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• W3193451709 abstract "BACKGROUND AND AIM: Wastewater surveillance has emerged during the COVID-19 pandemic as a unique tool that provides a pooled community sample of SARS-CoV-2 infection. This surveillance method is not dependent on access to testing or health care seeking behaviors. Through a multi-disciplinary collaboration between epidemiologists, laboratory scientists, water reclamation managers, and environmental engineers, this strategy has promising applications for large-scale pathogen, pharmaceutical, and chemical exposure monitoring. METHODS: In collaboration with University of North Carolina (UNC) system researchers, the North Carolina Department of Health and Human Services (NCDHHS) was one of eight state health departments initially funded by the Centers for Disease Control and Prevention (CDC) to participate in the National Wastewater Surveillance System (NWSS) in September 2020. In January 2021, NCDHHS began collecting twice weekly samples at eleven wastewater treatment plants (WWTPs) for digital droplet polymerase chain reaction (ddPCR) analysis at UNC as part of the North Carolina Wastewater Monitoring Network. NC was the first state to operationalize the CDC’s analytics pipeline, submitting wastewater data weekly along with geocoded COVID-19 cases from contributing sewersheds to see if wastewater trends are increasing, decreasing, or plateauing. During the summer of 2021, nine additional sites are being added to the network to increase geographic representation and coverage of populations with higher social vulnerability, with 15 additional sites planned for later in 2021. RESULTS:Peak wastewater levels were observed in January 2021 with gradual declines during spring 2021. Trends mirrored decreases in COVID-19 cases as vaccination efforts expanded and transmission slowed. By June 2021, most sites are in plateau status and several have had repeated nondetects. CONCLUSIONS:Success in measuring SARS-CoV-2 in wastewater is prompting interest in measuring other pathogens, pharmaceuticals, and chemical exposures at the population level. The NC Wastewater Monitoring Network has built a foundation of partnerships that will continue to expand capacity for wastewater-based epidemiology in NC. KEYWORDS: wastewater, surveillance, SARS-CoV-2, epidemiology, environment" @default.
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• W3193451709 date "2021-08-23" @default.
• W3193451709 modified "2023-09-26" @default.
• W3193451709 title "Wastewater Surveillance in North Carolina: Promoting Environmental Health Across Sectors" @default.
• W3193451709 doi "https://doi.org/10.1289/isee.2021.p-271" @default.
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