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• W3193646757 endingPage "108824" @default.
• W3193646757 startingPage "108824" @default.
• W3193646757 abstract "The current intersection of the COVID-19 and HIV-1 pandemics, has raised concerns about the risk for poor COVID-19 outcomes particularly in regions like sub-Saharan Africa, disproportionally affected by HIV. DPP4/CD26 has been suggested to be a potential therapeutic target and a biomarker for risk in COVID-19 patients with high risk co-morbidities. We therefore evaluated soluble DPP4 (sDPP4) levels and activity in plasma of 131 HIV-infected and 20 HIV-uninfected South African individuals. Flow cytometry was performed to compare cell surface expression of DPP4/CD26 and activation markers on peripheral blood mononuclear cells of extreme clinical phenotypes. Progressors had lower specific DPP4 activity and lower frequency of CD3+ T-cells expressing CD26 than HIV-1 controllers, but more activated CD3+CD26+ T-cells. The frequency of CD26-expressing T-cells negatively correlated with HLA-DR+ and CD38+ T-cells. Divergent DPP4/CD26 expression between HIV-1 controllers and progressors may have implications for risk and treatment of COVID-19 in people living with HIV." @default.
• W3193646757 created "2021-08-30" @default.
• W3193646757 creator A5010437298 @default.
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• W3193646757 date "2021-09-01" @default.
• W3193646757 modified "2023-10-17" @default.
• W3193646757 title "Systemic DPP4/CD26 is associated with natural HIV-1 control: Implications for COVID-19 susceptibility" @default.
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• W3193646757 doi "https://doi.org/10.1016/j.clim.2021.108824" @default.
• W3193646757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8360992" @default.
• W3193646757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34391936" @default.

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