FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192691126> ?p ?o ?g. }

• W3192691126 endingPage "332" @default.
• W3192691126 startingPage "305" @default.
• W3192691126 abstract "Progress on targeted pulmonary delivery of inhaled drugs has come with new challenges in formulation and pharmacokinetics. These include delivery of high-dose drugs (e.g. antibiotics) and solving the physical stability issues of amorphous powders produced in the production process (e.g. jet milling, spray drying). While generic inhalation products can alleviate the health cost burden, dry powder formulations require careful matching of the interaction forces between the active ingredients and lactose carriers, and also between the formulation and the inhaler. Biologics and macromolecules continue to be important therapeutics, but their delivery requires maintenance of the biological stability of the macromolecules in the formulation. Currently, there is no controlled release inhalation product on the market. A major concern is the toxicity of excipients used such formulations as certain polymers may cause inflammation in the lungs. Liposomes which resemble endogenous lipids so far have been the most promising candidates for repeated lung dosing. The fate of inhaled drugs in the body is determined by both the physicochemical characteristics of the drug (e.g. lipophilicity and molecular weight) and the anatomical and histological characteristics of the respiratory system (e.g. large airways vs alveoli). These factors will depend on whether the drug is for local action or systemic effect. Pharmacokinetic/pharmacodynamic (PK/PD) correlation of clinically approved inhaled drugs is discussed for corticosteroids and bronchodilators, antimicrobials, prostacyclin analogs, antipsychotics, and insulin. Further improvement of PK/PD parameters of inhaled drugs could be considered via chemical modification, functional micro/nanoparticle formulations, and active targeting strategies." @default.
• W3192691126 created "2021-08-16" @default.
• W3192691126 creator A5026820693 @default.
• W3192691126 creator A5063947325 @default.
• W3192691126 date "2021-07-27" @default.
• W3192691126 modified "2023-10-12" @default.
• W3192691126 title "Formulation and Pharmacokinetic Challenges Associated with Targeted Pulmonary Drug Delivery" @default.
• W3192691126 cites W1530050238 @default.
• W3192691126 cites W1582180916 @default.
• W3192691126 cites W1751557895 @default.
• W3192691126 cites W1775281360 @default.
• W3192691126 cites W1964048008 @default.
• W3192691126 cites W1964196183 @default.
• W3192691126 cites W1966580084 @default.
• W3192691126 cites W1966678025 @default.
• W3192691126 cites W1969556564 @default.
• W3192691126 cites W1973746542 @default.
• W3192691126 cites W1975163309 @default.
• W3192691126 cites W1977176265 @default.
• W3192691126 cites W1982181124 @default.
• W3192691126 cites W1984477495 @default.
• W3192691126 cites W1984548348 @default.
• W3192691126 cites W1986410429 @default.
• W3192691126 cites W1989837791 @default.
• W3192691126 cites W1990455420 @default.
• W3192691126 cites W1992445150 @default.
• W3192691126 cites W199344471 @default.
• W3192691126 cites W1998445104 @default.
• W3192691126 cites W1998867182 @default.
• W3192691126 cites W2002317391 @default.
• W3192691126 cites W2004931777 @default.
• W3192691126 cites W2010097193 @default.
• W3192691126 cites W2011328385 @default.
• W3192691126 cites W2013812391 @default.
• W3192691126 cites W2015299325 @default.
• W3192691126 cites W2020623049 @default.
• W3192691126 cites W2024920372 @default.
• W3192691126 cites W2025126892 @default.
• W3192691126 cites W2026155341 @default.
• W3192691126 cites W2029838701 @default.
• W3192691126 cites W2031714172 @default.
• W3192691126 cites W2033707373 @default.
• W3192691126 cites W2036325897 @default.
• W3192691126 cites W2037842504 @default.
• W3192691126 cites W2039799423 @default.
• W3192691126 cites W2042139615 @default.
• W3192691126 cites W2043768346 @default.
• W3192691126 cites W2044636805 @default.
• W3192691126 cites W2045639035 @default.
• W3192691126 cites W2049209536 @default.
• W3192691126 cites W2050730934 @default.
• W3192691126 cites W2054636074 @default.
• W3192691126 cites W2055750804 @default.
• W3192691126 cites W2057682847 @default.
• W3192691126 cites W2057863104 @default.
• W3192691126 cites W2058889783 @default.
• W3192691126 cites W2059120996 @default.
• W3192691126 cites W2062181861 @default.
• W3192691126 cites W2064545080 @default.
• W3192691126 cites W2064597317 @default.
• W3192691126 cites W2065176007 @default.
• W3192691126 cites W2069869192 @default.
• W3192691126 cites W2070362125 @default.
• W3192691126 cites W2070693357 @default.
• W3192691126 cites W2073463374 @default.
• W3192691126 cites W2075069205 @default.
• W3192691126 cites W2075771522 @default.
• W3192691126 cites W2076476870 @default.
• W3192691126 cites W2077722212 @default.
• W3192691126 cites W2079436667 @default.
• W3192691126 cites W2086033059 @default.
• W3192691126 cites W2090296464 @default.
• W3192691126 cites W2092482435 @default.
• W3192691126 cites W2094858738 @default.
• W3192691126 cites W2096786557 @default.
• W3192691126 cites W2097575804 @default.
• W3192691126 cites W2098743612 @default.
• W3192691126 cites W2099415804 @default.
• W3192691126 cites W2105393448 @default.
• W3192691126 cites W2106549324 @default.
• W3192691126 cites W2107798013 @default.
• W3192691126 cites W2108994281 @default.
• W3192691126 cites W2110155430 @default.
• W3192691126 cites W2110471088 @default.
• W3192691126 cites W2111717676 @default.
• W3192691126 cites W2115591045 @default.
• W3192691126 cites W2117751773 @default.
• W3192691126 cites W2124596793 @default.
• W3192691126 cites W2127654256 @default.
• W3192691126 cites W2148934136 @default.
• W3192691126 cites W2152386842 @default.
• W3192691126 cites W2155062388 @default.
• W3192691126 cites W2155519854 @default.
• W3192691126 cites W2155526894 @default.
• W3192691126 cites W2158221216 @default.
• W3192691126 cites W2158593151 @default.
• W3192691126 cites W2160027607 @default.
• W3192691126 cites W2161605184 @default.

• next