Matches in SemOpenAlex for { <https://semopenalex.org/work/W3192874168> ?p ?o ?g. }
- W3192874168 abstract "Endothelial-to-mesenchymal transition (EndMT) is the biological process through which endothelial cells transdifferentiate into mesenchymal cells. During embryo development, EndMT regulates endocardial cushion formation via TGFβ/BMP signaling. In adults, EndMT is mainly activated during pathological conditions. Hence, it is necessary to characterize molecular regulators cooperating with TGFβ signaling in driving EndMT, to identify potential novel therapeutic targets to treat these pathologies. Here, we studied YAP, a transcriptional co-regulator involved in several biological processes, including epithelial-to-mesenchymal transition (EMT). As EndMT is the endothelial-specific form of EMT, and YAP (herein referring to YAP1) and TGFβ signaling cross-talk in other contexts, we hypothesized that YAP contributes to EndMT by modulating TGFβ signaling. We demonstrate that YAP is required to trigger TGFβ-induced EndMT response, specifically contributing to SMAD3-driven EndMT early gene transcription. We provide novel evidence that YAP acts as SMAD3 transcriptional co-factor and prevents GSK3β-mediated SMAD3 phosphorylation, thus protecting SMAD3 from degradation. YAP is therefore emerging as a possible candidate target to inhibit pathological TGFβ-induced EndMT at early stages." @default.
- W3192874168 created "2021-08-16" @default.
- W3192874168 creator A5009709158 @default.
- W3192874168 creator A5013710631 @default.
- W3192874168 creator A5015370566 @default.
- W3192874168 creator A5034430293 @default.
- W3192874168 creator A5043976139 @default.
- W3192874168 creator A5048809643 @default.
- W3192874168 creator A5049264621 @default.
- W3192874168 creator A5050821662 @default.
- W3192874168 creator A5063563088 @default.
- W3192874168 creator A5091355800 @default.
- W3192874168 date "2021-08-01" @default.
- W3192874168 modified "2023-10-15" @default.
- W3192874168 title "A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition" @default.
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