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• W3193646722 abstract "Objective. Chaihu Jia Longgu Muli decoction (CLMD) is widely used in the treatment of poststroke depression (PSD) in China. Some evidences show that it has advantages, but there lacks reliable evidence. This study aims to systematically evaluate the efficacy and safety of CLMD in the treatment of PSD. Methods. All randomized controlled trials (RCTs) of CLMD in the treatment of PSD were searched from the following databases: PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Chinese Biomedical Literature Service System (CBM), from their inception to May 2021. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan5.3 software. Results. A total of 13 RCTs involving 1665 patients were finally included in this study, among which 5 RCTs were oral CLMD alone versus antidepressants, and 8 RCTs were oral CLMD with antidepressants versus antidepressants. Meta-analysis results showed that oral administration of CLMD could improve Hamilton’s Depression Scale (HAMD) and the Modified Edinburgh-Scandinavian Stroke Scale (MESSS) scores, improve the Barthel index, and have a low rate of adverse reactions, but there was no significant difference in the total effective rate ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>p</mi> <mo>=</mo> <mn>0.21</mn> </math> > 0.05) and the National Institute of Health Stroke Scale (NIHSS) score ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>p</mi> <mo>=</mo> <mn>0.47</mn> </math> > 0.05) between the antidepressants group and the oral administration of the CLMD group. Oral CLMD combined with antidepressants could improve the total effective rate, HAMD, and MESSS score, but there was no significant difference in Barthel index ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>p</mi> <mo>=</mo> <mn>0.06</mn> </math> > 0.05) and the adverse reaction rate ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>p</mi> <mo>=</mo> <mn>0.14</mn> </math> > 0.05) between the two groups. Conclusion. Current evidence suggests that oral CLMD alone or with antidepressants is more effective and safer in the treatment of PSD than oral antidepressants. Due to the limitation of the quality and quantity of the included studies, more high-quality studies are needed to confirm the above conclusion." @default.
• W3193646722 created "2021-08-30" @default.
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• W3193646722 date "2021-08-19" @default.
• W3193646722 modified "2023-10-16" @default.
• W3193646722 title "Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis" @default.
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• W3193646722 doi "https://doi.org/10.1155/2021/7604537" @default.
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