FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192592389> ?p ?o ?g. }

• W3192592389 endingPage "8189" @default.
• W3192592389 startingPage "8189" @default.
• W3192592389 abstract "Ca2+-dependent gene regulation controls several functions to determine the fate of the cells. Proteins of the nuclear factor of activated T-cells (NFAT) family are Ca2+ sensitive transcription factors that control the cell growth, proliferation and insulin secretion in β-cells. Translocation of NFAT proteins to the nucleus occurs in a sequence of events that starts with activating calmodulin-dependent phosphatase calcineurin in a Ca2+-dependent manner, which dephosphorylates the NFAT proteins and leads to their translocation to the nucleus. Here, we examined the role of IP3-generating agonists and near-UV light in the induction of NFATc3 migration to the nucleus in the pancreatic β-cell line INS-1. Our results show that IP3 generation yields cytosolic Ca2+ rise and NFATc3 translocation. Moreover, near-UV light exposure generates reactive oxygen species (ROS), resulting in cytosolic Ca2+ spiking via the L-type Ca2+ channel and triggers NFATc3 translocation to the nucleus. Using the mitochondria as a Ca2+ buffering tool, we showed that ROS-induced cytosolic Ca2+ spiking, not the ROS themselves, was the triggering mechanism of nuclear import of NFATc3. Collectively, this study reveals the mechanism of near-UV light induced NFATc3 migration." @default.
• W3192592389 created "2021-08-16" @default.
• W3192592389 creator A5023552718 @default.
• W3192592389 creator A5040249032 @default.
• W3192592389 creator A5053111848 @default.
• W3192592389 creator A5063538471 @default.
• W3192592389 creator A5065993592 @default.
• W3192592389 creator A5066165238 @default.
• W3192592389 creator A5076104933 @default.
• W3192592389 creator A5078083544 @default.
• W3192592389 creator A5086127651 @default.
• W3192592389 date "2021-07-30" @default.
• W3192592389 modified "2023-10-17" @default.
• W3192592389 title "Near-UV Light Induced ROS Production Initiates Spatial Ca2+ Spiking to Fire NFATc3 Translocation" @default.
• W3192592389 cites W1573987088 @default.
• W3192592389 cites W2004466285 @default.
• W3192592389 cites W2006756372 @default.
• W3192592389 cites W2024007859 @default.
• W3192592389 cites W2035125131 @default.
• W3192592389 cites W2036145275 @default.
• W3192592389 cites W2039146307 @default.
• W3192592389 cites W2039846615 @default.
• W3192592389 cites W2063970883 @default.
• W3192592389 cites W2074607512 @default.
• W3192592389 cites W2079491737 @default.
• W3192592389 cites W2095594166 @default.
• W3192592389 cites W2109478767 @default.
• W3192592389 cites W2118015751 @default.
• W3192592389 cites W2121330845 @default.
• W3192592389 cites W2157973267 @default.
• W3192592389 cites W2560449517 @default.
• W3192592389 cites W2595363807 @default.
• W3192592389 cites W2625354806 @default.
• W3192592389 cites W2926581015 @default.
• W3192592389 cites W2945474486 @default.
• W3192592389 cites W3009623318 @default.
• W3192592389 cites W3017575933 @default.
• W3192592389 cites W3037222476 @default.
• W3192592389 cites W3127667298 @default.
• W3192592389 doi "https://doi.org/10.3390/ijms22158189" @default.
• W3192592389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8346968" @default.
• W3192592389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34360954" @default.
• W3192592389 hasPublicationYear "2021" @default.
• W3192592389 type Work @default.
• W3192592389 sameAs 3192592389 @default.
• W3192592389 citedByCount "5" @default.
• W3192592389 countsByYear W31925923892021 @default.
• W3192592389 countsByYear W31925923892022 @default.
• W3192592389 countsByYear W31925923892023 @default.
• W3192592389 crossrefType "journal-article" @default.
• W3192592389 hasAuthorship W3192592389A5023552718 @default.
• W3192592389 hasAuthorship W3192592389A5040249032 @default.
• W3192592389 hasAuthorship W3192592389A5053111848 @default.
• W3192592389 hasAuthorship W3192592389A5063538471 @default.
• W3192592389 hasAuthorship W3192592389A5065993592 @default.
• W3192592389 hasAuthorship W3192592389A5066165238 @default.
• W3192592389 hasAuthorship W3192592389A5076104933 @default.
• W3192592389 hasAuthorship W3192592389A5078083544 @default.
• W3192592389 hasAuthorship W3192592389A5086127651 @default.
• W3192592389 hasBestOaLocation W31925923891 @default.
• W3192592389 hasConcept C104317684 @default.
• W3192592389 hasConcept C12554922 @default.
• W3192592389 hasConcept C138626823 @default.
• W3192592389 hasConcept C181199279 @default.
• W3192592389 hasConcept C185592680 @default.
• W3192592389 hasConcept C189938988 @default.
• W3192592389 hasConcept C190062978 @default.
• W3192592389 hasConcept C2780723820 @default.
• W3192592389 hasConcept C55493867 @default.
• W3192592389 hasConcept C86339819 @default.
• W3192592389 hasConcept C86803240 @default.
• W3192592389 hasConcept C95444343 @default.
• W3192592389 hasConcept C98539663 @default.
• W3192592389 hasConceptScore W3192592389C104317684 @default.
• W3192592389 hasConceptScore W3192592389C12554922 @default.
• W3192592389 hasConceptScore W3192592389C138626823 @default.
• W3192592389 hasConceptScore W3192592389C181199279 @default.
• W3192592389 hasConceptScore W3192592389C185592680 @default.
• W3192592389 hasConceptScore W3192592389C189938988 @default.
• W3192592389 hasConceptScore W3192592389C190062978 @default.
• W3192592389 hasConceptScore W3192592389C2780723820 @default.
• W3192592389 hasConceptScore W3192592389C55493867 @default.
• W3192592389 hasConceptScore W3192592389C86339819 @default.
• W3192592389 hasConceptScore W3192592389C86803240 @default.
• W3192592389 hasConceptScore W3192592389C95444343 @default.
• W3192592389 hasConceptScore W3192592389C98539663 @default.
• W3192592389 hasFunder F4320321181 @default.
• W3192592389 hasIssue "15" @default.
• W3192592389 hasLocation W31925923891 @default.
• W3192592389 hasLocation W31925923892 @default.
• W3192592389 hasLocation W31925923893 @default.
• W3192592389 hasLocation W31925923894 @default.
• W3192592389 hasOpenAccess W3192592389 @default.
• W3192592389 hasPrimaryLocation W31925923891 @default.
• W3192592389 hasRelatedWork W1847300260 @default.
• W3192592389 hasRelatedWork W1978285033 @default.
• W3192592389 hasRelatedWork W1995006248 @default.
• W3192592389 hasRelatedWork W2080560850 @default.

• next