FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192385481> ?p ?o ?g. }

• W3192385481 endingPage "11690" @default.
• W3192385481 startingPage "11676" @default.
• W3192385481 abstract "Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype generally associated with younger women. Due to the lack of suitable drugable targets in TNBC, the microRNAs are considered as a better hope as therapeutic agents for the management of the disease. In this study, we identified differentially expressed miRNAs (DEMs) and associated hub genes in TNBC microarray data (GSE38167, GSE60714, and GSE10833) using bioinformatics tools. The identified miRNAs and genes were validated in the TNBC cell line model (MDA-MB-231) compared with the normal breast cells (MCF-10A) using the qRT-PCR technique. False-positive DEMs were avoided by comparing the DEMs profile of TNBC and triple positive breast cancer (TPBC) cell line model (BT474) compared with the MCF-10A cells data. In addition, we studied the effect of anticancer phytochemicals on the differential expression of miRNAs and genes in MDA-MB-231 cells. Furthermore, target predictions, functional enrichment and KEGG pathway analysis, mutation and copy number alterations, and overall survival analysis of DEMs in TNBC sample was investigated using standard computational tools. The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC. DEMs showed significant association with the Wnt, ErbB, PI3-Akt and cAMP signaling pathways having clinical implications in TNBC tumorigenesis. The DEMs and hub genes (HOXC6 and ACVR2B) showed survival disadvantages in TNBC patients. In summary, the identified miRNAs and hub genes show important implications in TNBC tumorigenesis and patient survival. We recommend further experimental studies on pathophysiological mechanism of the identified miRNAs and hub genes in TNBC.Communicated by Ramaswamy H. Sarma." @default.
• W3192385481 created "2021-08-16" @default.
• W3192385481 creator A5027090470 @default.
• W3192385481 creator A5042567674 @default.
• W3192385481 creator A5049247515 @default.
• W3192385481 creator A5050958863 @default.
• W3192385481 creator A5059637049 @default.
• W3192385481 creator A5080237697 @default.
• W3192385481 date "2021-08-13" @default.
• W3192385481 modified "2023-10-16" @default.
• W3192385481 title "Identification of miRNAs and related hub genes associated with the triple negative breast cancer using integrated bioinformatics analysis and <i>in vitro</i> approach" @default.
• W3192385481 cites W1578104218 @default.
• W3192385481 cites W1587423226 @default.
• W3192385481 cites W1903822134 @default.
• W3192385481 cites W1966133006 @default.
• W3192385481 cites W1982475981 @default.
• W3192385481 cites W1987405718 @default.
• W3192385481 cites W2003816656 @default.
• W3192385481 cites W2004242961 @default.
• W3192385481 cites W2025169368 @default.
• W3192385481 cites W2032125405 @default.
• W3192385481 cites W2036647671 @default.
• W3192385481 cites W2056048839 @default.
• W3192385481 cites W2074244952 @default.
• W3192385481 cites W2084770914 @default.
• W3192385481 cites W2094253263 @default.
• W3192385481 cites W2094720383 @default.
• W3192385481 cites W2103912979 @default.
• W3192385481 cites W2114843025 @default.
• W3192385481 cites W2118258530 @default.
• W3192385481 cites W2119693744 @default.
• W3192385481 cites W2130642180 @default.
• W3192385481 cites W2133465414 @default.
• W3192385481 cites W2147304472 @default.
• W3192385481 cites W2149594317 @default.
• W3192385481 cites W2158217645 @default.
• W3192385481 cites W2159675211 @default.
• W3192385481 cites W2161956519 @default.
• W3192385481 cites W2163169932 @default.
• W3192385481 cites W2204493619 @default.
• W3192385481 cites W2262087088 @default.
• W3192385481 cites W2531294657 @default.
• W3192385481 cites W2542646006 @default.
• W3192385481 cites W2570618306 @default.
• W3192385481 cites W2607129810 @default.
• W3192385481 cites W2740518645 @default.
• W3192385481 cites W2746741726 @default.
• W3192385481 cites W2751974605 @default.
• W3192385481 cites W2761653766 @default.
• W3192385481 cites W2768123142 @default.
• W3192385481 cites W2802706983 @default.
• W3192385481 cites W2807169763 @default.
• W3192385481 cites W2895999225 @default.
• W3192385481 cites W2908762777 @default.
• W3192385481 cites W2969263349 @default.
• W3192385481 cites W2969289454 @default.
• W3192385481 cites W2969679037 @default.
• W3192385481 cites W2971652399 @default.
• W3192385481 cites W2981531797 @default.
• W3192385481 cites W2982477353 @default.
• W3192385481 cites W3008865125 @default.
• W3192385481 cites W3010449962 @default.
• W3192385481 cites W3045126382 @default.
• W3192385481 cites W3046952295 @default.
• W3192385481 cites W3092872568 @default.
• W3192385481 cites W3136831941 @default.
• W3192385481 cites W3177065918 @default.
• W3192385481 doi "https://doi.org/10.1080/07391102.2021.1961869" @default.
• W3192385481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34387138" @default.
• W3192385481 hasPublicationYear "2021" @default.
• W3192385481 type Work @default.
• W3192385481 sameAs 3192385481 @default.
• W3192385481 citedByCount "7" @default.
• W3192385481 countsByYear W31923854812021 @default.
• W3192385481 countsByYear W31923854812022 @default.
• W3192385481 countsByYear W31923854812023 @default.
• W3192385481 crossrefType "journal-article" @default.
• W3192385481 hasAuthorship W3192385481A5027090470 @default.
• W3192385481 hasAuthorship W3192385481A5042567674 @default.
• W3192385481 hasAuthorship W3192385481A5049247515 @default.
• W3192385481 hasAuthorship W3192385481A5050958863 @default.
• W3192385481 hasAuthorship W3192385481A5059637049 @default.
• W3192385481 hasAuthorship W3192385481A5080237697 @default.
• W3192385481 hasConcept C104317684 @default.
• W3192385481 hasConcept C121608353 @default.
• W3192385481 hasConcept C137620995 @default.
• W3192385481 hasConcept C145059251 @default.
• W3192385481 hasConcept C150194340 @default.
• W3192385481 hasConcept C152724338 @default.
• W3192385481 hasConcept C162317418 @default.
• W3192385481 hasConcept C2779251935 @default.
• W3192385481 hasConcept C2780110267 @default.
• W3192385481 hasConcept C502942594 @default.
• W3192385481 hasConcept C530470458 @default.
• W3192385481 hasConcept C54355233 @default.
• W3192385481 hasConcept C555283112 @default.
• W3192385481 hasConcept C60644358 @default.
• W3192385481 hasConcept C70721500 @default.

• next