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- W3192412225 abstract "Growth factors (GFs) and cytokines have a great potential in regenerative medicine. However, clinical translation of these biologics has been modest. The main challenges include side effects and cost-efficiency issues which are related to the high doses required to reach therapeutic benefits. Therefore, to overcome these drawbacks, better delivery strategies need to be developed. A promising strategy is to engineer biologics to bind extracellular matrix (ECM) components. Here, we engineered platelet-derived growth factor-BB and interleukin-1 (IL-1) receptor antagonist to have a super-affinity for the ECM. Moreover, we explored the impact of IL-1 signalling on GF regenerative effects in mouse models." @default.
- W3192412225 created "2021-08-16" @default.
- W3192412225 creator A5017985029 @default.
- W3192412225 date "2021-08-02" @default.
- W3192412225 modified "2023-09-23" @default.
- W3192412225 title "Engineering interleukin-1 receptor antagonist and platelet-derived growth factor-BB for regenerative medicine applications" @default.
- W3192412225 doi "https://doi.org/10.26180/15088887.v1" @default.
- W3192412225 hasPublicationYear "2021" @default.
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