Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193334787> ?p ?o ?g. }
- W3193334787 endingPage "1946" @default.
- W3193334787 startingPage "1935" @default.
- W3193334787 abstract "The fields of precision imaging and drug delivery have revealed a number of tools to improve target specificity and increase efficacy in diagnosing and treating disease. Biological molecules, such as antibodies, continue to be the primary means of assuring active targeting of various payloads. However, molecular-scale recognition motifs have emerged in recent decades to achieve specificity through the design of interacting chemical motifs. In this regard, an assortment of bioorthogonal covalent conjugations offer possibilities for in situ complexation under physiological conditions. Herein, a related concept is discussed that leverages interactions from noncovalent or supramolecular motifs to facilitate in situ recognition and complex formation in the body. Classic supramolecular motifs based on host-guest complexation offer one such means of facilitating recognition. In addition, synthetic bioinspired motifs based on oligonucleotide hybridization and coiled-coil peptide bundles afford other routes to form complexes in situ. The architectures to include recognition of these various motifs for targeting enable both monovalent and multivalent presentation, seeking high affinity or engineered avidity to facilitate conjugation even under dilute conditions of the body. Accordingly, supramolecular click chemistry offers a complementary tool in the growing arsenal targeting improved healthcare efficacy." @default.
- W3193334787 created "2021-08-30" @default.
- W3193334787 creator A5016534758 @default.
- W3193334787 creator A5034545287 @default.
- W3193334787 creator A5086093895 @default.
- W3193334787 date "2021-08-20" @default.
- W3193334787 modified "2023-09-26" @default.
- W3193334787 title "Supramolecular “Click Chemistry” for Targeting in the Body" @default.
- W3193334787 cites W1087259 @default.
- W3193334787 cites W1560197628 @default.
- W3193334787 cites W1564028741 @default.
- W3193334787 cites W1598189694 @default.
- W3193334787 cites W1781421830 @default.
- W3193334787 cites W1964146045 @default.
- W3193334787 cites W1964674096 @default.
- W3193334787 cites W1968971176 @default.
- W3193334787 cites W1973528774 @default.
- W3193334787 cites W1978407833 @default.
- W3193334787 cites W1980301976 @default.
- W3193334787 cites W1987346828 @default.
- W3193334787 cites W1988901523 @default.
- W3193334787 cites W1989230986 @default.
- W3193334787 cites W1989368359 @default.
- W3193334787 cites W1995487009 @default.
- W3193334787 cites W1996275708 @default.
- W3193334787 cites W1996940505 @default.
- W3193334787 cites W1997099073 @default.
- W3193334787 cites W2003845311 @default.
- W3193334787 cites W2008235836 @default.
- W3193334787 cites W2008348255 @default.
- W3193334787 cites W2009071379 @default.
- W3193334787 cites W2010120270 @default.
- W3193334787 cites W2014583580 @default.
- W3193334787 cites W2016162029 @default.
- W3193334787 cites W2016384435 @default.
- W3193334787 cites W2017956110 @default.
- W3193334787 cites W2019274418 @default.
- W3193334787 cites W2019818589 @default.
- W3193334787 cites W2022179907 @default.
- W3193334787 cites W2026710381 @default.
- W3193334787 cites W2028259367 @default.
- W3193334787 cites W2029445411 @default.
- W3193334787 cites W2031281559 @default.
- W3193334787 cites W2032404673 @default.
- W3193334787 cites W2034609970 @default.
- W3193334787 cites W2038573488 @default.
- W3193334787 cites W2043672286 @default.
- W3193334787 cites W2055706807 @default.
- W3193334787 cites W2056747336 @default.
- W3193334787 cites W2059183805 @default.
- W3193334787 cites W2065315696 @default.
- W3193334787 cites W2066074720 @default.
- W3193334787 cites W2066580507 @default.
- W3193334787 cites W2071230707 @default.
- W3193334787 cites W2073184464 @default.
- W3193334787 cites W2073948759 @default.
- W3193334787 cites W2077534391 @default.
- W3193334787 cites W2079928202 @default.
- W3193334787 cites W2081484463 @default.
- W3193334787 cites W2088374507 @default.
- W3193334787 cites W2088396668 @default.
- W3193334787 cites W2091229935 @default.
- W3193334787 cites W2098742973 @default.
- W3193334787 cites W2111789849 @default.
- W3193334787 cites W2112333437 @default.
- W3193334787 cites W2119927970 @default.
- W3193334787 cites W2120796071 @default.
- W3193334787 cites W2122480363 @default.
- W3193334787 cites W2125814580 @default.
- W3193334787 cites W2132145242 @default.
- W3193334787 cites W2135883962 @default.
- W3193334787 cites W2135995702 @default.
- W3193334787 cites W2139902274 @default.
- W3193334787 cites W2140893204 @default.
- W3193334787 cites W2148306017 @default.
- W3193334787 cites W2158300218 @default.
- W3193334787 cites W2165499430 @default.
- W3193334787 cites W2166802510 @default.
- W3193334787 cites W2174246843 @default.
- W3193334787 cites W2192072986 @default.
- W3193334787 cites W2223513414 @default.
- W3193334787 cites W2226713972 @default.
- W3193334787 cites W2300671107 @default.
- W3193334787 cites W2313407792 @default.
- W3193334787 cites W2313714086 @default.
- W3193334787 cites W2318151286 @default.
- W3193334787 cites W2319215497 @default.
- W3193334787 cites W2334245206 @default.
- W3193334787 cites W2336977304 @default.
- W3193334787 cites W2462731895 @default.
- W3193334787 cites W2513438212 @default.
- W3193334787 cites W2586475887 @default.
- W3193334787 cites W2588987678 @default.
- W3193334787 cites W2590862570 @default.
- W3193334787 cites W2592524531 @default.
- W3193334787 cites W2597045666 @default.
- W3193334787 cites W2610592973 @default.
- W3193334787 cites W2735847121 @default.