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• W3192827506 endingPage "113500" @default.
• W3192827506 startingPage "113500" @default.
• W3192827506 abstract "Diabetic nephropathy (DN) is a major complication of diabetes. The kidney disease develops in nearly 20%–40% of type 2 diabetes (T2D) patients. Ginseng is the root of Panax ginseng C. A. Meyer and has been used in prevention and treatment of diseases for more than 2000 years as a traditional oriental medicine. The 20(R)-ginsenoside Rg3, an active saponin isolated from ginseng, can prevent and treat many diseases. The object of this research was to explore the alleviative effects of 20(R)-Rg3 on DN in mice. The T2D animal model was induced by continuous access to a high fat diet (HFD) combined with a single injection of 100 mg/kg streptozotocin (STZ) in C57BL/6 mice. The mice were treated by oral gavage of the 20(R)-Rg3 (10, 20 mg/kg) for 8 weeks. Functional and histopathological analyses of the kidneys were then performed. Protein expression levels of MAPKs and NF-κB signal pathways in the kidney were evaluated by western blotting. The expressions of HO-1 and NF-κB in the kidney were measured by fluorescent labeling staining. Other assessments including fasting blood glucose (FBG) levels, blood lipids, oxidative indicators, and inflammatory factors were all performed. Abnormally elevated FBG levels were observed in HFD/STZ mice, contributing significantly to the occurrence of DN. Simultaneously, HFD/STZ mice showed the rise of serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels, and the decrease in high density lipoprotein cholesterol (HDL-C). DN was evidenced by the overproduction of malondialdehyde (MDA), decreased levels of superoxide dismutase (SOD) and catalase (CAT) enzymatic activities, high levels of serum blood urea nitrogen (BUN) and creatinine (Cr). Simultaneously, the results of the immunofluorescence assay showed an increased expression level in NF-κB p65 while a decrease in antioxidant enzyme HO-1 was observed. Herein, 20(R)-Rg3 treatment for 8 weeks not only attenuated FBG levels and advanced glycation end products (AGEs) levels but also improved insulin (INS) level, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF-κB signal pathways in DN mice. Taken together, the findings from the present study explicitly confirmed that 20(R)-Rg3 exerted ameliorative effects on DN mice via improving anti-oxidative activity and reducing renal inflammation." @default.
• W3192827506 created "2021-08-16" @default.
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• W3192827506 date "2021-03-01" @default.
• W3192827506 modified "2023-10-16" @default.
• W3192827506 title "Alleviative effects of 20(R)-Rg3 on HFD/STZ-induced diabetic nephropathy via MAPK/NF-κB signaling pathways in C57BL/6 mice" @default.
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• W3192827506 cites W2003291247 @default.
• W3192827506 cites W2041541039 @default.
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• W3192827506 cites W2049261270 @default.
• W3192827506 cites W2058437683 @default.
• W3192827506 cites W2058776339 @default.
• W3192827506 cites W2070118415 @default.
• W3192827506 cites W2074652188 @default.
• W3192827506 cites W2078993054 @default.
• W3192827506 cites W2083053990 @default.
• W3192827506 cites W2083911580 @default.
• W3192827506 cites W2086779652 @default.
• W3192827506 cites W2097887036 @default.
• W3192827506 cites W2103437560 @default.
• W3192827506 cites W2104916182 @default.
• W3192827506 cites W2106901492 @default.
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• W3192827506 cites W2121000910 @default.
• W3192827506 cites W2130176433 @default.
• W3192827506 cites W2133801172 @default.
• W3192827506 cites W2143779541 @default.
• W3192827506 cites W2146310869 @default.
• W3192827506 cites W2149848093 @default.
• W3192827506 cites W2151223245 @default.
• W3192827506 cites W2162478006 @default.
• W3192827506 cites W2195599830 @default.
• W3192827506 cites W2195961008 @default.
• W3192827506 cites W2208212778 @default.
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• W3192827506 cites W2516337081 @default.
• W3192827506 cites W2597308177 @default.
• W3192827506 cites W2608245224 @default.
• W3192827506 cites W2618746079 @default.
• W3192827506 cites W2737432080 @default.
• W3192827506 cites W2742290492 @default.
• W3192827506 cites W2742741939 @default.
• W3192827506 cites W2753524716 @default.
• W3192827506 cites W2757144107 @default.
• W3192827506 cites W2758486259 @default.
• W3192827506 cites W2761398933 @default.
• W3192827506 cites W2766555262 @default.
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• W3192827506 doi "https://doi.org/10.1016/j.jep.2020.113500" @default.
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• W3192827506 hasPublicationYear "2021" @default.
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