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- W3193389872 abstract "The current study was conducted to investigate the nephroprotective effects of vildagliptin-metformin combination in an experimental model of fructose/salt-induced metabolic syndrome (MetS). A major aim was to evaluate the potential capacity of vitamin D3 to potentiate the pleiotropic nephroprotective effects of vildagliptin-metformin combination. MetS was induced in adult male Wistar rats by adding fructose (10%) to everyday drinking water and salt (3%) to the diet for 6 weeks. Along with the same concentrations of fructose/salt feeding, MetS rats were then treated orally with either vildagliptin (10 mg/kg/day)-metformin (200 mg/kg/day) combination, vitamin D3 (10 μg/kg/day), or the triple therapy for a further 6 weeks. The incidence of MetS was confirmed 6 weeks after fructose/salt consumption, when the rats exhibited significant weight gain, dyslipidemia, hyperuricemia, insulin resistance, hyperinsulinemia, and impaired glucose tolerance. At the end of the 12-week experimental period, MetS rats displayed significantly deteriorated renal function, enhanced intrarenal oxidative stress and inflammation together with exaggerated renal histopathological damages and interstitial fibrosis. The study has corroborated antioxidant, anti-inflammatory, and antifibrotic effects of vildagliptin-metformin combination, vitamin D3, and the triple collaborative therapy, conferring renoprotection in the setting of MetS. Due attention has been paid to the crucial role of dipeptidyl peptidase-4 inhibition and sirtuin-1/5' adenosine monophosphate-activated protein kinase activation as novel therapeutic targets to optimize renoprotection. The apparent potentiating effect, evoked upon coadministration of vitamin D3 with vildagliptin-metformin combination, may provide a cornerstone for further clinical investigations." @default.
- W3193389872 created "2021-08-30" @default.
- W3193389872 creator A5006452998 @default.
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- W3193389872 creator A5086528839 @default.
- W3193389872 date "2021-09-10" @default.
- W3193389872 modified "2023-09-26" @default.
- W3193389872 title "Vitamin D3 potentiates the nephroprotective effects of vildagliptin–metformin combination in a rat model of metabolic syndrome" @default.
- W3193389872 cites W1577133544 @default.
- W3193389872 cites W171699507 @default.
- W3193389872 cites W1764370285 @default.
- W3193389872 cites W1895532472 @default.
- W3193389872 cites W191793640 @default.
- W3193389872 cites W1950794459 @default.
- W3193389872 cites W1968338201 @default.
- W3193389872 cites W1973931485 @default.
- W3193389872 cites W1980542879 @default.
- W3193389872 cites W1981230812 @default.
- W3193389872 cites W1983310681 @default.
- W3193389872 cites W1985227122 @default.
- W3193389872 cites W2004426288 @default.
- W3193389872 cites W2011778618 @default.
- W3193389872 cites W2014880757 @default.
- W3193389872 cites W2025432773 @default.
- W3193389872 cites W2026620093 @default.
- W3193389872 cites W2033807650 @default.
- W3193389872 cites W2038083315 @default.
- W3193389872 cites W2039966938 @default.
- W3193389872 cites W2041905961 @default.
- W3193389872 cites W2047353065 @default.
- W3193389872 cites W2048487111 @default.
- W3193389872 cites W2049258403 @default.
- W3193389872 cites W2051142023 @default.
- W3193389872 cites W2054122582 @default.
- W3193389872 cites W2061059566 @default.
- W3193389872 cites W2061942966 @default.
- W3193389872 cites W2082639566 @default.
- W3193389872 cites W2088489118 @default.
- W3193389872 cites W2097140177 @default.
- W3193389872 cites W2108576543 @default.
- W3193389872 cites W2109612542 @default.
- W3193389872 cites W2116404316 @default.
- W3193389872 cites W2117228173 @default.
- W3193389872 cites W2119957365 @default.
- W3193389872 cites W2124624343 @default.
- W3193389872 cites W2124725201 @default.
- W3193389872 cites W2131383760 @default.
- W3193389872 cites W2133396367 @default.
- W3193389872 cites W2138304895 @default.
- W3193389872 cites W2139999609 @default.
- W3193389872 cites W2140406095 @default.
- W3193389872 cites W2140699761 @default.
- W3193389872 cites W2141485678 @default.
- W3193389872 cites W2143181482 @default.
- W3193389872 cites W2146693059 @default.
- W3193389872 cites W2147934894 @default.
- W3193389872 cites W2149341824 @default.
- W3193389872 cites W2151948477 @default.
- W3193389872 cites W2154774609 @default.
- W3193389872 cites W2160234571 @default.
- W3193389872 cites W2160382989 @default.
- W3193389872 cites W2161392734 @default.
- W3193389872 cites W2163918978 @default.
- W3193389872 cites W2165398964 @default.
- W3193389872 cites W2166051277 @default.
- W3193389872 cites W2259015036 @default.
- W3193389872 cites W2265603437 @default.
- W3193389872 cites W2286282461 @default.
- W3193389872 cites W2343961997 @default.
- W3193389872 cites W2388453346 @default.
- W3193389872 cites W2400466055 @default.
- W3193389872 cites W2407030308 @default.
- W3193389872 cites W2473182806 @default.
- W3193389872 cites W2507807596 @default.
- W3193389872 cites W2519364922 @default.
- W3193389872 cites W2523852855 @default.
- W3193389872 cites W2525729089 @default.
- W3193389872 cites W2547943265 @default.
- W3193389872 cites W2559772154 @default.
- W3193389872 cites W2559913810 @default.
- W3193389872 cites W2567916169 @default.
- W3193389872 cites W2570140084 @default.
- W3193389872 cites W2605287971 @default.
- W3193389872 cites W2605479507 @default.
- W3193389872 cites W2614302719 @default.
- W3193389872 cites W2751789497 @default.
- W3193389872 cites W2763671940 @default.
- W3193389872 cites W2769588514 @default.
- W3193389872 cites W2775755882 @default.
- W3193389872 cites W2780163861 @default.
- W3193389872 cites W2789430237 @default.
- W3193389872 cites W2794129387 @default.
- W3193389872 cites W2800110090 @default.
- W3193389872 cites W2804178984 @default.
- W3193389872 cites W2807468132 @default.