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• W3193590591 abstract "The proximal tubule (PT) is highly vulnerable to acute injury, including ischemic insult and nephrotoxins, and chronic kidney injury. It has been established that PT injury is a primary cause of the development of chronic kidney disease, but the underlying molecular mechanism remains to be defined. Here, we tested whether PT cyclophilin D (CypD), a mitochondrial matrix protein, is a critical factor to cause kidney fibrosis progression. To define the role of CypD in kidney fibrosis, we used an established mouse model for kidney fibrosis: the unilateral ureteral obstruction (UUO) model in global and PT-specific CypD knockout (KO). Global CypD KO blunted kidney fibrosis progression with inhibition of myofibroblast activation and fibrosis. UUO-induced tubular atrophy was suppressed in kidneys of global CypD KO but not tubular dilation or apoptotic cell death. PT cell cycle arrest was highly increased in wild-type UUO kidneys but was markedly attenuated in global CypD KO UUO kidneys. The number of macrophages and neutrophils was less in UUO kidneys of global CypD KO than those of wild-type kidneys. Proinflammatory and profibrotic factors were all inhibited in global CypD KO. In line with those of global CypD KO, PT-specific CypD KO also blunted kidney fibrosis progression, along with less tubular atrophy, renal parenchymal loss, cell cycle arrest in PT, and inflammation, indicating a critical role for PT CypD in fibrogenesis. Collectively, our data demonstrate that CypD in the PT is a critical factor contributing to kidney fibrosis in UUO, providing a new paradigm for mitochondria-targeted therapeutics of fibrotic diseases.NEW & NOTEWORTHY It has been established that renal proximal tubule (PT) injury is a primary cause of the development of chronic kidney disease, but the underlying molecular mechanism remains to be defined. Here, we show that cyclophilin D, a mitochondrial matrix protein, in the PT causes kidney fibrogenesis in obstructive nephropathy. Our data suggest that targeting PT cyclophilin D could be beneficial to prevent fibrosis progression." @default.
• W3193590591 created "2021-08-30" @default.
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• W3193590591 date "2021-10-01" @default.
• W3193590591 modified "2023-10-17" @default.
• W3193590591 title "Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy" @default.
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• W3193590591 cites W1966536813 @default.
• W3193590591 cites W1970377223 @default.
• W3193590591 cites W1974159999 @default.
• W3193590591 cites W1977437151 @default.
• W3193590591 cites W1991436274 @default.
• W3193590591 cites W1991997670 @default.
• W3193590591 cites W2002439304 @default.
• W3193590591 cites W2009572885 @default.
• W3193590591 cites W2014758663 @default.
• W3193590591 cites W2021690806 @default.
• W3193590591 cites W2025914300 @default.
• W3193590591 cites W2040281422 @default.
• W3193590591 cites W2040371936 @default.
• W3193590591 cites W2042643919 @default.
• W3193590591 cites W2063099262 @default.
• W3193590591 cites W2065924458 @default.
• W3193590591 cites W2066562992 @default.
• W3193590591 cites W2068050227 @default.
• W3193590591 cites W2074800090 @default.
• W3193590591 cites W2079079821 @default.
• W3193590591 cites W2087429403 @default.
• W3193590591 cites W2087881362 @default.
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• W3193590591 cites W2100659636 @default.
• W3193590591 cites W2102094290 @default.
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• W3193590591 cites W2216095137 @default.
• W3193590591 cites W2220751146 @default.
• W3193590591 cites W2267116164 @default.
• W3193590591 cites W2333220158 @default.
• W3193590591 cites W2340940178 @default.
• W3193590591 cites W2399361349 @default.
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• W3193590591 doi "https://doi.org/10.1152/ajprenal.00171.2021" @default.
• W3193590591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8560409" @default.
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