FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193405805> ?p ?o ?g. }

• W3193405805 abstract "Recent experimental observations have shown evidence of an unexpected sudden drop-off in the dense core vesicles (DCVs) content at the ends of certain types of axon endings. This article seeks to determine whether these observations may be explained without modifying the parameters characterizing the ability of distal en passant boutons to capture and accumulate DCVs. We developed a mathematical model that is based on the conservation of captured and transiting DCVs in boutons. The model consists of 77 ordinary differential equations and is solved using a standard Matlab solver. We hypothesize that the drop in DCV content in distal boutons is due to an insufficient supply of anterogradely moving DCVs coming from the soma. As anterogradely moving DCVs are captured (and eventually destroyed) in more proximal boutons on their way to the end of the terminal, the fluxes of anterogradely moving DCVs between the boutons become increasingly smaller, and the most distal boutons are left without DCVs. We tested this hypothesis by modifying the flux of DCVs entering the terminal and found that the number of most distal boutons left unfilled increases if the DCV flux entering the terminal is decreased. The number of anterogradely moving DCVs in the axon can be increased either by the release of a portion of captured DCVs into the anterograde component or by an increase of the anterograde DCV flux into the terminal. This increase could lead to having enough anterogradely moving DCVs such that they could reach the most distal bouton and then turn around by changing molecular motors that propel them. The model suggests that this could result in an increased concentration of resident DCVs in distal boutons beginning with bouton 2 (the most distal is bouton 1). This is because in distal boutons, DCVs have a larger chance to be captured from the transiting state as they pass the boutons moving anterogradely and then again as they pass the same boutons moving retrogradely." @default.
• W3193405805 created "2021-08-30" @default.
• W3193405805 creator A5008465009 @default.
• W3193405805 creator A5075453637 @default.
• W3193405805 date "2021-09-08" @default.
• W3193405805 modified "2023-09-25" @default.
• W3193405805 title "Simulation of a sudden drop‐off in distal dense core vesicle concentration in <i>Drosophila</i> type <scp>II</scp> motoneuron terminals" @default.
• W3193405805 cites W1196320696 @default.
• W3193405805 cites W1503543307 @default.
• W3193405805 cites W1554750796 @default.
• W3193405805 cites W1794036192 @default.
• W3193405805 cites W1967601924 @default.
• W3193405805 cites W1987312157 @default.
• W3193405805 cites W1995087873 @default.
• W3193405805 cites W2006994573 @default.
• W3193405805 cites W2016188701 @default.
• W3193405805 cites W2024843325 @default.
• W3193405805 cites W2029590370 @default.
• W3193405805 cites W2035441746 @default.
• W3193405805 cites W2046411113 @default.
• W3193405805 cites W2057198546 @default.
• W3193405805 cites W2070546151 @default.
• W3193405805 cites W2087225287 @default.
• W3193405805 cites W2094014274 @default.
• W3193405805 cites W2126118258 @default.
• W3193405805 cites W2149762749 @default.
• W3193405805 cites W2755959669 @default.
• W3193405805 cites W2766394001 @default.
• W3193405805 cites W2806480986 @default.
• W3193405805 cites W2888517237 @default.
• W3193405805 cites W2897675393 @default.
• W3193405805 cites W2902193623 @default.
• W3193405805 cites W2906364525 @default.
• W3193405805 cites W2952702685 @default.
• W3193405805 cites W2953014442 @default.
• W3193405805 cites W2970915438 @default.
• W3193405805 cites W3090655078 @default.
• W3193405805 doi "https://doi.org/10.1002/cnm.3523" @default.
• W3193405805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34418891" @default.
• W3193405805 hasPublicationYear "2021" @default.
• W3193405805 type Work @default.
• W3193405805 sameAs 3193405805 @default.
• W3193405805 citedByCount "0" @default.
• W3193405805 crossrefType "journal-article" @default.
• W3193405805 hasAuthorship W3193405805A5008465009 @default.
• W3193405805 hasAuthorship W3193405805A5075453637 @default.
• W3193405805 hasBestOaLocation W31934058052 @default.
• W3193405805 hasConcept C105702510 @default.
• W3193405805 hasConcept C121332964 @default.
• W3193405805 hasConcept C12554922 @default.
• W3193405805 hasConcept C169760540 @default.
• W3193405805 hasConcept C185592680 @default.
• W3193405805 hasConcept C2779530196 @default.
• W3193405805 hasConcept C2779617337 @default.
• W3193405805 hasConcept C2779664074 @default.
• W3193405805 hasConcept C41008148 @default.
• W3193405805 hasConcept C57879066 @default.
• W3193405805 hasConcept C76155785 @default.
• W3193405805 hasConcept C86803240 @default.
• W3193405805 hasConceptScore W3193405805C105702510 @default.
• W3193405805 hasConceptScore W3193405805C121332964 @default.
• W3193405805 hasConceptScore W3193405805C12554922 @default.
• W3193405805 hasConceptScore W3193405805C169760540 @default.
• W3193405805 hasConceptScore W3193405805C185592680 @default.
• W3193405805 hasConceptScore W3193405805C2779530196 @default.
• W3193405805 hasConceptScore W3193405805C2779617337 @default.
• W3193405805 hasConceptScore W3193405805C2779664074 @default.
• W3193405805 hasConceptScore W3193405805C41008148 @default.
• W3193405805 hasConceptScore W3193405805C57879066 @default.
• W3193405805 hasConceptScore W3193405805C76155785 @default.
• W3193405805 hasConceptScore W3193405805C86803240 @default.
• W3193405805 hasFunder F4320306076 @default.
• W3193405805 hasFunder F4320337346 @default.
• W3193405805 hasIssue "12" @default.
• W3193405805 hasLocation W31934058051 @default.
• W3193405805 hasLocation W31934058052 @default.
• W3193405805 hasLocation W31934058053 @default.
• W3193405805 hasOpenAccess W3193405805 @default.
• W3193405805 hasPrimaryLocation W31934058051 @default.
• W3193405805 hasRelatedWork W1967987001 @default.
• W3193405805 hasRelatedWork W1998119819 @default.
• W3193405805 hasRelatedWork W2000060717 @default.
• W3193405805 hasRelatedWork W2059256607 @default.
• W3193405805 hasRelatedWork W2069561992 @default.
• W3193405805 hasRelatedWork W2093052822 @default.
• W3193405805 hasRelatedWork W2101952786 @default.
• W3193405805 hasRelatedWork W2127637679 @default.
• W3193405805 hasRelatedWork W2142970695 @default.
• W3193405805 hasRelatedWork W2346960332 @default.
• W3193405805 hasVolume "37" @default.
• W3193405805 isParatext "false" @default.
• W3193405805 isRetracted "false" @default.
• W3193405805 magId "3193405805" @default.
• W3193405805 workType "article" @default.