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- W3192670554 abstract "The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we discovered a subset of tumor endothelial cells that facilitate nanoparticle transport into solid tumors. We named these cells nanoparticle transport endothelial cells (N-TECs). We show that only 21% of tumor endothelial cells located on a small number of vessels are involved in transporting nanoparticles into the tumor microenvironment. N-TECs have an increased expression of genes related to nanoparticle transport and vessel permeability compared to other tumor endothelial cells. The N-TECs act as gatekeepers that determine the entry point, distribution, cell accessibility, and number of nanoparticles that enter the tumor microenvironment." @default.
- W3192670554 created "2021-08-16" @default.
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- W3192670554 date "2021-08-12" @default.
- W3192670554 modified "2023-10-14" @default.
- W3192670554 title "Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors" @default.
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- W3192670554 doi "https://doi.org/10.1021/acsnano.1c04510" @default.
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