Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192681008> ?p ?o ?g. }
- W3192681008 endingPage "1485" @default.
- W3192681008 startingPage "1474" @default.
- W3192681008 abstract "Small noncoding RNAs (sRNAs) play important roles during the oocyte-to-embryo transition (OET), when the maternal phenotype is reprogrammed and the embryo genome is gradually activated. The transcriptional program driving early human development has been studied with the focus mainly on protein-coding RNAs, and expression dynamics of sRNAs remain largely unexplored. We profiled sRNAs in human oocytes and early embryos using an RNA-sequencing (RNA-seq) method suitable for low inputs of material. We show that OET in humans is temporally coupled with the transition from predominant expression of oocyte short piRNAs (os-piRNAs) in oocytes, to activation of microRNA (miRNA) expression in cleavage stage embryos. Additionally, 3′ mono- and oligoadenylation of miRNAs is markedly increased in zygotes. We hypothesize that this may modulate the function or stability of maternal miRNAs, some of which are retained throughout the first cell divisions in embryos. This study is the first of its kind elucidating the dynamics of sRNA expression and miRNA modification along a continuous trajectory of early human development and provides a valuable data set for in-depth interpretative analyses." @default.
- W3192681008 created "2021-08-16" @default.
- W3192681008 creator A5006692498 @default.
- W3192681008 creator A5009732804 @default.
- W3192681008 creator A5012737483 @default.
- W3192681008 creator A5037571237 @default.
- W3192681008 creator A5052683253 @default.
- W3192681008 creator A5053950173 @default.
- W3192681008 creator A5055564008 @default.
- W3192681008 creator A5056524738 @default.
- W3192681008 creator A5065418263 @default.
- W3192681008 creator A5087505957 @default.
- W3192681008 date "2021-08-01" @default.
- W3192681008 modified "2023-10-16" @default.
- W3192681008 title "Small RNA expression and miRNA modification dynamics in human oocytes and early embryos" @default.
- W3192681008 cites W1552664666 @default.
- W3192681008 cites W1788141003 @default.
- W3192681008 cites W1954530082 @default.
- W3192681008 cites W1964631913 @default.
- W3192681008 cites W1969104747 @default.
- W3192681008 cites W1970561408 @default.
- W3192681008 cites W1982828671 @default.
- W3192681008 cites W1987205085 @default.
- W3192681008 cites W1994211366 @default.
- W3192681008 cites W2003184107 @default.
- W3192681008 cites W2006247279 @default.
- W3192681008 cites W2007439698 @default.
- W3192681008 cites W2009170663 @default.
- W3192681008 cites W2020833650 @default.
- W3192681008 cites W2021195009 @default.
- W3192681008 cites W2032803538 @default.
- W3192681008 cites W2032964111 @default.
- W3192681008 cites W2035886282 @default.
- W3192681008 cites W2035930185 @default.
- W3192681008 cites W2036373513 @default.
- W3192681008 cites W2036961190 @default.
- W3192681008 cites W2040058302 @default.
- W3192681008 cites W2049868101 @default.
- W3192681008 cites W2061556094 @default.
- W3192681008 cites W2063337177 @default.
- W3192681008 cites W2067954811 @default.
- W3192681008 cites W2069009920 @default.
- W3192681008 cites W2072636314 @default.
- W3192681008 cites W2077327925 @default.
- W3192681008 cites W2078628283 @default.
- W3192681008 cites W2086752139 @default.
- W3192681008 cites W2089055162 @default.
- W3192681008 cites W2099728493 @default.
- W3192681008 cites W2101543035 @default.
- W3192681008 cites W2102619694 @default.
- W3192681008 cites W2102992332 @default.
- W3192681008 cites W2103012554 @default.
- W3192681008 cites W2103913095 @default.
- W3192681008 cites W2107444074 @default.
- W3192681008 cites W2108284151 @default.
- W3192681008 cites W2109923675 @default.
- W3192681008 cites W2110065044 @default.
- W3192681008 cites W2112703265 @default.
- W3192681008 cites W2115440295 @default.
- W3192681008 cites W2117134922 @default.
- W3192681008 cites W2119480083 @default.
- W3192681008 cites W2121905822 @default.
- W3192681008 cites W2124985265 @default.
- W3192681008 cites W2130305733 @default.
- W3192681008 cites W2134394278 @default.
- W3192681008 cites W2135447722 @default.
- W3192681008 cites W2135837360 @default.
- W3192681008 cites W2137526110 @default.
- W3192681008 cites W2142515731 @default.
- W3192681008 cites W2142574304 @default.
- W3192681008 cites W2146512944 @default.
- W3192681008 cites W2146580193 @default.
- W3192681008 cites W2148105495 @default.
- W3192681008 cites W2149146453 @default.
- W3192681008 cites W2153974400 @default.
- W3192681008 cites W2155412493 @default.
- W3192681008 cites W2162675434 @default.
- W3192681008 cites W2177297951 @default.
- W3192681008 cites W2273997940 @default.
- W3192681008 cites W2342051973 @default.
- W3192681008 cites W2409262378 @default.
- W3192681008 cites W2588828267 @default.
- W3192681008 cites W2610997427 @default.
- W3192681008 cites W2737162496 @default.
- W3192681008 cites W2747899047 @default.
- W3192681008 cites W2793078357 @default.
- W3192681008 cites W2886514991 @default.
- W3192681008 cites W2898440040 @default.
- W3192681008 cites W2901318957 @default.
- W3192681008 cites W2935818642 @default.
- W3192681008 cites W2945288061 @default.
- W3192681008 cites W2950758817 @default.
- W3192681008 cites W2964560715 @default.
- W3192681008 cites W2971941967 @default.
- W3192681008 cites W2995905556 @default.
- W3192681008 cites W3004613021 @default.
- W3192681008 cites W3009881134 @default.
- W3192681008 cites W3038599224 @default.