FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193140168> ?p ?o ?g. }

• W3193140168 endingPage "155662" @default.
• W3193140168 startingPage "155662" @default.
• W3193140168 abstract "Elevated Interleukin-6 (IL-6) may play an important role in the pathophysiology of COVID-19 yet attenuated response is not seen across all severe patients. We aimed to determine the effect of IL-6 baseline levels and other clinical variables on mortality and outcomes in hospitalized COVID-19 patients as well as to explore genetic variants associated with attenuated IL-6 response. Baseline IL-6 cytokine levels were measured in hospitalized patients participating in ongoing ODYSSEY phase 3 randomized study of tradipitant and placebo in hospitalized patients with severe COVID-19 who are receiving supplemental oxygen support. Furthermore blood samples for whole genome sequencing analysis were collected from 150 participants. We report significantly elevated IL-6 in COVID-19 infected hospitalized patients, n = 100 (p-value < 0.0001) when compared to controls n = 324. We also report a significantly increased level of IL-6 (p-value < 0.01) between the severe and mild COVID-19 patients with severity defined on a WHO scale. Excessive IL-6 plasma levels correlate with higher mortality (p-value 0.001). Additionally, based on our classification analysis, combination of IL-6 elevation and high levels of serum glucose can identify highest risk-group of COVID19 patients. Furthermore, we explore the role of genetic regulatory variants affecting baseline IL-6 levels specifically in COVID-19 patients. We have directly tested the association between variants in the IL6 and IL6R gene region and IL6 plasma levels. We provide results for a common IL-6 variant previously associated with pneumonia, rs1800795, and rs2228145 that was previously shown to affect IL-6 plasma levels, as well as report on novel variants associated with IL-6 plasma levels detected in our study patients. While it is unlikely that “cytokine storm” is the norm in severe COVID19, baseline elevations above 150 pg/ml may be associated with worst outcomes and as such may warrant treatment considerations. So far no clinical studies used IL-6 baseline assessment to stratify the patient population participating in clinical studies. We believe that careful examination and interpretation of the IL-6 levels and genetic variants can help to determine a patient population with a potentially very robust clinical response to IL-6 inhibition. Trial Registration: Clinicaltrials.gov: NCT04326426." @default.
• W3193140168 created "2021-08-16" @default.
• W3193140168 creator A5022299669 @default.
• W3193140168 creator A5031674961 @default.
• W3193140168 creator A5040301246 @default.
• W3193140168 creator A5079657055 @default.
• W3193140168 date "2021-12-01" @default.
• W3193140168 modified "2023-09-24" @default.
• W3193140168 title "Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients’" @default.
• W3193140168 cites W1993255002 @default.
• W3193140168 cites W2018838463 @default.
• W3193140168 cites W2033600061 @default.
• W3193140168 cites W2043070494 @default.
• W3193140168 cites W2046613841 @default.
• W3193140168 cites W2092913811 @default.
• W3193140168 cites W2120902911 @default.
• W3193140168 cites W2804481833 @default.
• W3193140168 cites W2805452148 @default.
• W3193140168 cites W2951219574 @default.
• W3193140168 cites W3022970339 @default.
• W3193140168 cites W3039983944 @default.
• W3193140168 cites W3048885045 @default.
• W3193140168 cites W3082201689 @default.
• W3193140168 cites W3130937313 @default.
• W3193140168 doi "https://doi.org/10.1016/j.cyto.2021.155662" @default.
• W3193140168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8318728" @default.
• W3193140168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34353696" @default.
• W3193140168 hasPublicationYear "2021" @default.
• W3193140168 type Work @default.
• W3193140168 sameAs 3193140168 @default.
• W3193140168 citedByCount "17" @default.
• W3193140168 countsByYear W31931401682021 @default.
• W3193140168 countsByYear W31931401682022 @default.
• W3193140168 countsByYear W31931401682023 @default.
• W3193140168 crossrefType "journal-article" @default.
• W3193140168 hasAuthorship W3193140168A5022299669 @default.
• W3193140168 hasAuthorship W3193140168A5031674961 @default.
• W3193140168 hasAuthorship W3193140168A5040301246 @default.
• W3193140168 hasAuthorship W3193140168A5079657055 @default.
• W3193140168 hasBestOaLocation W31931401681 @default.
• W3193140168 hasConcept C10162356 @default.
• W3193140168 hasConcept C11988809 @default.
• W3193140168 hasConcept C126322002 @default.
• W3193140168 hasConcept C142724271 @default.
• W3193140168 hasConcept C204787440 @default.
• W3193140168 hasConcept C27081682 @default.
• W3193140168 hasConcept C2777914695 @default.
• W3193140168 hasConcept C2778690821 @default.
• W3193140168 hasConcept C2779134260 @default.
• W3193140168 hasConcept C2779559532 @default.
• W3193140168 hasConcept C30036603 @default.
• W3193140168 hasConcept C3008058167 @default.
• W3193140168 hasConcept C524204448 @default.
• W3193140168 hasConcept C71924100 @default.
• W3193140168 hasConcept C90924648 @default.
• W3193140168 hasConceptScore W3193140168C10162356 @default.
• W3193140168 hasConceptScore W3193140168C11988809 @default.
• W3193140168 hasConceptScore W3193140168C126322002 @default.
• W3193140168 hasConceptScore W3193140168C142724271 @default.
• W3193140168 hasConceptScore W3193140168C204787440 @default.
• W3193140168 hasConceptScore W3193140168C27081682 @default.
• W3193140168 hasConceptScore W3193140168C2777914695 @default.
• W3193140168 hasConceptScore W3193140168C2778690821 @default.
• W3193140168 hasConceptScore W3193140168C2779134260 @default.
• W3193140168 hasConceptScore W3193140168C2779559532 @default.
• W3193140168 hasConceptScore W3193140168C30036603 @default.
• W3193140168 hasConceptScore W3193140168C3008058167 @default.
• W3193140168 hasConceptScore W3193140168C524204448 @default.
• W3193140168 hasConceptScore W3193140168C71924100 @default.
• W3193140168 hasConceptScore W3193140168C90924648 @default.
• W3193140168 hasLocation W31931401681 @default.
• W3193140168 hasLocation W31931401682 @default.
• W3193140168 hasLocation W31931401683 @default.
• W3193140168 hasOpenAccess W3193140168 @default.
• W3193140168 hasPrimaryLocation W31931401681 @default.
• W3193140168 hasRelatedWork W2159140922 @default.
• W3193140168 hasRelatedWork W3026277345 @default.
• W3193140168 hasRelatedWork W3101342095 @default.
• W3193140168 hasRelatedWork W3107407599 @default.
• W3193140168 hasRelatedWork W3112151336 @default.
• W3193140168 hasRelatedWork W3118803821 @default.
• W3193140168 hasRelatedWork W3153277198 @default.
• W3193140168 hasRelatedWork W4225998741 @default.
• W3193140168 hasRelatedWork W4289262226 @default.
• W3193140168 hasRelatedWork W4312662628 @default.
• W3193140168 hasVolume "148" @default.
• W3193140168 isParatext "false" @default.
• W3193140168 isRetracted "false" @default.
• W3193140168 magId "3193140168" @default.
• W3193140168 workType "article" @default.