FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193542764> ?p ?o ?g. }

• W3193542764 abstract "Abstract Background Several previous studies have implied the significance of lncRNA1410 (LINC01410) in gastric cancer, rectal cancer, and cervical cancer. Nevertheless, the potential of LINC01410 in bladder cancer (BC) development has not been addressed. Methods The related mechanisms were explored by qRT-PCR analysis, CCK-8 assay, cell transfection assay, Transwell assay, Western Blot analysis, Luciferase reporter assay and RNA pull-down assay. Results In the following study, LINC01410, characterized as an oncogene, exhibited high levels of expression in BC tissues as compared to normal tissues and its expression leads to a reduced prognosis of BC. Functional characterization of LINC01410 showed that knocking down LINC01410 could markedly reduce the invasion and proliferation capacity of T24 and 5637 cells. Mechanistically, LINC01410 served as a sponge for miR-4319 and the findings were further attested through luciferase reporter assay. Analysis of miR-4319 demonstrated its low expression in BC tissues as compared to normal tissues and knocking down LINC01410 significantly increased miR-4319. Data obtained from rescue assay discovered that silencing of miR-4319 in T24 and 5637 cells restored the proliferation and invasion capacity of LINC01410. Conclusions Taken together, this study is the first report on the oncogenic potential of LINC01410 in BC development by upregulating Snail1 protein and downregulating miR-4319. Trial registration Retrospectively registered." @default.
• W3193542764 created "2021-08-30" @default.
• W3193542764 creator A5013210725 @default.
• W3193542764 creator A5037565121 @default.
• W3193542764 creator A5046189089 @default.
• W3193542764 creator A5058077086 @default.
• W3193542764 creator A5060027462 @default.
• W3193542764 date "2021-08-14" @default.
• W3193542764 modified "2023-10-03" @default.
• W3193542764 title "LINC01410 leads the migration, invasion and EMT of bladder cancer cells by modulating miR-4319 / Snail1" @default.
• W3193542764 cites W1997363805 @default.
• W3193542764 cites W2131136280 @default.
• W3193542764 cites W2297445915 @default.
• W3193542764 cites W2310344966 @default.
• W3193542764 cites W2341866517 @default.
• W3193542764 cites W2473162054 @default.
• W3193542764 cites W2537531590 @default.
• W3193542764 cites W2570537891 @default.
• W3193542764 cites W2585735115 @default.
• W3193542764 cites W2603752903 @default.
• W3193542764 cites W2739254607 @default.
• W3193542764 cites W2751933285 @default.
• W3193542764 cites W2752007410 @default.
• W3193542764 cites W2782224317 @default.
• W3193542764 cites W2791211838 @default.
• W3193542764 cites W2791491676 @default.
• W3193542764 cites W2884348998 @default.
• W3193542764 cites W2889293774 @default.
• W3193542764 cites W2898606030 @default.
• W3193542764 cites W2946802359 @default.
• W3193542764 cites W2946977700 @default.
• W3193542764 cites W2950468512 @default.
• W3193542764 cites W2981630269 @default.
• W3193542764 cites W2993480363 @default.
• W3193542764 cites W3000177142 @default.
• W3193542764 cites W3005185765 @default.
• W3193542764 cites W3016304423 @default.
• W3193542764 cites W3048201207 @default.
• W3193542764 cites W3088639127 @default.
• W3193542764 cites W3093856995 @default.
• W3193542764 cites W3100366568 @default.
• W3193542764 cites W3102493364 @default.
• W3193542764 cites W3115880421 @default.
• W3193542764 doi "https://doi.org/10.1186/s12935-021-02119-z" @default.
• W3193542764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8364693" @default.
• W3193542764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34391433" @default.
• W3193542764 hasPublicationYear "2021" @default.
• W3193542764 type Work @default.
• W3193542764 sameAs 3193542764 @default.
• W3193542764 citedByCount "2" @default.
• W3193542764 countsByYear W31935427642023 @default.
• W3193542764 crossrefType "journal-article" @default.
• W3193542764 hasAuthorship W3193542764A5013210725 @default.
• W3193542764 hasAuthorship W3193542764A5037565121 @default.
• W3193542764 hasAuthorship W3193542764A5046189089 @default.
• W3193542764 hasAuthorship W3193542764A5058077086 @default.
• W3193542764 hasAuthorship W3193542764A5060027462 @default.
• W3193542764 hasBestOaLocation W31935427641 @default.
• W3193542764 hasConcept C104317684 @default.
• W3193542764 hasConcept C119056186 @default.
• W3193542764 hasConcept C11957725 @default.
• W3193542764 hasConcept C121608353 @default.
• W3193542764 hasConcept C126322002 @default.
• W3193542764 hasConcept C153911025 @default.
• W3193542764 hasConcept C173396325 @default.
• W3193542764 hasConcept C185592680 @default.
• W3193542764 hasConcept C2776415932 @default.
• W3193542764 hasConcept C2780783641 @default.
• W3193542764 hasConcept C2781018059 @default.
• W3193542764 hasConcept C29537977 @default.
• W3193542764 hasConcept C502942594 @default.
• W3193542764 hasConcept C54009773 @default.
• W3193542764 hasConcept C54355233 @default.
• W3193542764 hasConcept C55493867 @default.
• W3193542764 hasConcept C62112901 @default.
• W3193542764 hasConcept C71924100 @default.
• W3193542764 hasConcept C81885089 @default.
• W3193542764 hasConcept C86803240 @default.
• W3193542764 hasConceptScore W3193542764C104317684 @default.
• W3193542764 hasConceptScore W3193542764C119056186 @default.
• W3193542764 hasConceptScore W3193542764C11957725 @default.
• W3193542764 hasConceptScore W3193542764C121608353 @default.
• W3193542764 hasConceptScore W3193542764C126322002 @default.
• W3193542764 hasConceptScore W3193542764C153911025 @default.
• W3193542764 hasConceptScore W3193542764C173396325 @default.
• W3193542764 hasConceptScore W3193542764C185592680 @default.
• W3193542764 hasConceptScore W3193542764C2776415932 @default.
• W3193542764 hasConceptScore W3193542764C2780783641 @default.
• W3193542764 hasConceptScore W3193542764C2781018059 @default.
• W3193542764 hasConceptScore W3193542764C29537977 @default.
• W3193542764 hasConceptScore W3193542764C502942594 @default.
• W3193542764 hasConceptScore W3193542764C54009773 @default.
• W3193542764 hasConceptScore W3193542764C54355233 @default.
• W3193542764 hasConceptScore W3193542764C55493867 @default.
• W3193542764 hasConceptScore W3193542764C62112901 @default.
• W3193542764 hasConceptScore W3193542764C71924100 @default.
• W3193542764 hasConceptScore W3193542764C81885089 @default.
• W3193542764 hasConceptScore W3193542764C86803240 @default.
• W3193542764 hasFunder F4320321001 @default.
• W3193542764 hasIssue "1" @default.

• next