FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193150987> ?p ?o ?g. }

• W3193150987 endingPage "503390" @default.
• W3193150987 startingPage "503390" @default.
• W3193150987 abstract "The sodium valproate has been largely used as an anti-epilepsy drug and, recently, as a putative drug in cancer therapy. However, the treatment with sodium valproate has some adverse effects. In this sense, more effective and secure complexes than sodium valproate should be explored in searching for new active drugs. This study aims to evaluate the cytotoxicity of sodium valproate, mixed ternary mononuclear Cu(II) complexes based on valproic acid (VA) with 1,10-phenanthroline (Phen) or 2,2’- bipyridine (Bipy) ligands - [Cu2(Valp)4], [Cu(Valp)2Phen] and [Cu(Valp)2Bipy] - in yeast Saccharomyces cerevisiae, proficient or deficient in different repair pathways, such as base excision repair (BER), nucleotide excision repair (NER), translesion synthesis (TLS), DNA postreplication repair (PRR), homologous recombination (HR) and non-homologous end-joining (NHEJ). The results indicated that the Cu(II) complexes have higher cytotoxicity than sodium valproate in the following order: [Cu(Valp)2Phen] > [Cu(Valp)2Bipy] > [Cu2(Valp)4] > sodium valproate. The treatment with Cu(II) complexes and sodium valproate induced mutations in S. cerevisiae. The data indicated that yeast strains deficient in BER (Ogg1p), NER (complex Rad1p-Rad10p) or TLS (Rev1p, Rev3p and Rad30p) proteins are associated with increased sensitivity to sodium valproate. The BER mutants (ogg1Δ, apn1Δ, rad27Δ, ntg1Δ and ntg2Δ) showed increased sensitivity to Cu(II) complexes. DNA damage induced by the complexes requires proteins from NER (Rad1p and Rad10p), TLS (Rev1p, Rev3p and Rad30p), PRR (Rad6 and Rad18p) and HR (Rad52p and Rad50p) for efficient repair. Therefore, Cu(II) complexes display enhanced cytotoxicity when compared to the sodium valproate and induce distinct DNA lesions, indicating a potential application as cytotoxic agents." @default.
• W3193150987 created "2021-08-16" @default.
• W3193150987 creator A5008599563 @default.
• W3193150987 creator A5038781374 @default.
• W3193150987 creator A5048749554 @default.
• W3193150987 creator A5059141962 @default.
• W3193150987 creator A5062273806 @default.
• W3193150987 creator A5069311115 @default.
• W3193150987 creator A5076706507 @default.
• W3193150987 creator A5088021252 @default.
• W3193150987 creator A5089211751 @default.
• W3193150987 creator A5089451548 @default.
• W3193150987 date "2021-08-01" @default.
• W3193150987 modified "2023-09-30" @default.
• W3193150987 title "Saccharomyces cerevisiae DNA repair pathways involved in repair of lesions induced by mixed ternary mononuclear Cu(II) complexes based on valproic acid with 1,10-phenanthroline or 2,2’- bipyridine ligands" @default.
• W3193150987 cites W183547841 @default.
• W3193150987 cites W1945285849 @default.
• W3193150987 cites W1974267164 @default.
• W3193150987 cites W1977852894 @default.
• W3193150987 cites W1977918604 @default.
• W3193150987 cites W1992271344 @default.
• W3193150987 cites W1999723472 @default.
• W3193150987 cites W2022544775 @default.
• W3193150987 cites W2024827058 @default.
• W3193150987 cites W2039876512 @default.
• W3193150987 cites W2040527477 @default.
• W3193150987 cites W2041220187 @default.
• W3193150987 cites W2057218806 @default.
• W3193150987 cites W2058274661 @default.
• W3193150987 cites W2060486166 @default.
• W3193150987 cites W2068668716 @default.
• W3193150987 cites W2068942574 @default.
• W3193150987 cites W2071934663 @default.
• W3193150987 cites W2077113174 @default.
• W3193150987 cites W2077666970 @default.
• W3193150987 cites W2084111814 @default.
• W3193150987 cites W2087388294 @default.
• W3193150987 cites W2093595958 @default.
• W3193150987 cites W2097018312 @default.
• W3193150987 cites W2101915081 @default.
• W3193150987 cites W2103704452 @default.
• W3193150987 cites W2111001569 @default.
• W3193150987 cites W2130131612 @default.
• W3193150987 cites W2159986229 @default.
• W3193150987 cites W2164311213 @default.
• W3193150987 cites W2199020333 @default.
• W3193150987 cites W2314395576 @default.
• W3193150987 cites W2319825622 @default.
• W3193150987 cites W2346080816 @default.
• W3193150987 cites W2408743616 @default.
• W3193150987 cites W2531350019 @default.
• W3193150987 cites W2543919326 @default.
• W3193150987 cites W2560672496 @default.
• W3193150987 cites W2736937294 @default.
• W3193150987 cites W2788709619 @default.
• W3193150987 cites W2804723602 @default.
• W3193150987 cites W2889037271 @default.
• W3193150987 cites W2904113910 @default.
• W3193150987 cites W2950137068 @default.
• W3193150987 cites W2963701626 @default.
• W3193150987 cites W2979871383 @default.
• W3193150987 cites W2980346588 @default.
• W3193150987 cites W2992348540 @default.
• W3193150987 cites W2999825619 @default.
• W3193150987 cites W3008031219 @default.
• W3193150987 cites W3024748391 @default.
• W3193150987 cites W3091007622 @default.
• W3193150987 doi "https://doi.org/10.1016/j.mrgentox.2021.503390" @default.
• W3193150987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34454693" @default.
• W3193150987 hasPublicationYear "2021" @default.
• W3193150987 type Work @default.
• W3193150987 sameAs 3193150987 @default.
• W3193150987 citedByCount "0" @default.
• W3193150987 crossrefType "journal-article" @default.
• W3193150987 hasAuthorship W3193150987A5008599563 @default.
• W3193150987 hasAuthorship W3193150987A5038781374 @default.
• W3193150987 hasAuthorship W3193150987A5048749554 @default.
• W3193150987 hasAuthorship W3193150987A5059141962 @default.
• W3193150987 hasAuthorship W3193150987A5062273806 @default.
• W3193150987 hasAuthorship W3193150987A5069311115 @default.
• W3193150987 hasAuthorship W3193150987A5076706507 @default.
• W3193150987 hasAuthorship W3193150987A5088021252 @default.
• W3193150987 hasAuthorship W3193150987A5089211751 @default.
• W3193150987 hasAuthorship W3193150987A5089451548 @default.
• W3193150987 hasConcept C102744134 @default.
• W3193150987 hasConcept C104451858 @default.
• W3193150987 hasConcept C109316439 @default.
• W3193150987 hasConcept C134935766 @default.
• W3193150987 hasConcept C169760540 @default.
• W3193150987 hasConcept C178790620 @default.
• W3193150987 hasConcept C185592680 @default.
• W3193150987 hasConcept C202751555 @default.
• W3193150987 hasConcept C2777172819 @default.
• W3193150987 hasConcept C2777576037 @default.
• W3193150987 hasConcept C2778186239 @default.
• W3193150987 hasConcept C2779222958 @default.
• W3193150987 hasConcept C537181965 @default.
• W3193150987 hasConcept C552990157 @default.

• next