FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193131441> ?p ?o ?g. }

• W3193131441 endingPage "829" @default.
• W3193131441 startingPage "820" @default.
• W3193131441 abstract "Drugs that prolong the QT interval, either by design (cardiac QT-prolonging drugs: anti-arrhythmics) or as off-target effect (non-cardiac QT-prolonging drugs), may increase the risk of ventricular arrhythmias and out-of-hospital cardiac arrest (OHCA). Risk mitigation measures were instituted, in particular, surrounding prescription of cardiac QT-prolonging drugs. We studied OHCA risk of both drug types in current clinical practice.Using data from large population-based OHCA registries in the Netherlands and Denmark, we conducted two independent case-control studies. OHCA cases with presumed cardiac causes were matched on age/sex/index date with up to five non-OHCA controls. We calculated odds ratios (ORs) for the association of cardiac or non-cardiac QT-prolonging drugs with OHCA risk using conditional logistic regression analyses.We identified 2503 OHCA cases and 10 543 non-OHCA controls in the Netherlands, and 35 017 OHCA cases and 175 085 non-OHCA controls in Denmark. Compared to no use of QT-prolonging drugs, use of non-cardiac QT-prolonging drugs (Netherlands: cases: 3.0%, controls: 1.9%; Denmark: cases: 14.9%, controls: 7.5%) was associated with increased OHCA risk (Netherlands: OR 1.37 [95% CI: 1.03-1.81]; Denmark: OR 1.63 [95% CI: 1.57-1.70]). The association between cardiac QT-prolonging drugs (Netherlands: cases: 4.0%, controls: 2.5%; Denmark: cases: 2.1%, controls: 0.9%) and OHCA was weaker (Netherlands: OR 1.17 [95% CI: 0.92-1.50]; Denmark: OR 1.21 [95% CI: 1.09-1.33]), although users of cardiac QT-prolonging drugs had more medication use and comorbidities associated with OHCA risk than users of non-cardiac QT-prolonging drugs.In clinical practice, cardiac QT-prolonging drugs confer lower OHCA risk than non-cardiac QT-prolonging drugs, although users of the former have higher a priori risk. This is likely due to risk mitigation measures surrounding prescription of cardiac QT-prolonging drugs." @default.
• W3193131441 created "2021-08-16" @default.
• W3193131441 creator A5001085249 @default.
• W3193131441 creator A5001183979 @default.
• W3193131441 creator A5005015110 @default.
• W3193131441 creator A5013224321 @default.
• W3193131441 creator A5022924515 @default.
• W3193131441 creator A5025359400 @default.
• W3193131441 creator A5039442834 @default.
• W3193131441 creator A5041526130 @default.
• W3193131441 creator A5053585075 @default.
• W3193131441 creator A5077437482 @default.
• W3193131441 creator A5078618702 @default.
• W3193131441 creator A5084013498 @default.
• W3193131441 date "2021-08-28" @default.
• W3193131441 modified "2023-10-16" @default.
• W3193131441 title "Out‐of‐hospital cardiac arrest and differential risk of cardiac and non‐cardiac QT‐prolonging drugs in 37 000 cases" @default.
• W3193131441 cites W1545972634 @default.
• W3193131441 cites W1974394531 @default.
• W3193131441 cites W1978038329 @default.
• W3193131441 cites W1987045148 @default.
• W3193131441 cites W1991053107 @default.
• W3193131441 cites W1995892597 @default.
• W3193131441 cites W2005411701 @default.
• W3193131441 cites W2009299561 @default.
• W3193131441 cites W2018841001 @default.
• W3193131441 cites W2038341506 @default.
• W3193131441 cites W2052085254 @default.
• W3193131441 cites W2097582584 @default.
• W3193131441 cites W2099885515 @default.
• W3193131441 cites W2113102918 @default.
• W3193131441 cites W2118617344 @default.
• W3193131441 cites W2126195383 @default.
• W3193131441 cites W2131308754 @default.
• W3193131441 cites W2138784551 @default.
• W3193131441 cites W2143518969 @default.
• W3193131441 cites W2144841609 @default.
• W3193131441 cites W2152641996 @default.
• W3193131441 cites W2184673880 @default.
• W3193131441 cites W2223162038 @default.
• W3193131441 cites W2334052098 @default.
• W3193131441 cites W2519495863 @default.
• W3193131441 cites W2614168425 @default.
• W3193131441 cites W2787012156 @default.
• W3193131441 cites W2790131559 @default.
• W3193131441 cites W2944479088 @default.
• W3193131441 cites W2967551454 @default.
• W3193131441 cites W3015960772 @default.
• W3193131441 cites W3193131441 @default.
• W3193131441 cites W4246000128 @default.
• W3193131441 cites W4254462900 @default.
• W3193131441 cites W2056696855 @default.
• W3193131441 doi "https://doi.org/10.1111/bcp.15030" @default.
• W3193131441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34374122" @default.
• W3193131441 hasPublicationYear "2021" @default.
• W3193131441 type Work @default.
• W3193131441 sameAs 3193131441 @default.
• W3193131441 citedByCount "5" @default.
• W3193131441 countsByYear W31931314412021 @default.
• W3193131441 countsByYear W31931314412022 @default.
• W3193131441 countsByYear W31931314412023 @default.
• W3193131441 crossrefType "journal-article" @default.
• W3193131441 hasAuthorship W3193131441A5001085249 @default.
• W3193131441 hasAuthorship W3193131441A5001183979 @default.
• W3193131441 hasAuthorship W3193131441A5005015110 @default.
• W3193131441 hasAuthorship W3193131441A5013224321 @default.
• W3193131441 hasAuthorship W3193131441A5022924515 @default.
• W3193131441 hasAuthorship W3193131441A5025359400 @default.
• W3193131441 hasAuthorship W3193131441A5039442834 @default.
• W3193131441 hasAuthorship W3193131441A5041526130 @default.
• W3193131441 hasAuthorship W3193131441A5053585075 @default.
• W3193131441 hasAuthorship W3193131441A5077437482 @default.
• W3193131441 hasAuthorship W3193131441A5078618702 @default.
• W3193131441 hasAuthorship W3193131441A5084013498 @default.
• W3193131441 hasBestOaLocation W31931314411 @default.
• W3193131441 hasConcept C118441451 @default.
• W3193131441 hasConcept C126322002 @default.
• W3193131441 hasConcept C151956035 @default.
• W3193131441 hasConcept C156957248 @default.
• W3193131441 hasConcept C164705383 @default.
• W3193131441 hasConcept C2426938 @default.
• W3193131441 hasConcept C2775935837 @default.
• W3193131441 hasConcept C2779703243 @default.
• W3193131441 hasConcept C42219234 @default.
• W3193131441 hasConcept C71924100 @default.
• W3193131441 hasConcept C98274493 @default.
• W3193131441 hasConceptScore W3193131441C118441451 @default.
• W3193131441 hasConceptScore W3193131441C126322002 @default.
• W3193131441 hasConceptScore W3193131441C151956035 @default.
• W3193131441 hasConceptScore W3193131441C156957248 @default.
• W3193131441 hasConceptScore W3193131441C164705383 @default.
• W3193131441 hasConceptScore W3193131441C2426938 @default.
• W3193131441 hasConceptScore W3193131441C2775935837 @default.
• W3193131441 hasConceptScore W3193131441C2779703243 @default.
• W3193131441 hasConceptScore W3193131441C42219234 @default.
• W3193131441 hasConceptScore W3193131441C71924100 @default.
• W3193131441 hasConceptScore W3193131441C98274493 @default.
• W3193131441 hasFunder F4320321642 @default.

• next