Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193534018> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3193534018 endingPage "8" @default.
- W3193534018 startingPage "1" @default.
- W3193534018 abstract "Aims: The myocardial energy metabolism during Atrial Fibrillation (AF) a research hotspot. Proteomics provides a new method for the study of atrial fibrillation; however, there are no related studies of the effect of the Left Atrial Appendage (LAA) on the energy metabolism of the atrial muscle. We use proteomics to analyze the effect of resection of the LAA on the energy metabolism of the left atrial myocardial cells in beagle dogs with rapid atrial pacing.Methods: Nine beagle dogs were divided into three groups: the model group (rapid atrial pacing/LAA resection), the positive control group (rapid atrial pacing/LAA preservation), and the negative control group (sinus rhythm). Twelve weeks later, the atrial tissues were resected for proteomics study. Parallel Reaction Monitoring (PRM) was used for the validation of the targeted proteomics.Results: 55 proteins were up regulated and 68 proteins were down regulated in the experimental vs. the positive control group. Proteins related to glucose and lipid metabolism were mainly down regulated, and mitochondria- related proteins were mainly down regulated during rapid atrial pacing compared with sinus rhythm. After resection of the LAA, glucose-metabolism-related proteins showed a significant up regulation trend, lipid metabolism-related proteins were further down regulated, whereas mitochondria-related proteins were up regulated compared with rapid atrial pacing with LAA preservation. PRM confirmed the reliability of the proteomics results.Conclusion: In the setting of AF, the resection of the LAA had a relatively large effect on the energy metabolism structure by affecting the quantity and functions of mitochondria." @default.
- W3193534018 created "2021-08-30" @default.
- W3193534018 creator A5010851711 @default.
- W3193534018 creator A5026098740 @default.
- W3193534018 creator A5030887101 @default.
- W3193534018 creator A5040926327 @default.
- W3193534018 creator A5077079985 @default.
- W3193534018 creator A5078572397 @default.
- W3193534018 date "2021-08-10" @default.
- W3193534018 modified "2023-09-23" @default.
- W3193534018 title "Proteomics Study of the Effect Left Atrial Appendage Resection on theEnergy Metabolism of Atrial Muscle in Beagle Dogs with Rapid Atrial Pacing" @default.
- W3193534018 doi "https://doi.org/10.35248/2153-0602.21.s7.003" @default.
- W3193534018 hasPublicationYear "2021" @default.
- W3193534018 type Work @default.
- W3193534018 sameAs 3193534018 @default.
- W3193534018 citedByCount "0" @default.
- W3193534018 crossrefType "posted-content" @default.
- W3193534018 hasAuthorship W3193534018A5010851711 @default.
- W3193534018 hasAuthorship W3193534018A5026098740 @default.
- W3193534018 hasAuthorship W3193534018A5030887101 @default.
- W3193534018 hasAuthorship W3193534018A5040926327 @default.
- W3193534018 hasAuthorship W3193534018A5077079985 @default.
- W3193534018 hasAuthorship W3193534018A5078572397 @default.
- W3193534018 hasConcept C104317684 @default.
- W3193534018 hasConcept C126322002 @default.
- W3193534018 hasConcept C164705383 @default.
- W3193534018 hasConcept C2775914520 @default.
- W3193534018 hasConcept C2776820430 @default.
- W3193534018 hasConcept C2779161974 @default.
- W3193534018 hasConcept C2910272107 @default.
- W3193534018 hasConcept C46111723 @default.
- W3193534018 hasConcept C4733338 @default.
- W3193534018 hasConcept C55493867 @default.
- W3193534018 hasConcept C62231903 @default.
- W3193534018 hasConcept C71924100 @default.
- W3193534018 hasConcept C86803240 @default.
- W3193534018 hasConceptScore W3193534018C104317684 @default.
- W3193534018 hasConceptScore W3193534018C126322002 @default.
- W3193534018 hasConceptScore W3193534018C164705383 @default.
- W3193534018 hasConceptScore W3193534018C2775914520 @default.
- W3193534018 hasConceptScore W3193534018C2776820430 @default.
- W3193534018 hasConceptScore W3193534018C2779161974 @default.
- W3193534018 hasConceptScore W3193534018C2910272107 @default.
- W3193534018 hasConceptScore W3193534018C46111723 @default.
- W3193534018 hasConceptScore W3193534018C4733338 @default.
- W3193534018 hasConceptScore W3193534018C55493867 @default.
- W3193534018 hasConceptScore W3193534018C62231903 @default.
- W3193534018 hasConceptScore W3193534018C71924100 @default.
- W3193534018 hasConceptScore W3193534018C86803240 @default.
- W3193534018 hasLocation W31935340181 @default.
- W3193534018 hasOpenAccess W3193534018 @default.
- W3193534018 hasPrimaryLocation W31935340181 @default.
- W3193534018 hasRelatedWork W1969616261 @default.
- W3193534018 hasRelatedWork W2032497609 @default.
- W3193534018 hasRelatedWork W2066011118 @default.
- W3193534018 hasRelatedWork W2078507865 @default.
- W3193534018 hasRelatedWork W2094628252 @default.
- W3193534018 hasRelatedWork W2168441550 @default.
- W3193534018 hasRelatedWork W2230428091 @default.
- W3193534018 hasRelatedWork W2314420477 @default.
- W3193534018 hasRelatedWork W2349404909 @default.
- W3193534018 hasRelatedWork W2349519216 @default.
- W3193534018 hasRelatedWork W2353702368 @default.
- W3193534018 hasRelatedWork W2354871753 @default.
- W3193534018 hasRelatedWork W2362487492 @default.
- W3193534018 hasRelatedWork W2379024379 @default.
- W3193534018 hasRelatedWork W2405560221 @default.
- W3193534018 hasRelatedWork W2804256970 @default.
- W3193534018 hasRelatedWork W2889828764 @default.
- W3193534018 hasRelatedWork W3108028249 @default.
- W3193534018 hasRelatedWork W3187028020 @default.
- W3193534018 hasRelatedWork W3204661540 @default.
- W3193534018 isParatext "false" @default.
- W3193534018 isRetracted "false" @default.
- W3193534018 magId "3193534018" @default.
- W3193534018 workType "article" @default.