FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192488596> ?p ?o ?g. }

• W3192488596 endingPage "6914" @default.
• W3192488596 startingPage "6902" @default.
• W3192488596 abstract "Misfolding and the subsequent self-assembly of amyloid-β protein (Aβ) is very important in the occurrence of Alzheimer's disease (AD). Thus, inhibition of Aβ aggregation is currently an effective method to alleviate and treat AD. Herein, a carboxylated single-walled carbon nanotube (SWCNT-COOH) was rationally designed based on the hydrophobic binding-electrostatic repulsion (HyBER) mechanism. The inhibitory effect of SWCNT-COOH on Aβ fibrillogenesis was first studied. Based on the results of thioflavin T fluorescence and atomic force microscopy imaging assays, it was shown that SWCNT-COOH can not only effectively inhibit Aβ aggregation, but also depolymerize the mature fibrils of Aβ. In addition, its inhibitory action will be affected by the content of carboxyl groups. Moreover, the influence of SWCNT-COOH on cytotoxicity induced by Aβ was investigated by the MTT method. It was found that SWCNT-COOH can produce an anti-Aβ neuroprotective effect in vitro. Molecular dynamics simulations showed that SWCNT-COOH significantly destroyed the overall and internal structural stability of an Aβ40 trimer. Moreover, SWCNT-COOH interacted strongly with the N-terminal region, turn region and C-terminal region of the Aβ40 trimer via hydrogen bonds, salt bridges and π-π interactions, which triggered a large structural disturbance of the Aβ40 trimer, reduced the β-sheet content of the Aβ40 trimer and led to more disorder in these regions. All the above data not only reveal the suppressive effect of SWCNT-COOH on Aβ aggregation, but also reveal its inhibitory mechanism, which provides a useful clue to exploit anti-Aβ drugs in the future." @default.
• W3192488596 created "2021-08-16" @default.
• W3192488596 creator A5004741381 @default.
• W3192488596 creator A5016599418 @default.
• W3192488596 creator A5027475930 @default.
• W3192488596 creator A5031084065 @default.
• W3192488596 creator A5046732096 @default.
• W3192488596 creator A5047566541 @default.
• W3192488596 creator A5049262591 @default.
• W3192488596 creator A5060741317 @default.
• W3192488596 creator A5070049628 @default.
• W3192488596 date "2021-01-01" @default.
• W3192488596 modified "2023-10-10" @default.
• W3192488596 title "Design of carboxylated single-walled carbon nanotubes as highly efficient inhibitors against Aβ40 fibrillation based on the HyBER mechanism" @default.
• W3192488596 cites W1607136952 @default.
• W3192488596 cites W1928822904 @default.
• W3192488596 cites W1966501382 @default.
• W3192488596 cites W1968575670 @default.
• W3192488596 cites W1970587959 @default.
• W3192488596 cites W1971800836 @default.
• W3192488596 cites W1973134139 @default.
• W3192488596 cites W1987327052 @default.
• W3192488596 cites W1991659188 @default.
• W3192488596 cites W1998401862 @default.
• W3192488596 cites W2001148193 @default.
• W3192488596 cites W2005626048 @default.
• W3192488596 cites W2008708467 @default.
• W3192488596 cites W2011934320 @default.
• W3192488596 cites W2015640782 @default.
• W3192488596 cites W2029667189 @default.
• W3192488596 cites W2032022232 @default.
• W3192488596 cites W2035687084 @default.
• W3192488596 cites W2040039808 @default.
• W3192488596 cites W2045538379 @default.
• W3192488596 cites W2048940684 @default.
• W3192488596 cites W2056947115 @default.
• W3192488596 cites W2059013803 @default.
• W3192488596 cites W2065552081 @default.
• W3192488596 cites W2076213601 @default.
• W3192488596 cites W2079932486 @default.
• W3192488596 cites W2081678091 @default.
• W3192488596 cites W2081855136 @default.
• W3192488596 cites W2082337721 @default.
• W3192488596 cites W2098350532 @default.
• W3192488596 cites W2103440561 @default.
• W3192488596 cites W2108880064 @default.
• W3192488596 cites W2109386523 @default.
• W3192488596 cites W2119322608 @default.
• W3192488596 cites W2128124856 @default.
• W3192488596 cites W2140086663 @default.
• W3192488596 cites W2156128654 @default.
• W3192488596 cites W2157067671 @default.
• W3192488596 cites W2160544821 @default.
• W3192488596 cites W2166294424 @default.
• W3192488596 cites W2171663231 @default.
• W3192488596 cites W2287742623 @default.
• W3192488596 cites W2321720205 @default.
• W3192488596 cites W2327783954 @default.
• W3192488596 cites W2329336071 @default.
• W3192488596 cites W2333974835 @default.
• W3192488596 cites W2420659973 @default.
• W3192488596 cites W2476740982 @default.
• W3192488596 cites W2491310271 @default.
• W3192488596 cites W2538837691 @default.
• W3192488596 cites W2556389549 @default.
• W3192488596 cites W2563611748 @default.
• W3192488596 cites W2586046732 @default.
• W3192488596 cites W2726384187 @default.
• W3192488596 cites W2758885111 @default.
• W3192488596 cites W2763470548 @default.
• W3192488596 cites W2787358449 @default.
• W3192488596 cites W2846468914 @default.
• W3192488596 cites W2888299538 @default.
• W3192488596 cites W2897779578 @default.
• W3192488596 cites W2904074957 @default.
• W3192488596 cites W2914371025 @default.
• W3192488596 cites W2938173132 @default.
• W3192488596 cites W2943954503 @default.
• W3192488596 cites W2944679192 @default.
• W3192488596 cites W2948022003 @default.
• W3192488596 cites W2979137752 @default.
• W3192488596 cites W3029064834 @default.
• W3192488596 cites W3030727115 @default.
• W3192488596 cites W3080804286 @default.
• W3192488596 cites W3081059887 @default.
• W3192488596 cites W3113078272 @default.
• W3192488596 cites W3132372091 @default.
• W3192488596 cites W3156313548 @default.
• W3192488596 doi "https://doi.org/10.1039/d1tb00920f" @default.
• W3192488596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34612337" @default.
• W3192488596 hasPublicationYear "2021" @default.
• W3192488596 type Work @default.
• W3192488596 sameAs 3192488596 @default.
• W3192488596 citedByCount "11" @default.
• W3192488596 countsByYear W31924885962021 @default.
• W3192488596 countsByYear W31924885962022 @default.
• W3192488596 countsByYear W31924885962023 @default.
• W3192488596 crossrefType "journal-article" @default.

• next