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• W3193161436 endingPage "1984" @default.
• W3193161436 startingPage "1984" @default.
• W3193161436 abstract "The hypothalamic-pituitary-thyroid (HPT) axis regulates many critical features in vertebrates. Utilizing TALENs and CRISPR/Cas9 techniques, thyroid-stimulating hormone subunit beta a (tshba), thyroglobulin (tg), and solute carrier family 16 member 2 (slc16a2) mutant zebrafish lines were generated. Among the three mutants, the earliest time point for the significantly altered T3 contents was observed in tshba mutants, which resulted in the most severe defects, including typical defects such as the retardation of inflated anterior swimming bladder (aSB), proper formation of fin ray and posterior squamation (SP), the larval-to-juvenile transition (LTJT) process, juvenile growth retardation, and mating failure. In tg mutants, which are actually compensated with an alternative splicing form, growth retardation was observed in the juvenile stage without LTJT and reproductive defects. The evident goiter phenotype was only observed in tg- and slc16a2 mutants, but not in tshba mutants. Other than goiters being observed, no other significant developmental defects were found in the slc16a2 mutants. Regarding the reproductive defects observed in tshba mutants, the defective formation of the secondary sex characteristics (SSCs) was observed, while no obvious alterations during gonad development were found. Based on our analyses, zebrafish at the 6-12 mm standard length or 16-35 days post-fertilization (dpf) should be considered to be in their LTJT phase. Using a series of zebrafish dyshormonogenesis models, this study demonstrated that the TSH function is critical for the proper promotion of zebrafish LTJT and SSC formation. In addition, the elevation of TSH levels appears to be essential for goiter appearance in zebrafish." @default.
• W3193161436 created "2021-08-16" @default.
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• W3193161436 date "2021-08-04" @default.
• W3193161436 modified "2023-10-09" @default.
• W3193161436 title "Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models" @default.
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• W3193161436 cites W1970177972 @default.
• W3193161436 cites W1975345061 @default.
• W3193161436 cites W1977316704 @default.
• W3193161436 cites W1977391294 @default.
• W3193161436 cites W1978529094 @default.
• W3193161436 cites W1979287356 @default.
• W3193161436 cites W1992268803 @default.
• W3193161436 cites W1997168010 @default.
• W3193161436 cites W1999728382 @default.
• W3193161436 cites W1999753634 @default.
• W3193161436 cites W2003171404 @default.
• W3193161436 cites W2003889007 @default.
• W3193161436 cites W2004471830 @default.
• W3193161436 cites W2009663577 @default.
• W3193161436 cites W2014966769 @default.
• W3193161436 cites W2023982069 @default.
• W3193161436 cites W2025894647 @default.
• W3193161436 cites W2031953721 @default.
• W3193161436 cites W2034312179 @default.
• W3193161436 cites W2035089406 @default.
• W3193161436 cites W2038487944 @default.
• W3193161436 cites W2038915039 @default.
• W3193161436 cites W2068607454 @default.
• W3193161436 cites W2073425230 @default.
• W3193161436 cites W2080874791 @default.
• W3193161436 cites W2082167836 @default.
• W3193161436 cites W2096936451 @default.
• W3193161436 cites W2102611661 @default.
• W3193161436 cites W2123017497 @default.
• W3193161436 cites W2141625966 @default.
• W3193161436 cites W2142908518 @default.
• W3193161436 cites W2148607599 @default.
• W3193161436 cites W2149476005 @default.
• W3193161436 cites W2152327803 @default.
• W3193161436 cites W2168245648 @default.
• W3193161436 cites W2168919757 @default.
• W3193161436 cites W2173065406 @default.
• W3193161436 cites W2192088777 @default.
• W3193161436 cites W2224668128 @default.
• W3193161436 cites W2262699654 @default.
• W3193161436 cites W2267420973 @default.
• W3193161436 cites W2331305139 @default.
• W3193161436 cites W2344918469 @default.
• W3193161436 cites W2443984374 @default.
• W3193161436 cites W2497063391 @default.
• W3193161436 cites W2513683667 @default.
• W3193161436 cites W2567054134 @default.
• W3193161436 cites W2615794959 @default.
• W3193161436 cites W2760922169 @default.
• W3193161436 cites W2769983444 @default.
• W3193161436 cites W2780245857 @default.
• W3193161436 cites W2794227565 @default.
• W3193161436 cites W2794346468 @default.
• W3193161436 cites W2794606992 @default.
• W3193161436 cites W2802770335 @default.
• W3193161436 cites W2808948286 @default.
• W3193161436 cites W2889621124 @default.
• W3193161436 cites W2889674915 @default.
• W3193161436 cites W2917900659 @default.
• W3193161436 cites W2949681989 @default.
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• W3193161436 doi "https://doi.org/10.3390/cells10081984" @default.
• W3193161436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8391828" @default.
• W3193161436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34440752" @default.
• W3193161436 hasPublicationYear "2021" @default.
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