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• W3192319650 endingPage "105040" @default.
• W3192319650 startingPage "105040" @default.
• W3192319650 abstract "Ovarian hormone deprivation is associated with mood disorders, such as depression, and estradiol therapy is significantly more effective than placebos in treating major depression associated with menopause onset. However, the effect of estradiol on neuronal plasticity and its mechanisms remain to be further elucidated. In this study, behavioral assessments were used to examine the antidepressant effect of estradiol in ovariectomized (OVX) B6.Cg-TgN (Thy-YFP-H)-2Jrs transgenic mice on chronic restraint stress (CRS)-induced dendrite and dendritic spine loss; Yellow fluorescent protein (YFP) is characteristically expressed in excitatory neurons in transgenic mice, and its three-dimensional images were used to evaluate the effect of estradiol on the density of different types of dendritic spines. Quantification and distribution of cofilin1 and p-cofilin1 were determined by qPCR, Western blots, and immunohistochemistry, respectively. The results revealed that treatment with estradiol or clomipramine significantly improved depression-like behaviors. Estradiol treatment also significantly upregulated the dendritic density in all areas examined and increased the density of filopodia-type, thin-type and mushroom-type spines in the hippocampal CA1 and elevated the thin-type and mushroom-type spine density in the PFC. Consistent with these changes, estradiol treatment significantly increased the density of p-cofilin1 immunopositive dendritic spines. Thus, these data reveal a possible estradiol antidepressant mechanism, in that estradiol promoted the phosphorylation of cofilin1 and reduced the loss of dendrites and dendritic spines, which of these dendritic spines include not only immature spines such as filopodia-type, but also mature spines such as mushroom-type, and attenuated the depression-like behavior." @default.
• W3192319650 created "2021-08-16" @default.
• W3192319650 creator A5002042063 @default.
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• W3192319650 creator A5091518078 @default.
• W3192319650 date "2021-09-01" @default.
• W3192319650 modified "2023-10-03" @default.
• W3192319650 title "Estradiol attenuates chronic restraint stress-induced dendrite and dendritic spine loss and cofilin1 activation in ovariectomized mice" @default.
• W3192319650 cites W1510981253 @default.
• W3192319650 cites W1640813462 @default.
• W3192319650 cites W1962613158 @default.
• W3192319650 cites W1969680120 @default.
• W3192319650 cites W1976447270 @default.
• W3192319650 cites W1977444106 @default.
• W3192319650 cites W1978891587 @default.
• W3192319650 cites W1980574091 @default.
• W3192319650 cites W1982839897 @default.
• W3192319650 cites W1986586797 @default.
• W3192319650 cites W1987123219 @default.
• W3192319650 cites W1987389041 @default.
• W3192319650 cites W1987528796 @default.
• W3192319650 cites W1988281595 @default.
• W3192319650 cites W1993176591 @default.
• W3192319650 cites W1996009982 @default.
• W3192319650 cites W1996300933 @default.
• W3192319650 cites W2002639930 @default.
• W3192319650 cites W2004069543 @default.
• W3192319650 cites W2004366364 @default.
• W3192319650 cites W2005459396 @default.
• W3192319650 cites W2011209444 @default.
• W3192319650 cites W2018643157 @default.
• W3192319650 cites W2021613777 @default.
• W3192319650 cites W2022057141 @default.
• W3192319650 cites W2029992524 @default.
• W3192319650 cites W2032679251 @default.
• W3192319650 cites W2032679733 @default.
• W3192319650 cites W2032877790 @default.
• W3192319650 cites W2034891565 @default.
• W3192319650 cites W2037111632 @default.
• W3192319650 cites W2037557484 @default.
• W3192319650 cites W2040347331 @default.
• W3192319650 cites W2040801339 @default.
• W3192319650 cites W2042075182 @default.
• W3192319650 cites W2048089018 @default.
• W3192319650 cites W2048822470 @default.
• W3192319650 cites W2049163404 @default.
• W3192319650 cites W2050836998 @default.
• W3192319650 cites W2053472601 @default.
• W3192319650 cites W2056366478 @default.
• W3192319650 cites W2062248891 @default.
• W3192319650 cites W2063997888 @default.
• W3192319650 cites W2067912379 @default.
• W3192319650 cites W2068292117 @default.
• W3192319650 cites W2070017293 @default.
• W3192319650 cites W2072173628 @default.
• W3192319650 cites W2074756898 @default.
• W3192319650 cites W2075708698 @default.
• W3192319650 cites W2077099677 @default.
• W3192319650 cites W2078229830 @default.
• W3192319650 cites W2082024168 @default.
• W3192319650 cites W2089299823 @default.
• W3192319650 cites W2091612053 @default.
• W3192319650 cites W2095086331 @default.
• W3192319650 cites W2098282522 @default.
• W3192319650 cites W2099782016 @default.
• W3192319650 cites W2101473364 @default.
• W3192319650 cites W2102368994 @default.
• W3192319650 cites W2102889645 @default.
• W3192319650 cites W2104463303 @default.
• W3192319650 cites W2106041766 @default.
• W3192319650 cites W2106623141 @default.
• W3192319650 cites W2107611011 @default.
• W3192319650 cites W2110887671 @default.
• W3192319650 cites W2111441108 @default.
• W3192319650 cites W2113786093 @default.
• W3192319650 cites W2114129553 @default.
• W3192319650 cites W2116130782 @default.
• W3192319650 cites W2119570806 @default.
• W3192319650 cites W2124646091 @default.
• W3192319650 cites W2124683806 @default.
• W3192319650 cites W2126496496 @default.
• W3192319650 cites W2127810309 @default.
• W3192319650 cites W2128270206 @default.
• W3192319650 cites W2136452679 @default.
• W3192319650 cites W2142604492 @default.
• W3192319650 cites W2157504436 @default.
• W3192319650 cites W2158846562 @default.
• W3192319650 cites W2160222704 @default.
• W3192319650 cites W2165460241 @default.
• W3192319650 cites W2167051392 @default.

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