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- W3192823088 abstract "This is a young, otherwise healthy patient with a bulky, Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma. Given the high initial disease burden, we would recommend 3 cycles of induction chemotherapy (gemcitabine 1000 mg/m2 days 1 and 8; cisplatin 80 mg/m2 day 1), followed by concurrent chemoradiation. In contrast to adults, for whom evidence supporting response-adapted dosing is lacking, a prospective pediatric trial (ARAR0331) provides a convincing rationale to reduce doses in the setting of complete or partial response to induction chemotherapy for nonkeratinizing nasopharyngeal carcinoma. 1 Rodriguez-Galindo C Krailo MD Krasin MJ et al. Treatment of childhood nasopharyngeal carcinoma with induction chemotherapy and concurrent chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 study. J Clin Oncol. 2019; 37: 3369-3376 Crossref PubMed Scopus (18) Google Scholar" @default.
- W3192823088 created "2021-08-16" @default.
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- W3192823088 date "2021-09-01" @default.
- W3192823088 modified "2023-09-27" @default.
- W3192823088 title "Keeping Kids Kool—Influence of Induction, Advantage of Adaptation, Curtailment of Complications" @default.
- W3192823088 cites W2973956548 @default.
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- W3192823088 doi "https://doi.org/10.1016/j.ijrobp.2021.04.035" @default.
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