Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193442875> ?p ?o ?g. }
- W3193442875 abstract "Abstract Brown adipose tissue (BAT) plays an important role on no shivering thermogenesis during cold exposure to maintain animal body temperature and energy homeostasis. However, knowledge of the cellular transition from white adipose tissue (WAT) to BAT is still limited. In this study, we provided a comprehensive metabolomics and transcriptional signatures of goat BAT and WAT. A total of 157 metabolites were significantly changed, including 81 upregulated and 76 downregulated metabolites. In addition, we identified the citric acid cycle, fatty acid elongation, and degradation pathways as coordinately activated in BAT. Interestingly, five unsaturated fatty acids (Eicosadienoic Acid, C20:2; γ‐Linolenic acid, C20:3; Arachidonic Acid, C20:4; Adrenic acid, C22:4; Docosahexaenoic acid, C22:6), Succinate, L‐carnitine, and L‐palmitoyl‐carnitine were found to be abundant in BAT. Furthermore, L‐carnitine, an intermediate of fatty acid degradation, is required for goat brown adipocyte differentiation and thermogenesis through activating AMPK pathway. However, L‐carnitine decreased lipid accumulation through inducing lipolysis and thermogenesis in white adipocytes. These results revealed that there are the significant alterations in transcriptomic and metabolomic profiles between goat WAT and BAT, which may contribute to better understanding the roles of metabolites in BAT thermogenesis process." @default.
- W3193442875 created "2021-08-30" @default.
- W3193442875 creator A5003642180 @default.
- W3193442875 creator A5019160686 @default.
- W3193442875 creator A5027475930 @default.
- W3193442875 creator A5057310646 @default.
- W3193442875 creator A5064203710 @default.
- W3193442875 creator A5067545412 @default.
- W3193442875 creator A5070438189 @default.
- W3193442875 creator A5079490972 @default.
- W3193442875 creator A5079640236 @default.
- W3193442875 creator A5082400966 @default.
- W3193442875 creator A5087167893 @default.
- W3193442875 date "2021-08-27" @default.
- W3193442875 modified "2023-10-17" @default.
- W3193442875 title "Integrated application of metabolomics and RNA‐seq reveals thermogenic regulation in goat brown adipose tissues" @default.
- W3193442875 cites W143096088 @default.
- W3193442875 cites W1503760388 @default.
- W3193442875 cites W1537124032 @default.
- W3193442875 cites W1546743612 @default.
- W3193442875 cites W1968963111 @default.
- W3193442875 cites W1981525131 @default.
- W3193442875 cites W1983558349 @default.
- W3193442875 cites W1988869711 @default.
- W3193442875 cites W1992326632 @default.
- W3193442875 cites W1999370292 @default.
- W3193442875 cites W2012216316 @default.
- W3193442875 cites W2027753197 @default.
- W3193442875 cites W2030070795 @default.
- W3193442875 cites W2034404865 @default.
- W3193442875 cites W2063287758 @default.
- W3193442875 cites W2083937450 @default.
- W3193442875 cites W2085567056 @default.
- W3193442875 cites W2086426509 @default.
- W3193442875 cites W2091553799 @default.
- W3193442875 cites W2102278945 @default.
- W3193442875 cites W2104005232 @default.
- W3193442875 cites W2117031630 @default.
- W3193442875 cites W2126272143 @default.
- W3193442875 cites W2148720130 @default.
- W3193442875 cites W2152239989 @default.
- W3193442875 cites W2153856742 @default.
- W3193442875 cites W2160787227 @default.
- W3193442875 cites W2176909443 @default.
- W3193442875 cites W2269590188 @default.
- W3193442875 cites W2290337523 @default.
- W3193442875 cites W2301389244 @default.
- W3193442875 cites W2519117803 @default.
- W3193442875 cites W2611486163 @default.
- W3193442875 cites W2696298149 @default.
- W3193442875 cites W2766393670 @default.
- W3193442875 cites W2766504728 @default.
- W3193442875 cites W2767714100 @default.
- W3193442875 cites W2784374391 @default.
- W3193442875 cites W2788724769 @default.
- W3193442875 cites W2788772427 @default.
- W3193442875 cites W2790580419 @default.
- W3193442875 cites W2791215968 @default.
- W3193442875 cites W2794345887 @default.
- W3193442875 cites W2801767676 @default.
- W3193442875 cites W2803317673 @default.
- W3193442875 cites W2803960767 @default.
- W3193442875 cites W2885192168 @default.
- W3193442875 cites W2888520528 @default.
- W3193442875 cites W2903107073 @default.
- W3193442875 cites W2965642281 @default.
- W3193442875 cites W2967178138 @default.
- W3193442875 cites W2967563340 @default.
- W3193442875 cites W2973933417 @default.
- W3193442875 cites W2991649109 @default.
- W3193442875 cites W2998107369 @default.
- W3193442875 cites W3018231282 @default.
- W3193442875 cites W3045219339 @default.
- W3193442875 cites W3084095015 @default.
- W3193442875 cites W3103538859 @default.
- W3193442875 cites W3138370393 @default.
- W3193442875 cites W3145059895 @default.
- W3193442875 cites W3174077572 @default.
- W3193442875 cites W405180396 @default.
- W3193442875 doi "https://doi.org/10.1096/fj.202100493rr" @default.
- W3193442875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34449920" @default.
- W3193442875 hasPublicationYear "2021" @default.
- W3193442875 type Work @default.
- W3193442875 sameAs 3193442875 @default.
- W3193442875 citedByCount "8" @default.
- W3193442875 countsByYear W31934428752022 @default.
- W3193442875 countsByYear W31934428752023 @default.
- W3193442875 crossrefType "journal-article" @default.
- W3193442875 hasAuthorship W3193442875A5003642180 @default.
- W3193442875 hasAuthorship W3193442875A5019160686 @default.
- W3193442875 hasAuthorship W3193442875A5027475930 @default.
- W3193442875 hasAuthorship W3193442875A5057310646 @default.
- W3193442875 hasAuthorship W3193442875A5064203710 @default.
- W3193442875 hasAuthorship W3193442875A5067545412 @default.
- W3193442875 hasAuthorship W3193442875A5070438189 @default.
- W3193442875 hasAuthorship W3193442875A5079490972 @default.
- W3193442875 hasAuthorship W3193442875A5079640236 @default.
- W3193442875 hasAuthorship W3193442875A5082400966 @default.
- W3193442875 hasAuthorship W3193442875A5087167893 @default.
- W3193442875 hasConcept C126322002 @default.