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• W3193523798 abstract "The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined. The different ways by which small molecules and their metabolites can elicit genotoxicity by DNA-reactive (direct) or non-DNA-reactive (indirect) mechanisms are discussed. Strategies to mitigate the most prevalent mechanisms of small molecule induced genotoxicity are provided and illustrated by examples." @default.
• W3193523798 created "2021-08-30" @default.
• W3193523798 creator A5010863061 @default.
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• W3193523798 date "2021-08-27" @default.
• W3193523798 modified "2023-09-24" @default.
• W3193523798 title "Genotoxicity" @default.
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• W3193523798 doi "https://doi.org/10.1039/9781788016414-00331" @default.
• W3193523798 hasPublicationYear "2021" @default.
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