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- W3193669702 abstract "<h3>Background</h3> Hemodialysis arteriovenous fistulas (AVFs) are the preferred vascular access for patients on hemodialysis. In the Hemodialysis Fistula Maturation Study, 44% of the patients achieved unassisted maturation of their fistula without needing an intervention. Venous neointimal hyperplasia (VNH) and subsequent venous stenosis are responsible for lack of maturation. There are no therapies that can prevent VNH/VS formation. The goal of this paper is to present the background, rationale, and trial design of an innovative phase 1/2 clinical study that is investigating the safety of autologous adipose-derived mesenchymal stem cells delivered locally to the adventitia of newly created upper extremity radiocephalic (RCF) or brachiocephalic fistula (BCF). <h3>Methods</h3> The rationale and preclinical studies used to obtain a physician-sponsored investigational new drug trial are discussed. The trial design and end points are discussed. <h3>Results</h3> This is an ongoing trial that will complete this year. <h3>Conclusion</h3> This is a phase 1/2 single-center, randomized trial that will investigate the safety and efficacy of autologous AMSCs in promoting maturation in new upper-extremity AVFs. <b>Clinical Trial registration number</b>: NCT02808208" @default.
- W3193669702 created "2021-08-30" @default.
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- W3193669702 date "2021-08-18" @default.
- W3193669702 modified "2023-10-03" @default.
- W3193669702 title "Functional disorders after COVID-19 vaccine fuel vaccination hesitancy" @default.
- W3193669702 cites W2805331168 @default.
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- W3193669702 doi "https://doi.org/10.1136/jnnp-2021-327000" @default.
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