FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192296002> ?p ?o ?g. }

• W3192296002 endingPage "800" @default.
• W3192296002 startingPage "789" @default.
• W3192296002 abstract "In the past, protease inhibitors (PIs) and the reverse transcriptase inhibitor abacavir were identified increasing the risk for thromboembolic complications and cardiovascular events (CVE) of HIV infected patients taking a combination antiretroviral therapy (cART). Results of the previous HIV-PLA I-study lead to the assumption that platelet activation could play a substantial role in increasing CVE risks.The open label, monocentric HIV-PLA II-study investigated HIV-1-infected, therapy-naïve adults (n=45) starting with cART, consisting either of boosted PI (atazanavir, n= 6, darunavir, n=11), NNRTI (efavirenz, n=14) or integrase inhibitor (raltegravir, n=14), each plus tenofovir/emtricitabine co-medication. Main exclusion criteria were tobacco smoking, the intake of NSAIDs or abacavir or past CVE. Platelet adhesive molecule p-selectin (CD62P) and FITC anti-human Integrin α-IIb/Integrin β-3 (CD41/CD61) antibody (PAC-1) binding, monocyte CD11b/monocyte-associated CD41 expression and the endogenous thrombin potential (ETP) were assessed ex vivo-in vitro at baseline, weeks 4, 12 and 24. Therapy regimens were blinded to the investigators for laboratory and statistical analyses.CD11b and ETP showed no significant changes or differences between all study groups. In contrast, the mean + SD mean fluorescence units (MFI) of CD62P and PAC-1 increased significantly in patients taking PI, indicating an enhanced potential for thrombocyte activation and aggregation.CD62P expression, detecting the ɑ-platelet degranulation of pro-inflammatory and pro-thrombotic factors and adhesive proteins, and PAC-1 expression, representing a marker for conformation changes of the GIIb/IIIa receptor, increased significantly in patients taking HIV protease inhibitors. The findings of this study revealed a yet unknown pathway of platelet activation, possibly contributing to the increased risk for CVE under HIV protease inhibitor containing cART.DRKS00000288." @default.
• W3192296002 created "2021-08-16" @default.
• W3192296002 creator A5001079546 @default.
• W3192296002 creator A5005727195 @default.
• W3192296002 creator A5008932748 @default.
• W3192296002 creator A5013296898 @default.
• W3192296002 creator A5030943230 @default.
• W3192296002 creator A5032953192 @default.
• W3192296002 creator A5042806386 @default.
• W3192296002 creator A5047626680 @default.
• W3192296002 creator A5070006495 @default.
• W3192296002 date "2021-08-01" @default.
• W3192296002 modified "2023-09-26" @default.
• W3192296002 title "Evaluation of Platelet Activation by HIV Protease Inhibitors – The HIV-PLA II Study" @default.
• W3192296002 cites W1167402255 @default.
• W3192296002 cites W131528519 @default.
• W3192296002 cites W1484320290 @default.
• W3192296002 cites W1584517767 @default.
• W3192296002 cites W1826819713 @default.
• W3192296002 cites W1987813580 @default.
• W3192296002 cites W1989947634 @default.
• W3192296002 cites W1993316129 @default.
• W3192296002 cites W2000281754 @default.
• W3192296002 cites W2016934195 @default.
• W3192296002 cites W2022016068 @default.
• W3192296002 cites W2022686380 @default.
• W3192296002 cites W2036594368 @default.
• W3192296002 cites W2037619924 @default.
• W3192296002 cites W2038132408 @default.
• W3192296002 cites W2039794360 @default.
• W3192296002 cites W2040571934 @default.
• W3192296002 cites W2044189614 @default.
• W3192296002 cites W2056591375 @default.
• W3192296002 cites W2060090185 @default.
• W3192296002 cites W2066933846 @default.
• W3192296002 cites W2067288493 @default.
• W3192296002 cites W2074631336 @default.
• W3192296002 cites W2082264161 @default.
• W3192296002 cites W2116628201 @default.
• W3192296002 cites W2123354892 @default.
• W3192296002 cites W2126258404 @default.
• W3192296002 cites W2141449346 @default.
• W3192296002 cites W2143986922 @default.
• W3192296002 cites W2153136696 @default.
• W3192296002 cites W2153335144 @default.
• W3192296002 cites W2155816106 @default.
• W3192296002 cites W2157138119 @default.
• W3192296002 cites W2164696237 @default.
• W3192296002 cites W2166332290 @default.
• W3192296002 cites W2327262339 @default.
• W3192296002 cites W2802578844 @default.
• W3192296002 cites W4253501181 @default.
• W3192296002 cites W73759871 @default.
• W3192296002 cites W87842338 @default.
• W3192296002 cites W1969250799 @default.
• W3192296002 cites W2057192711 @default.
• W3192296002 doi "https://doi.org/10.2147/hiv.s262282" @default.
• W3192296002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8354741" @default.
• W3192296002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34393518" @default.
• W3192296002 hasPublicationYear "2021" @default.
• W3192296002 type Work @default.
• W3192296002 sameAs 3192296002 @default.
• W3192296002 citedByCount "1" @default.
• W3192296002 countsByYear W31922960022023 @default.
• W3192296002 crossrefType "journal-article" @default.
• W3192296002 hasAuthorship W3192296002A5001079546 @default.
• W3192296002 hasAuthorship W3192296002A5005727195 @default.
• W3192296002 hasAuthorship W3192296002A5008932748 @default.
• W3192296002 hasAuthorship W3192296002A5013296898 @default.
• W3192296002 hasAuthorship W3192296002A5030943230 @default.
• W3192296002 hasAuthorship W3192296002A5032953192 @default.
• W3192296002 hasAuthorship W3192296002A5042806386 @default.
• W3192296002 hasAuthorship W3192296002A5047626680 @default.
• W3192296002 hasAuthorship W3192296002A5070006495 @default.
• W3192296002 hasBestOaLocation W31922960021 @default.
• W3192296002 hasConcept C126322002 @default.
• W3192296002 hasConcept C142462285 @default.
• W3192296002 hasConcept C185592680 @default.
• W3192296002 hasConcept C203014093 @default.
• W3192296002 hasConcept C2778414717 @default.
• W3192296002 hasConcept C2779182219 @default.
• W3192296002 hasConcept C2779465607 @default.
• W3192296002 hasConcept C2779778239 @default.
• W3192296002 hasConcept C2780404665 @default.
• W3192296002 hasConcept C2781432083 @default.
• W3192296002 hasConcept C2993143319 @default.
• W3192296002 hasConcept C3013748606 @default.
• W3192296002 hasConcept C3018697912 @default.
• W3192296002 hasConcept C71924100 @default.
• W3192296002 hasConcept C89560881 @default.
• W3192296002 hasConcept C98274493 @default.
• W3192296002 hasConceptScore W3192296002C126322002 @default.
• W3192296002 hasConceptScore W3192296002C142462285 @default.
• W3192296002 hasConceptScore W3192296002C185592680 @default.
• W3192296002 hasConceptScore W3192296002C203014093 @default.
• W3192296002 hasConceptScore W3192296002C2778414717 @default.
• W3192296002 hasConceptScore W3192296002C2779182219 @default.
• W3192296002 hasConceptScore W3192296002C2779465607 @default.

• next