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• W3192935609 abstract "Purpose To evaluate the reliability of ultrasound hepatorenal index (US-HRI) and magnetic resonance imaging proton density fat fraction (MRI-PDFF) techniques in the diagnosis of hepatic steatosis, with magnetic resonance spectroscopy proton density fat fraction (MRS-PDFF) as the reference standard. Materials and methods Fifty-two adult volunteers (30 men, 22 women; age, 31.5 ± 6.5 years) who had no history of kidney disease or viral/alcoholic hepatitis were recruited to undergo abdominal US, MRI, and MRS examinations. US-HRI was calculated from the average of three pairs of regions of interest (ROIs) measurements placed in the liver parenchyma and right renal cortex. On MRI, the six-point Dixon technique was employed for calculating proton density fat fraction (MRI-PDFF). An MRS sequence with a typical voxel size of 27 ml was chosen to estimate MRS-PDFF as the gold standard. The data were evaluated using Pearson’s correlation coefficient and receiver operating characteristic (ROC) curves. Results The Pearson correlation coefficients of US-HRI and MRI-PDFF with MRS-PDFF were 0.38 ( p = 0.005) and 0.95 ( p <0.001), respectively. If MRS-PDFF ≥5.56% was defined as the gold standard of fatty liver disease, the areas under the curve (AUCs), cut-off values, sensitivities and specificities of US-HRI and MRI-PDFF were 0.74, 1.54, 50%, 91.7% and 0.99, 2.75%, 100%, 88.9%, respectively. The intraclass correlation coefficients (ICCs) of US-HRI and MRI-PDFF were 0.70 and 0.85. Conclusion MRI-PDFF was more reliable than US-HRI in diagnosing hepatic steatosis." @default.
• W3192935609 created "2021-08-16" @default.
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• W3192935609 date "2021-08-12" @default.
• W3192935609 modified "2023-10-14" @default.
• W3192935609 title "Reliability of ultrasound hepatorenal index and magnetic resonance imaging proton density fat fraction techniques in the diagnosis of hepatic steatosis, with magnetic resonance spectroscopy as the reference standard" @default.
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• W3192935609 doi "https://doi.org/10.1371/journal.pone.0255768" @default.
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