 cites W2751824458 @default.
• W3192282135 cites W2810751157 @default.
• W3192282135 cites W2884477538 @default.
• W3192282135 cites W2896640429 @default.
• W3192282135 cites W2904301117 @default.
• W3192282135 cites W2909432337 @default.
• W3192282135 cites W2914191902 @default.
• W3192282135 cites W2943263610 @default.
• W3192282135 cites W3003265699 @default.
• W3192282135 cites W3012441164 @default.
• W3192282135 cites W3028518620 @default.
• W3192282135 cites W3032974176 @default.
• W3192282135 cites W3036266787 @default.
• W3192282135 cites W3048351201 @default.
• W3192282135 cites W3085546290 @default.
• W3192282135 cites W3087063757 @default.
• W3192282135 cites W3095226898 @default.
• W3192282135 cites W3108379734 @default.
• W3192282135 cites W3122747340 @default.
• W3192282135 cites W3143361031 @default.
• W3192282135 doi "https://doi.org/10.1021/acs.langmuir.1c01689" @default.
• W3192282135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8388123" @default.
• W3192282135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34379976" @default.
• W3192282135 hasPublicationYear "2021" @default.
• W3192282135 type Work @default.
• W3192282135 sameAs 3192282135 @default.
• W3192282135 citedByCount "5" @default.
• W3192282135 countsByYear W31922821352022 @default.
• W3192282135 countsByYear W31922821352023 @default.
• W3192282135 crossrefType "journal-article" @default.
• W3192282135 hasAuthorship W3192282135A5049446489 @default.
• W3192282135 hasAuthorship W3192282135A5050086795 @default.
• W3192282135 hasAuthorship W3192282135A5064646804 @default.
• W3192282135 hasAuthorship W3192282135A5071908671 @default.
• W3192282135 hasBestOaLocation W31922821351 @default.
• W3192282135 hasConcept C125287762 @default.
• W3192282135 hasConcept C125501631 @default.
• W3192282135 hasConcept C12554922 @default.
• W3192282135 hasConcept C159985019 @default.
• W3192282135 hasConcept C178790620 @default.
• W3192282135 hasConcept C185592680 @default.
• W3192282135 hasConcept C192562407 @default.
• W3192282135 hasConcept C2779820397 @default.
• W3192282135 hasConcept C39944091 @default.
• W3192282135 hasConcept C41625074 @default.
• W3192282135 hasConcept C43617362 @default.
• W3192282135 hasConcept C50670333 @default.
• W3192282135 hasConcept C55493867 @default.
• W3192282135 hasConcept C86803240 @default.
• W3192282135 hasConceptScore W3192282135C125287762 @default.
• W3192282135 hasConceptScore W3192282135C125501631 @default.
• W3192282135 hasConceptScore W3192282135C12554922 @default.
• W3192282135 hasConceptScore W3192282135C159985019 @default.
• W3192282135 hasConceptScore W3192282135C178790620 @default.
• W3192282135 hasConceptScore W3192282135C185592680 @default.
• W3192282135 hasConceptScore W3192282135C192562407 @default.
• W3192282135 hasConceptScore W3192282135C2779820397 @default.
• W3192282135 hasConceptScore W3192282135C39944091 @default.

• next